Recurrent aphthous stomatitis as an expression of pathergy in atopics

Unit of Immunodermatology, Local Health Center no. 16, University of Padua, Padua, Italy.
Acta dermatovenerologica Alpina, Panonica, et Adriatica 10/2006; 15(3):144-7.
Source: PubMed


Recurrent Aphthous Stomatitis (RAS) may be part of the "atopic background". Recently it has been reported that aphtous stomatitis could be an expression of atopic diathesis. The aim of this study is to verify whether the prevalence of posttraumatic aphthae is higher in patients with RAS and atopic diathesis than in patients with RAS without atopy.
In the past three years 39 new patients between 14 and 56 years of age and affected by idiopathic RAS have been observed. Atopic status and history of posttraumatic aphthosis were evaluated in all patients.
The results appear to show that in our population the prevalence of posttraumatic aphthae is higher among atopic patients.
Not only RAS but also pathergy could be considered an expression of the rich clinical/ symptomatic constellation of atopic diathesis.

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Available from: Pietro Gallina, Aug 14, 2014
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    • "The potential trigger factors include: genetic predisposition, viral and bacterial infections, food allergies, vitamin and microelement deficiencies, systemic diseases (e.g., celiac disease, Crohn’s disease, ulcerative colitis, AIDS), increased oxidative stress, hormonal defects, mechanical injuries and anxiety (Bilgili et al. 2013; Field and Allan 2003; Koybasi et al. 2006; McCullough et al. 2007; Natah et al. 2004; Scully and Porter 2008). Recently, also the atopic background of the condition has been suggested (Veller-Fomasa and Gallina 2006). In genetically predisposed patients, the effect of certain trigger factors initiates the cascade of proinflammatory cytokines, directed against selected regions of the oral mucosa. "
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    ABSTRACT: Recurrent aphthous stomatitis (RAS; recurrent aphthous ulcers; canker sores) belongs to the group of chronic, inflammatory, ulcerative diseases of the oral mucosa. Up to now, the etiopathogenesis of this condition remains unclear; it is, however, considered to be multifactorial. The results of currently performed studies indicate that genetically mediated disturbances of the innate and acquired immunity play an important role in the disease development. Factors that modify the immunologic response in RAS include: food allergies, vitamin and microelement deficiencies, hormonal and gastrointestinal disorders (e.g., celiac disease, Crohn's disease, ulcerative colitis), some viral and bacterial infections, mechanical injuries and stress. In this paper, we presented the main etiopathogenetic factors of RAS with a special emphasis on the mechanisms of the immune response modification. Moreover, we discussed the crucial clinical symptoms and types of RAS together with epidemiologic data based on the current medical literature reports and our own observations.
    Full-text · Article · Nov 2013 · Archivum Immunologiae et Therapiae Experimentalis
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    ABSTRACT: Abstract: Recurrent Aphthous Stomatitis (RAS) is a chronic, multi-factorial oral inflammatory disease that continues to present a clinical problem without a solution. Even though the etiopathogeny of RAS is still unknown, it has been classified as an auto-inflammatory disease based on its relationship with a possible dysfunction of the innate immunological response without evidence of alterations in the adaptive immune reaction that, in association with a dysfunction of the epithelial barrier, are probably involved in the emergence and evolution of ulcerated lesions. In this type of complex disease, the combination of environmental factors and genes of low frequency is most likely responsible for the establishment of the conditions that promote the development of the phenotype involved. In such cases, since the genetic factors are heterogeneous, the cause of the disease may be different for each individual. This hinders the precise identification of the reasons and the establishment of a unique therapeutic protocol which functions in all cases. In this scenario, the application of personalized medicine will be of fundamental importance. Knowledge of the altered signaling pathways associated with each individual will be indispensable in developing personalized treatments. With the current technology, there exists the possibility of analyzing all the human transcripts in individual samples to identify the specific alterations associated with RAS of each patient.
    No preview · Chapter · Oct 2015