[Role of adhesion molecules in a determination of progression stages and clinical prognosis of patients with Echinococcus multilocularis]
Alveococcosis in humans is characterized by a tumor-like growth with a tendency to infiltration of neighbouring organs or metastases formation in the lungs and brain. The study aimed to improve on the clinical evaluation of patients with alveolar echinococcosis (AE) and to determine the risk of metacestode spreading to adjacent tissues or distant organs by a detection of adhesion molecules involved in the tumorigenesis process. Serum concentrations of sPECAM-1, sVCAM-1 and sE-selectin adhesion molecules were studied in 8 AE patients in comparison to 75 cases with malignant neoplasms, including cases with tumors of hepatic and extra-hepatic location. The adhesion molecules were found to be early predictive markers of the active, tissue infiltrated alveococcosis with the risk of parasite spreading through the circulation. High serum levels of soluble PECAM-1 molecule were strongly related to the advanced, progressive disease and the fatality of patients' clinical prognosis.
- [Show abstract] [Hide abstract] ABSTRACT: Objective. Echinococcosis is a rather seldom detected parasitic disease affecting the CNS in 2% of cases only. Diagnostic difficulties occur if presentations in neuroimaging assessment are atypical, as in this disease serological tests can be negative for a long time since the onset of clinical symptoms. Cases. Two patients with echinococcosis are described: a 53-year-old man with an isolated cerebral form of echinococcosis and an atypical brain MRI scan showing disseminated focal lesions, and a woman aged 18, with an ophtalmic form of the disease and disseminated neurological signs. Commentary. Echinococcosis continues to be seen in Poland. Isolated intracerebral forms of this disease are very rare. The diagnosis should be based on neuroimaging findings, as well as serological test results and cerebrospinal fluid analysis. Oral treatment is an alternative method in non-operative cases.0Comments 0Citations
- [Show abstract] [Hide abstract] ABSTRACT: Background: Alveoccosis is one out of four plagues of the 21st century. In some cases diagnosis is very difficult. Case Raport: Patient JP, 52 yo male, wildlife handler was admitted to our hospital in 2006 because of disseminated disease of unknown etiology which was located in the retroperitoneal space, pericardium, liver, diaphragm, IVC, both lungs, pelvis and the stump of his right hip. In the past, he has been hospitalized in many orthopedic, surgical and tropical medicine departments because of the history of the stabbed wound of the right hip with phlegmon of the right thigh. Previously, a patient has been diagnosed to have TB which had been treated with the first-line drugs for a year with no clinical improvement. In 1999 he had undergone amputation of the right leg above the knee due to the osteitis and inability to drain a collection of a pus followed by lymphadenectomy of the inguinal nodes which revealed Histoplasmosis. The patient had been treated with ketokonazol for a year and which caused a 6 years remission of symptoms. In 2005, a progression of a disease had been observed and because of phlegmon in retroperitoneal space with a mass in right kidney and suprarenal gland the patient had right nephrectomy. In 2006 because of the progression of a disease, patient was admitted to our hospital. Patient underwent multiple operations including liver resection (seg. 8) venocavothomy, partial cystectomy of the pericardium followed by removal of the mass infiltrating the right psoas muscle and right pelvis. Immunological diagnosis by using a reference Western-blot technique has finally confirmed infection with Echinococcus multilocularis. Now, the patient is stabile and followed-up on a long-term chemotherapy with albendazol. Conclusions: Alveococcosis should be considered in differential diagnosis of every cystic mass in every anatomic location, especially when these occur in areas where the disease is endemic. Diagnosis and treatment requires multidisciplinary approach.0Comments 1Citation
- [Show abstract] [Hide abstract] ABSTRACT: Echinococcus multilocularis (EM) is caused by the larval stage of the tapeworm. The main endemic regions for human alveolar echinococcosis are Central Europe, Russia, Turkey, Japan, China, Eastern France, North America. EM is an endemic disease in Turkey and especially common in the eastern Anatolia Region as seen in our case. The liver is the primary focus of the disease, cerebral localization is rare. Cerebral hydatid disease is approximately 5% of alveolar hydatid cases and generally considered to be fatal. Surgical treatment should be considered whenever possible. We present a case of cerebral alveolar hydatid disease that was thought to be cerebral metastasis.0Comments 2Citations