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Subchronic 90-day oral (Gavage) toxicity study of a Luo Han Guo mogroside extract in dogs

Department of Pharmacology, Pharmaceutical Institute of Guilin Medical College, Guilin, Guangxi, People's Republic of China.
Food and Chemical Toxicology (Impact Factor: 2.9). 01/2007; 44(12):2106-9. DOI: 10.1016/j.fct.2006.07.023
Source: PubMed

ABSTRACT

A combined 28-day and 90-day oral (Gavage) study was conducted in male and female dogs to investigate the safety of PureLo, a non-caloric sweetener derived from the Chinese fruit Luo Han Guo, which achieves its sweetness from the presence of triterpene glycosides known as mogrosides. Three dogs of each sex were administered 10 mL/kg bw/day of either an aqueous solution providing 3000 mg/kg bw/day of PureLo or distilled water for either 28 days or 90 days. Measurements included clinical observations, body weight, food consumption, hematology, blood chemistry, urinalysis, gross necropsy, organ weight, and histopathology. There were no significant adverse effects on any of these measures. Based on the lack of toxicological effects in the study, the NOAEL for PureLo is 3000 mg/kg bw/day when administered to dogs by Gavage for 90 consecutive days.

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    • "The primary active components of Luohanguo are the mogrosides, a group of terpene glycosides that are estimated to be about 300 times as sweet as sucrose (Kasai et al., 1989). The mogrosides produce a sweet taste in Chinese herbal Kombucha prepared using Luohango extracts and have been approved for use as dietary supplements in Japan, the United States, New Zealand and Australia (Qin et al., 2006). Chrysanthemum and green tea contain effective antiviral compounds such as chlorogenic acid and various polyphenolics, which can inhibit the reproduction of HIV, HBV, and the influenza virus, among others (Imanishi et al., 2002;Nakayama et al., 1993;Xu et al., 2008). "
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    • "Its non-caloric properties and effects on the cancer chemopreventive and antioxidant, being used as sweetening are being used as sweetening agents for the patients with diabetes mellitus, adiposis, hypertension, heart disease and so on. Luohanguo products have been approved as dietary supplements in Japan, the United States, New Zealand and Australia [4]. With the rapid rise in market demand, Luohanguo extracts have increased rapidly from two tons in 2002 to 60┬átons in 2007, becoming one of the fastest growing traditional Chinese medicine extracts. "
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