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SLITRK1 mutations in trichotillomania
SZu
¨
chner
1,2
, ML Cuccaro
1,2
, KN Tran-Viet
1
, H Cope
1
, RR Krishnan
2
, MA Pericak-Vance
1
, HH Wright
3
and A Ashley-Koch
1
1
Center for Human Genetics, Duke University Medical Center, Durham, NC, USA;
2
Department of Psychiatry and Behavioral
Sciences, Duke University Medical Center, Durham, NC, USA and
3
WS Hall Psychiatric Institute, University of South Carolina,
Columbia, SC, USA
Molecular Psychiatry (2006) 11, 887. doi:10.1038/sj.mp.4001898
Sequencing traces from the SLITRK1 gene showing normal sequence at top and SLITRK1 variant sequence
with a serine (S) to a glycine (G) amino-acid substitution at bottom. This SLITRK1 variant was identified in a
nuclear family, where two carriers exhibited trichotillomania. Photo of an anonymous trichotillomania
patient demonstrates the severity of symptoms that may be experienced. For more information on this topic,
please refer to article by Zu
¨
chner et al. on pages 888–889.
Molecular Psychiatry (2006) 11, 887
&
2006 Nature Publishing Group All rights reserved 1359-4184/06
$
30.00
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