The Switch on the RAPper's Necklace…

Department of Molecular Genetics, University of Texas Southwestern, Dallas, Texas 75390, USA.
Molecular Cell (Impact Factor: 14.02). 09/2006; 23(4):451-5. DOI: 10.1016/j.molcel.2006.07.026
Source: PubMed


The biosynthesis and export of LDL receptor-related proteins rely on specialized chaperones in the endoplasmic reticulum. Two recent papers in Molecular Cell by Fisher et al. (2006) and Lee et al. (2006) reveal a novel mechanism by which one of these chaperones, the receptor-associated protein RAP, accomplishes this task.

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