Smaller Neocortical Gray Matter and Larger Sulcal Cerebrospinal Fluid Volumes in Neuroleptic-Naive Women With Schizotypal Personality Disorder

Harvard University, Cambridge, Massachusetts, United States
Archives of General Psychiatry (Impact Factor: 14.48). 11/2006; 63(10):1090-100. DOI: 10.1001/archpsyc.63.10.1090
Source: PubMed


Structural brain abnormalities, including larger cerebrospinal fluid (CSF) volumes, have been observed in men diagnosed as having schizotypal personality disorder (SPD).
To determine whether women with SPD have abnormalities similar to those of men with SPD and to elucidate specific SPD regional volume deficits and symptom correlations.
Naturalistic study. Setting and
Thirty neuroleptic-naive women with SPD and 29 female control subjects, both recruited from the community. Participants were group matched for age, parental socioeconomic status, handedness, and IQ.
A new segmentation method was applied to magnetic resonance images to automatically parcel the images into CSF, gray matter, and white matter. The neocortex was manually separated from subcortical and other nonneocortical structures. Voxel-based morphometry was applied to determine global and regional volume deficits.
Left and right neocortical gray matter, white matter, and CSF relative volumes as well as clinical symptoms from the Structured Interview for Schizotypy and the Schizotypal Personality Questionnaire-Brief Version.
Smaller left (3.84%) and right (3.83%) neocortical gray matter relative volumes associated with larger left (9.66%) and right (9.61%) sulcal CSF relative volumes were found in women with SPD compared with controls. Voxel-based morphometry showed that the neocortical deficits in SPD were especially prominent in the left superior and middle temporal gyri, left inferior parietal region with postcentral gyrus, and right superior frontal and inferior parietal gyri. In the SPD group, larger lateral ventricle volumes correlated with more severe symptoms on the Structured Interview for Schizotypy and the Schizotypal Personality Questionnaire-Brief Version.
The smaller neocortical gray matter volume and larger sulcal CSF volume provide evidence of the brain basis of this personality disorder and emphasize the communality of brain abnormalities in the schizophrenia spectrum.

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    • "It cannot be ruled out that our study ascertained a largely schizotypal population that is not so much at ultra-high risk for developing schizophrenia but is manifesting a more stable syndrome indicative of a genetic liability to schizophrenia. MRI studies of subjects with schizotypal personality disorder showed gray matter reductions in fronto-temporal regions similar to patients with schizophrenia (Kawasaki et al., 2004; Koo et al., 2006). "
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    • "Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 1997; Dickey et al 2000; Koo et al 2006). Temporal cortex volume reductions, particularly in the superior temporal gyrus (STG) have been consistently reported in schizophrenia (Davidson and Heinrichs 2003; Downhill et al 2001; Gur et al 2000; Hirayasu et al 2000; Shenton et al 2001; Wright et al 2000). "
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