Effects of dorsal and ventral vertical lobe electrolytic lesions on spatial learning and locomotor activity in Sepia officinalis

Laboratoire de Physiologie du Comportement des Cephalopodes, Universite de Caen Basse-Normandie, Caen, France.
Behavioral Neuroscience (Impact Factor: 2.73). 11/2006; 120(5):1151-8. DOI: 10.1037/0735-7044.120.5.1151
Source: PubMed


This study aims to analyze the effects of electrolytic lesion, restricted to either the ventral or the dorsal parts of the vertical lobe (VL), on the behavior of cuttlefish (Sepia officinalis). Two behavioral tests were performed on sham-operated and lesioned cuttlefish: assessment of locomotor activity in an open field and determination of spatial learning abilities in a T maze. The results showed that ventral lesions of the VL led to marked impairment in the acquisition of spatial learning, whereas dorsal lesions of the VL increased locomotor activity in the open field and impaired long-term retention of spatial learning. This study establishes for the first time the existence of distinct functions in the ventral and the dorsal parts of the VL in cephalopods.

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Available from: Christelle Jozet-Alves, Nov 01, 2014
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    • "In fact, Hochner et al.64 found that the octopus vertical lobe shows two different types of mechanisms for induction of long-term potentiation as in different parts of the vertebrate hippocampus. One type appears to depend on the postsynaptic response, while the other does not require a strong postsynaptic response for induction.64 Our results could suggest that, like serotonin,21 ACh may act as a neuromodulator in a reinforcing/reward signaling system. "
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    ABSTRACT: Acetylcholine, the first neurotransmitter to be identified in the vertebrate frog, is widely distributed among the animal kingdom. The presence of a large amount of acetylcholine in the nervous system of cephalopods is well known from several biochemical and physiological studies. However, little is known about the precise distribution of cholinergic structures due to a lack of a suitable histochemical technique for detecting acetylcholine. The most reliable method to visualize the cholinergic neurons is the immunohistochemical localization of the enzyme choline acetyltransferase, the synthetic enzyme of acetylcholine. Following our previous study on the distribution patterns of cholinergic neurons in the Octopus vulgaris visual system, using a novel antibody that recognizes choline acetyltransferase of the common type (cChAT), now we extend our investigation on the octopus central brain mass. When applied on sections of octopus central ganglia, immunoreactivity for cChAT was detected in cell bodies of all central brain mass lobes with the notable exception of the subfrontal and subvertical lobes. Positive varicosed nerves fibers where observed in the neuropil of all central brain mass lobes.
    Full-text · Article · Jul 2012 · European journal of histochemistry: EJH
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    • "This is also an effective means to control for individual variation among wild-caught animals. Naive adult animals were randomly assigned to receive the CS+ or Explicitly Unpaired train- Table I. – Comparison of learning studies in Coleoids and Nautiloids: 1: [Crook et al. 2009]; 2: [Crook &Basil 2008a] 3: [Wells &Wells 1956] 4: [Wells & Wells 1958] 5: [Chase & Wells 1986] 6: [Boal 1991] 7: [Boal et al. 2000] 8: [Sutherland 1963] 9: [Dews 1959] 10: [Crancher et al. 1972] 11: [Wells 1964a] 12: [Mather 1991] 13: [Forsythe & Hanlon 1997]14: [Graindorge et al. 2006] 15: [Hvorecny et al. 2007] 16: [Fiorito & Scotto 1992] 17 [Fiorito & Chichery 1995] 18: [Long et al. 1989] 19: [Flores 1983] 20: [Allen et al. 1985] 21: [Karson 2003] 22: [Messenger 1973] 23: [Messenger 1977] 24: [Alves et al. 2007] 25: [Alves et al. 2008]. "

    Full-text · Article · Jan 2012 · Vie et Milieu
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    • "The vertical lobe of the cuttlefish brain is known to share cellular processes (long-term potentiation, Hochner et al. 2003) and structural (sequences of intersected matrices, Young 1991) and functional properties (implication in locomotor activity level and memory, Graindorge et al. 2006) with the hippocampus. Electrolytic lesions of the ventral part of the vertical lobe induced impairments in the acquisition of a comparable spatial task (Graindorge et al. 2006). Thus, it would be interesting to undertake comparative studies of the vertical lobe between males and females. "
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    ABSTRACT: Evidence of sex differences in spatial cognition have been reported in a wide range of vertebrate species. Several evolutionary hypotheses have been proposed to explain these differences. The one best supported is the range size hypothesis that links spatial ability to range size. Our study aimed to determine whether male cuttlefish (Sepia officinalis; cephalopod mollusc) range over a larger area than females and whether this difference is associated with a cognitive dimorphism in orientation abilities. First, we assessed the distance travelled by sexually immature and mature cuttlefish of both sexes when placed in an open field (test 1). Second, cuttlefish were trained to solve a spatial task in a T-maze, and the spatial strategy preferentially used (right/left turn or visual cues) was determined (test 2). Our results showed that sexually mature males travelled a longer distance in test 1, and were more likely to use visual cues to orient in test 2, compared with the other three groups. This paper demonstrates for the first time a cognitive dimorphism between sexes in an invertebrate. The data conform to the predictions of the range size hypothesis. Comparative studies with other invertebrate species might lead to a better understanding of the evolution of cognitive dimorphism.
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