Potassium Excretion in Healthy Japanese Women Was Increased by a Dietary Intervention Utilizing Home-Parcel Delivery of Okinawan Vegetables

Department of Environmental and Preventive Medicine, Faculty of Medicine, University of the Ryukyus, Nishihara-cho, Okinawa, Japan.
Hypertension Research (Impact Factor: 2.66). 06/2006; 29(6):389-96. DOI: 10.1291/hypres.29.389
Source: PubMed


Potassium, which is abundant in vegetables, is inversely related to blood pressure. Although the situation has changed somewhat in recent years, the Okinawan diet has generally included a large amount of vegetables, and until recently Okinawans had the lowest rates of mortality due to stroke and coronary heart disease in Japan. Based on the hypothesis that these low mortality rates are partly attributable to increased potassium intake resulting from the high vegetable consumption, this study examined whether increasing the consumption of typical yellow-green Okinawan vegetables increases potassium intake. The purpose of this investigation was to determine whether increased consumption of these vegetables should be one of the dietary modifications recommended in public health promotion programs for Okinawans. The study employed 56 healthy, normotensive, free-living Japanese women aged 18-38 years living in Okinawa. They were randomized to a dietary intervention group (n=27) or a control group (n=29). Members of the dietary intervention group received an average weight of 371.4 g/day of a combination of the following vegetables twice weekly through an express home parcel deliver service for a period of 14 days: Goya (Momordica charantia), green papaya (Carica papaya), Handama (Gynura bicolor), Karashina (Brassica juncea), Njana (Crepidiastrum lanceolatium), Fuchiba (Artemisia vulgaris) and Fudanso (Beta vulgaris); and they consumed an average of 144.9 g/day, resulting in a 20.5% increase in their urinary potassium excretion over the baseline (p=0.045). The members of the control group were asked to avoid these vegetables, and the change in potassium excretion in this group was not significant (p=0.595). Urinary sodium and magnesium excretions, systolic and diastolic blood pressures, folic acid, triglycerides and serum high density lipoprotein cholesterol, low density lipoprotein cholesterol and total cholesterols changed non-significantly in both groups. Also, post-intervention urinary potassium excretion correlated positively with vegetable consumption in both the dietary intervention (p<0.0001) and control (p=0.008) groups and with Okinawan vegetable intake in the dietary intervention group (p=0.0004).

Download full-text


Available from: Hidemi Todoriki, Mar 15, 2014
  • Source
    • "Follow-up cohorts of older Okinawans have also been established for longitudinal study of particular age-related phenotypes, such as cognitive aging (Dodge et al., 2010; Katsumata et al., 2012). Intervention studies of the traditional Okinawan diet are also underway to assess biological effects on phenotypes reflective of healthy aging (Mano, Ishida, Ohya, Todoriki, & Takishita, 2009; Tuekpe, Todoriki, Sasaki, Zheng, & Ariizumi, 2006). Finally, the OCS also partners with other studies of the oldest old in comparative work such as the 5-Coun- try Oldest Old Project (5-COOP), which aims to specify the level of mortality selection among centenarians in five low-mortality countries—Denmark, France, Japan, Switzerland, and Sweden—to study the existence of a potential trade-off between the level of mortality selection and the functional health status of the oldest old (Robine et al., 2010), and the International Centenarian Consortium (n.d.), a collaboration with the Georgia Centenarian Study and other centenarian studies from around the world ( "
    [Show abstract] [Hide abstract]
    ABSTRACT: In the second section, five chapters expose and clarify the known and hypoth-esized factors favoring healthy longevity, starting with genetic and environ-mental factors and comparing and contrasting populations in Okinawa and Hawaii (Chapter 7). Chapter 8 then underlines the importance of mobility in human aging, whereas Chapter 9 describes the physical and biological indi-cators of health for the oldest old in the United States. The final chapters in this section focus on genetics with an example of gene–gene interaction using Chinese data (Chapter 10) and an introduction to gene expression and longevity (Chapter 11).
    Full-text · Chapter · Nov 2013
  • Source
    • "A few clinical studies have investigated the anti-diabetic effects of BMJ in humans [58-62], however, long-term studies testing the effects of BMJ on glucose and lipid metabolism, body weight as well as identifying the pharmacokinetics and effective dose of BMJ is warranted, before it can be recommended as an effective alternative and/or complementary therapy. Regardless of its therapeutic effects, use of BMJ with other hypoglycemic or hypolipidemic agents must be performed with caution and under medical supervision due to its hypoglycemic properties [63,64] and excessive consumption must be avoided due to possible side effects such as diarrhea [61]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Escalating trends of obesity and associated type 2 diabetes (T2D) has prompted an increase in the use of alternative and complementary functional foods. Momordica charantia or bitter melon (BM) that is traditionally used to treat diabetes and complications has been demonstrated to alleviate hyperglycemia as well as reduce adiposity in rodents. However, its effects on human adipocytes remain unknown. The objective of our study was to investigate the effects of BM juice (BMJ) on lipid accumulation and adipocyte differentiation transcription factors in primary human differentiating preadipocytes and adipocytes. Commercially available cryopreserved primary human preadipocytes were treated with and without BMJ during and after differentiation. Cytotoxicity, lipid accumulation, and adipogenic genes mRNA expression was measured by commercial enzymatic assay kits and semi-quantitative RT-PCR (RT-PCR). Preadipocytes treated with varying concentrations of BMJ during differentiation demonstrated significant reduction in lipid content with a concomitant reduction in mRNA expression of adipocyte transcription factors such as, peroxisome proliferator-associated receptor gamma (PPARgamma) and sterol regulatory element-binding protein 1c (SREBP-1c) and adipocytokine, resistin. Similarly, adipocytes treated with BMJ for 48 h demonstrated reduced lipid content, perilipin mRNA expression, and increased lipolysis as measured by the release of glycerol. Our data suggests that BMJ is a potent inhibitor of lipogenesis and stimulator of lipolysis activity in human adipocytes. BMJ may therefore prove to be an effective complementary or alternative therapy to reduce adipogenesis in humans.
    Full-text · Article · Jun 2010 · BMC Complementary and Alternative Medicine
  • [Show abstract] [Hide abstract]
    ABSTRACT: L’hypertension artérielle représente un problème majeur de santé publique. Selon l’Organisation mondiale de la santé (OMS), plus de 20 % de la population mondiale souffre des anomalies de la pression artérielle. Les études pharmacologiques ont supporté l’usage traditionnel de nombreuses plantes médicinales utilisées dans la pharmacopée marocaine pour le traitement de l’hypertension. Ce travail présente une synthèse des études sur la phytothérapie de l’hypertension au Maroc. Hypertension is a serious public health problem. According to the World Health Organisation (WHO), more than 20% of the world’s population has abnormal arterial blood pressure. Pharmacological investigations have supported the traditional use of several medicinal plants from the Moroccan pharmacopoeia for the treatment of hypertension. This review addresses a bibliographic survey of the study of hypertension phytotherapy in Morocco.
    No preview · Article · Apr 2009 · Phytotherapie
Show more