Immunohistochemical Distribution of Amyloid Deposits in 25 Cows Diagnosed with Systemic AA Amyloidosis

ArticleinJournal of Veterinary Medical Science 68(7):725-9 · August 2006with6 Reads
Impact Factor: 0.78 · DOI: 10.1292/jvms.68.725 · Source: PubMed


    The distribution of amyloid deposits was histopathologically and immunohistochemically examined in 25 cows aged 5 to 10 years that had been diagnosed with systemic AA amyloidosis. This examination revealed that amyloid deposits were also present in the hypophysis, ovary, uterus, mammary gland and skeletal muscle, in addition to the liver, kidney, spleen, pancreas, thyroid gland, adrenal gland, gastrointestinal mucosa, heart, lung and lymph nodes. The examined cows tended to have chronic inflammations, including chronic mastitis (six cases) or chronic pneumonia (four cases), which is thought of as a causative agent of AA amyloidosis. In contrast, five cases did not exhibit any chronic inflammation.