Di PG, De CP.. Phosphoinositides in cell regulation and membrane dynamics. Nature 443: 651-657

Department of Pathology and Cell Biology, The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York 10032, USA.
Nature (Impact Factor: 41.46). 11/2006; 443(7112):651-7. DOI: 10.1038/nature05185
Source: PubMed


Inositol phospholipids have long been known to have an important regulatory role in cell physiology. The repertoire of cellular processes known to be directly or indirectly controlled by this class of lipids has now dramatically expanded. Through interactions mediated by their headgroups, which can be reversibly phosphorylated to generate seven species, phosphoinositides play a fundamental part in controlling membrane-cytosol interfaces. These lipids mediate acute responses, but also act as constitutive signals that help define organelle identity. Their functions, besides classical signal transduction at the cell surface, include regulation of membrane traffic, the cytoskeleton, nuclear events and the permeability and transport functions of membranes.

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    • ") (Boronenkov et al., 1998; Osborne et al., 2001; Watt et al., 2002; Mortier et al., 2005; Di Paolo and De Camilli, 2006; Mellman et al., 2008). The genome is packaged into chromatin (Margueron and Reinberg, 2010). "
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    ABSTRACT: Phosphatidylinositol (PI) metabolism represents the core of a network of signaling pathways which modulate many cellular functions including cell proliferation, cell differentiation, apoptosis and membrane trafficking. An array of kinases, phosphatases and lipases acts on PI creating an important number of second messengers involved in different cellular processes. Although, commonly, PI signaling was described to take place at the plasma membrane, many evidences indicated the existence of a PI cycle residing in the nuclear compartment of eukaryotic cells. The discovery of this mechanism shed new light on many nuclear functions, such as gene transcription, DNA modifications and RNA expression. As these two PI cycles take place independently of one another, understanding how nuclear lipid signaling functions and modulates nuclear output is fundamental in the study of many cellular processes. This article is protected by copyright. All rights reserved.
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    • "The PI(4)P on the LCV allows the anchoring of PI(4)P-binding effectors such as SidM/DrrA, SidC and SdcA, which may compartmentalize the activity of these effectors to the surface of the LCV (Brombacher et al., 2009; Ragaz et al., 2008; Weber et al., 2006). Enriched PI(4)P may also mimic the lipid composition of the cis-Golgi compartment (Di Paolo and De Camilli, 2006; Odorizzi et al., 2000), making the LCV a " natural " recipient compartment for the incoming ER-derived vesicles. L. pneumophila also interferes with the biosynthesis of diacylglycerol (DAG) and phosphatidic acid (PA) in host cells (Viner et al., 2012) but the importance of such manipulation is not clear. "
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    • "Labelling of PI(4,5)P2 showed that this lipid is present only on the FP membrane. This by itself is highly unusual, as PI(4,5)P2 is normally found throughout the plasma membrane[87]. This spatial restriction of PI(4,5)P2 might reflect the fact that in T. brucei, endocytosis occurs only on this membrane. "
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