Article

Asymptomatic circulation of HEV71 in Norway. Virus Res

Charles University in Prague, Praha, Praha, Czech Republic
Virus Research (Impact Factor: 2.32). 02/2007; 123(1):19-29. DOI: 10.1016/j.virusres.2006.07.015
Source: PubMed

ABSTRACT

Widespread circulation of human enterovirus 71 was discovered in a prospective study of fecal samples obtained from healthy Norwegian children. Molecular characterization of the virus determined that it belonged to genotype C1. Complete sequencing of this strain, HEV71 804/NO/03, revealed differences in the 5'UTR and polymerase with respect to more pathogenic genotypes that may explain its reduced neurovirulence.

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Available from: Elisabet Witsø
    • "Subsequently, SAFV has been found in stool1213141516171819, respiratory[20,21], sewage[22], cerebrospinal fluid, blood and myocardium samples[15], and seems to infect young children[23]. The distribution and associated symptoms of SAFV are still not well described, but SAFV has been reported in both asymptomatic and symptomatic infections, as is also the case for other human picornaviruses such as enteroviruses and pare- choviruses[24,25]. Given the associated symptoms and diabetogenic potential of cardioviruses in rodents, and of related viruses in the picornaviridae family in humans, it is of interest to study the potential prospective association of SAFV with reported symptoms of disease and with development of islet autoimmunity and type 1 diabetes. "
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    • "In Europe, large outbreaks of polio-like disease caused by EV71 occurred in Bulgaria in 1975 and in Hungary in 1978. Thereafter, EV71 did not attract major attention until recently, when widespread asymptomatic circulation and detection from isolated neurological cases and minor outbreaks were reported from several European countries [5]–[8]. No major outbreaks have so far occurred in Europe. "
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    ABSTRACT: Enterovirus 71 (EV71) is an emerging human pathogen causing massive epidemics of hand, foot and mouth disease with severe neurological complications in Asia. EV71 also circulates in Europe, however it does not cause large outbreaks. The reason for distinct epidemiological patterns of EV71 infection in Europe and Asia and the risk of EV71 epidemic in Europe and Russia remain unknown. Seroepidemiology of EV71 and molecular epidemiology of occasional EV71 isolates were studied to explore circulation of EV71 in Russia. In six regions of Russian Federation, seroprevalence of EV71 in sera collected in 2008 ranged from 5% to 20% in children aged 1-2 years and from 19% to 83% in children aged 3-5 years. The seroprevalence among elder children was significantly higher (41-83% vs. 19-27%) in Asian regions of Russia. EV71 strains identified in Russia in 2001-2011 belonged to subtypes C1 and C2, while genotype C4 that was causing epidemics in Asia since 1998 emerged in 2009 and became dominant in 2013.
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