Article

Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma

Centre for the Study of Liver Disease and Departments of Surgery, The University of Hong Kong, Queen Mary Hospital, L9-55, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China.
British Journal of Cancer (Impact Factor: 4.84). 11/2006; 95(8):1050-5. DOI: 10.1038/sj.bjc.6603399
Source: PubMed

ABSTRACT

Tumour recurrence and metastases of hepatocellular carcinoma (HCC) after hepatectomy are the major obstacles of long-term survival. The present study investigated the clinicopathological significance of a possible metastasis regulator Six1 in HCC patients who were undergone hepatectomy. Seventy-two pairs of RNA and 103 pairs of protein from tumour and adjacent nontumour liver tissues of HCC patients were examined. About 85 and 60% of HCC tumour tissues were found to overexpress Six1 mRNA and protein, respectively, compared with nontumour liver tissues. No Six1 protein was detected in HCC nontumour liver tissues and normal liver tissues. Increased Six1 protein expression in HCC patients was significantly correlated with pathologic tumour-node-metastasis (pTNM) stage (P=0.002), venous infiltration (P=0.004) and poor overall survival (P=0.0423). We concluded that Six1 is frequently overexpressed in HCC patients and elevated Six1 protein in HCC patients may be an indication of advanced stage and poor overall survival after hepatectomy.

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Available from: Kwan Man, May 23, 2014
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    • "Th is homeodomain transcription factor has been implicated in tumor progression and embryogenesis[17,18]. Six1 stimulates proliferation and survival of progenitor cells during normal development[19,20]which loss of its function leads to a reduction in size or the absence of various organs, because of a decrease in cell proliferation and increase in apoptosis[16,18,21]. Recent studies showed that Six1 overexpression is associated with a poor prognosis in numerous cancers including ovarian cancer, hepatocellular carcinoma, and cervical cancers[8,22]. Th e overexpression of Six1 protein likely contributes epithelial carcinogenesis by increasing of proliferation and decreasing apoptosis[23], or genomic instability[24]. "
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    Full-text · Article · Dec 2015 · Bosnian journal of basic medical sciences / Udruzenje basicnih mediciniskih znanosti = Association of Basic Medical Sciences
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    • "Behbakht et al. suggested that SIX1 might contribute to ovarian epithelial carcinogenesis by simultaneously increasing proliferation and decreasing TRAIL-mediated apoptosis (Behbakht et al., 2007). Ng et al. reported that increased SIX1 protein expression in tumors of hepatocellular carcinoma patients was significantly correlated with pTNM stage, venous infiltration and poor overall survival (Ng et al., 2006). These data indicated that SIX1 potentially contributed to the tumorigenicity of many cancers. "
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    Full-text · Article · Aug 2014 · Experimental and Molecular Pathology
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    • "In regard to prognosis, Ng et al. reported that increased SIX1 expression in human hepatocellular carcinoma patients was significantly correlated with the pTNM stage, venous infiltration and poor overall survival (Ng et al., 2006). Our previous study also indicated that SIX1 overexpression was significantly related with the late stage and metastasis of PDAC (Jin et al., 2013). "
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