Cognitive and motor development of 8-year-old children born after ICSI compared to spontaneously conceived children

Developmental and Lifespan Psychology, Centre for Medical Genetics, Vrije Universiteit Brussel, Brussels, Belgium.
Human Reproduction (Impact Factor: 4.57). 11/2006; 21(11):2922-9. DOI: 10.1093/humrep/del266
Source: PubMed


As a continuation of two large-scale, multicentre studies on the development of 5-year-old ICSI children, we present results of the follow-up study undertaken on the cognitive and motor development of 8-year-old ICSI children.
Developmental outcomes of 151 8-year-old singletons born through ICSI after 32 weeks of gestation were compared with those of 153 singletons of the same age born after spontaneous conception (SC). Part of this population was seen in a cohort at the age 5 years. Outcome measures include Wechsler Intelligence Scale for Children-Revised (WISC-R) and Movement Assessment Battery for Children (ABC).
Regarding intellectual functioning, ICSI children tend to obtain significantly higher total (P < 0.01), verbal (P < 0.01) and performance (P < 0.05) intelligence scores than SC children, nevertheless remaining in similar ranges. These effects are small (Cohen's d < 0.50). High maternal educational level stayed in the regression as a factor accounting for some of the variance in total IQ between the groups. In terms of motor development, no significant differences were found between ICSI and SC children regarding overall motor skills, manual, balance and ball skills.
In this follow-up study, ICSI and SC children show a comparable cognitive and motor development until the age of 8 years.

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Available from: Smadar Celestin-Westreich, Jan 14, 2015
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    • "In general, small short-term prospective analyses of the neurological development of children conceived from IVF and ICSI are reassuring, and indeed, one study suggested that children conceived as a result of IVF treatment may have a higher IQ than naturally conceived children (Leunens et al., 2006; Belva et al., 2007). However, a Belgium study (Leunens et al., 2006), after following their cohort for a further 2 years, commented that the IQ of the ICSI cohort approximated to the spontaneously conceived cohort, suggesting that this may represent an influence of maternal educational level on mental development in early life in the ICSI-conceived cohort (Leunens et al., 2008). A large US study demonstrated that IVF-conceived children perform better on standard testing than their matched peers for all grades "
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    ABSTRACT: BACKGROUND Limited data exist with regard to longer-term mental health and psychological functioning of children born from IVF treatment. With the known adverse perinatal outcome for children born from IVF treatment, it would be expected that there is a negative impact upon their mental development.METHODSA search strategy restricted to studies relating to the medical condition of children of at least 1 year of age, born from IVF treatment was performed to include case series, data linkage and prospective studies published from 1 January 2000 to 1 April 2012.RESULTSLimited long-term follow-up data suggest that there is an increase in the incidence of cerebral palsy and neurodevelopmental delay related to the confounders of prematurity and low birthweight. Previous reports of associations with autism and attention-deficit disorder are believed to be related to maternal and obstetric factors. There exists a potential increase in the prevalence of early adulthood clinical depression and binge drinking in the offspring of IVF, with the reassuring data of no changes with respect to cognitive development, school performance, social functioning and behaviour. Whether these potential associations are related to the IVF treatment, the adverse obstetric outcomes associated with IVF treatment, the genetic or subsequent environmental influences on the children is yet to be determined.CONCLUSIONS In general, the longer-term mental and emotional health outcome for children born from IVF treatment is reassuring, and is very similar to that of naturally conceived children; however, further studies are required to explore any association with depression, and its causality in more detail.
    Full-text · Article · Feb 2013 · Human Reproduction Update
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    • "Cognitive and motor development studies using various assessment scales have generally found no differences between ICSI , IVF and naturally conceived children ( Bonduelle et al . , 2003 ; Kristoffersen et al . , 2005 ; Leslie et al . , 2003 ; Leunens et al . , 2006 ; Place and Englert , 2003 ; Ponjaert - Ponjaert - Kristoffersen et al . , 2004 ; Sutcliffe et al . , 2001 ) . Lower scale scores were found for ICSI versus naturally conceived children in two studies ( Bowen et al . , 1998 ; Knoester et al . , 2008 ) . Other parameters are comparable between ICSI children and those in the general popul"
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    ABSTRACT: The Sixth Evian Annual Reproduction (EVAR) Workshop Group Meeting was held to evaluate the impact of IVF/intracytoplasmic sperm injection on the health of assisted-conception children. Epidemiologists, reproductive endocrinologists, embryologists and geneticists presented data from published literature and ongoing research on the incidence of genetic and epigenetic abnormalities and congenital malformations in assisted-conception versus naturally conceived children to reach a consensus on the reasons for potential differences in outcomes between these two groups. IVF-conceived children have lower birthweights and higher peripheral fat, blood pressure and fasting glucose concentrations than controls. Growth, development and cognitive function in assisted-conception children are similar to controls. The absolute risk of imprinting disorders after assisted reproduction is less than 1%. A direct link between assisted reproduction and health-related outcomes in assisted-conception children could not be established. Women undergoing assisted reproduction are often older, increasing the chances of obtaining abnormal gametes that may cause deviations in outcomes between assisted-conception and naturally conceived children. However, after taking into account these factors, it is not clear to what extent poorer outcomes are due to the assisted reproduction procedures themselves. Large-scale, multicentre, prospective epidemiological studies are needed to investigate this further and to confirm long-term health consequences in assisted-conception children.
    Full-text · Article · Jan 2013 · Reproductive biomedicine online
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    • "It is known that children born after ART have a higher risk of a number of adverse perinatal outcomes, such as preterm birth (Helmerhorst et al., 2004; Jackson et al., 2004; Hansen et al., 2005). However, most studies show no impairment in overall motor development among children born after ART compared with spontaneously conceived children (Bowen et al., 1998; Sutcliffe et al., 2001; Olivennes et al., 2002; Bonduelle et al., 2003; Leslie et al., 2003; Ponjaert-Kristoffersen et al., 2004; Ponjaert-Kristoffersen et al., 2005; Leunens et al., 2006; Knoester et al., 2007; Wagenaar et al., 2009), but young age of the children at the time of assessment and methodological problems in the studies warrant continuing follow-up. In addition, we have previously reported a slight delay in some early motor developmental milestones among children born after infertility treatment (Zhu et al., 2009). "
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    ABSTRACT: It has previously been reported that children born after infertility treatment had a slight delay in early motor milestones. In this study, we examined whether children of infertile couples with or without infertility treatment had a higher risk of developmental coordination disorder (DCD). We used data on parental infertility and DCD among 23 167 singletons from the Danish National Birth Cohort (1996-2002). Data on time to pregnancy (TTP) and infertility treatment were collected early in pregnancy. Data on DCD in children were collected using the Developmental Coordination Disorder Questionnaire, filled in by the mothers during follow-up when the children were 7 years old. We used the recommended cut-off for the age group to classify children. Compared with children born of fertile couples, children conceived after a waiting TTP of longer than 12 months had a slightly higher risk of DCD [odds ratio (OR) 1.35, 95% confidence interval (CI) 1.03-1.77], but the estimated OR was not significant in children born after infertility treatment (OR 1.19, 95% CI 0.86-1.66). None of the individual treatment procedures was significantly associated with a higher risk of DCD. Children of parents who had not planned their pregnancy showed no elevated risk. Our findings are overall reassuring, although it is possible that low fecundity may be associated with a modestly increased risk of DCD.
    Preview · Article · Feb 2010 · Human Reproduction
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