Macrophage activation by polysaccharide biological response modifier isolated from Aloe vera L. var. chinensis (Haw.) Berg

Article · December 2006with167 Reads
DOI: 10.1016/j.intimp.2006.04.013 · Source: PubMed
Abstract
A mannose-rich polysaccharide biological response modifier (BRM), derived from Aloe vera L. var. chinensis (Haw.) Berg., was demonstrated to be a potent murine B- and T-cell stimulator in our previous study. We here report the stimulatory activity of PAC-I on murine peritoneal macrophage. The polysaccharide when injected into mice enhanced the migration of macrophages to the peritoneal cavity. Peritoneal macrophage when treated by PAC-I in vitro had increased expression of MHC-II and FcgammaR, and enhanced endocytosis, phagocytosis, nitric oxide production, TNF-alpha secretion and tumor cell cytotoxicity. The administration of PAC-I into allogeneic ICR mice stimulated systemic TNF-alpha production in a dose-dependent manner and prolonged the survival of tumor-bearing mice. PAC-I is thus a potent stimulator of murine macrophage and the in vitro observed tumoricidal properties of activated macrophage might account for the in vivo antitumor properties of PAC-I. Our research findings may have therapeutic implications in tumor immunotherapy.
  • ...Also, experiments in vitro regarding stimulation of macrophages in the damaged tissues have shown that the existing mannose sugar in aloe vera compound stimulates these cells for producing cytokines and progress in some phases of wound healing after connection to the given receptor locating on surface of skin macrophages. In this sense, Trade Name of Acemenan has been assumed as a therapeutic compound for a group of polysaccharides enriched with mannose in aloe vera mucilage [55]. Atiba et al. (2011) showed that oral dosage of aloe vera mucilage might increase production of bFGF and TGF-í µí»½1 in place of wound on skin of rats, which had been exposed under a type of radiation [43]. ...
  • ...Also, experiments in vitro regarding stimulation of macrophages in the damaged tissues have shown that the existing mannose sugar in aloe vera compound stimulates these cells for producing cytokines and progress in some phases of wound healing after connection to the given receptor locating on surface of skin macrophages. In this sense, Trade Name of Acemenan has been assumed as a therapeutic compound for a group of polysaccharides enriched with mannose in aloe vera mucilage [55]. Atiba et al. (2011) showed that oral dosage of aloe vera mucilage might increase production of bFGF and TGF-í µí»½1 in place of wound on skin of rats, which had been exposed under a type of radiation [43]. ...
  • ...Its gel can help to stimulate the physique's immune method[3]. Aloe veracontain one-of-akind equivalent to saponins, anthraquinones, mucopolysaccharides, steroids, nutrients and glucomannans[4]. Aloe plant comprises 25 percentage of solid fraction that include sugars. ...
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