Boffetta PEpidemiology of peritoneal mesothelioma: a review. Ann Oncol 18: 985-990

International Agency for Research on Cancer, Lyon, France.
Annals of Oncology (Impact Factor: 7.04). 07/2007; 18(6):985-90. DOI: 10.1093/annonc/mdl345
Source: PubMed


The epidemiology of peritoneal mesothelioma is complicated by possible geographic and temporal variations in diagnostic practices.
The incidence rates in industrialized countries range between 0.5 and three cases per million in men and between 0.2 and two
cases per million in women. Exposure to asbestos is the main known cause of peritoneal mesothelioma. Results on peritoneal
mesothelioma have been reported for 34 cohorts exposed to asbestos, among which a strong correlation was present between the
percentages of deaths from pleural and peritoneal mesothelioma (correlation coefficient 0.8, P < 0.0001). Studies of workers exposed only or predominantly to chrysotile asbestos resulted in a lower proportion of total
deaths from peritoneal mesothelioma than studies of workers exposed to amphibole or mixed type of asbestos. Cases of peritoneal
mesothelioma have also been reported following exposure to erionite and Thorotrast, providing further evidence of common etiological
factors with the pleural form of the disease. The role of other suspected risk factors, such as simian virus 40 infection
and genetic predisposition, is unclear at present. Control of asbestos exposure remains the main approach to prevent peritoneal

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    • "To date, no standard staging system exists for peritoneal mesothelioma, although experimental [6] staging systems have been proposed. Pericardial MM [1] [5] is the least common form, producing symptoms such as nausea, chest pain, and dyspnoea. Prognosis is poor in all 3 forms of MM. "
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    ABSTRACT: Purpose: Malignant mesothelioma (MM) rarely arises from the peritoneum. We describe the 1st such case which metastasised to the head and neck region (tongue). Methods: We briefly surveyed the American Surveillance Epidemiology and End Results (SEER) database, and the British Cancer Research UK database for the latest trends in MM incidence. We did a systematic Pubmed search for other MM reports with tongue metastases. Results and presentation of case: American and British data show that MM incidence in men has stabilised in the last 10 years, earlier than previously predicted. The tongue is an unusual site for MM spread, with ours being only the 9th such case described. Our summary of published cases of MM metastasising to the tongue brings out our patient to be the least in age(35 years), and the only one to have peritoneal MM as the primary. Seven of the 9 cases were male. Only 2 had a recorded history of exposure to asbestos. All 9 patients had the epithelioid subtype of MM. Surgery was done as the exclusive reported intervention in 4 out of the 9 patients. Only 2 cases received radiotherapy, amongst whom, only our patient responded. Conclusions: Metastasis of MM to the tongue is rare and usually in the uncommon context of MM with multiple sites of extra-thoracic or extra-abdominal spread. We have described a unique clinical manifestation of a rare subtype of mesothelioma. Moreover, we have tabulated and summarised details (including responses to surgery or/and radiotherapy) regarding all reported cases of mesotheliomas with tongue metastasis.
    Full-text · Article · Feb 2016 · Annals of Medicine and Surgery
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    • "Peritoneal mesotheliomas account for only 30% of diagnoses [2] . Like pleural mesothelioma, the pathogenesis in many patients is linked to asbestos exposure by ingestion or through lymphatic spread of fibers [3] [4] . We present a case of an incidentally discovered malignant peritoneal mesothelioma which grew during pregnancy and resolved following delivery. "

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    • "Malignant peritoneal mesothelioma is a rare cancer with poor patient survival. The incidence of peritoneal mesothelioma worldwide is approximately one case in a population of 4-5 million,[1] with an incidence of all mesotheliomas being 1 in 1 million.[1] However, the incidence rates in industrialized countries are greater and range between 0.5 and 3 cases per million in men and between 0.2 and 2 cases per million in women.[1] "
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    ABSTRACT: This report highlights that pleural and peritoneal mesothelioma can occur without direct asbestos exposure as was seen in our young patient. The patient had indirect exposure for as short as 3 months as a child, 15 years earlier, when she was residing with her miner father in the district of Jharia, Jharkhand, which is an asbestos-rich mining area in eastern India. The patient presented with chest pain and breathlessness. Chest X-ray showed opaque right hemithorax. Typical contrast- computed tomography (CECT) enhanced radiological features included nodular, soft-tissue attenuation and homogenously enhancing rind-like mass causing scalloping of the underlying lung and liver. Similar lesions were also found involving the pelvis. Diagnosis of malignant mesothelioma was confirmed on lung biopsy. Under-reporting of exposure is usual because it is unrecognized by both patients and investigators.
    No preview · Article · Jun 2014 · Journal of Clinical Imaging Science
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