The Intestinal Microvasculature as a Therapeutic Target in Inflammatory Bowel Disease

ArticleinAnnals of the New York Academy of Sciences 1072(1):78-97 · September 2006with6 Reads
Impact Factor: 4.38 · DOI: 10.1196/annals.1326.003 · Source: PubMed

    Abstract

    Chronic inflammation is a complex biologic process which involves immune as well as non-immune cells including the microvasculature and its endothelial lining. Growing evidence suggests that the microvasculature plays an integral role in the pathophysiology of inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis). The microvasculature contributes to chronic inflammation through altered leukocyte recruitment, impaired perfusion, and angiogenesis leading to tissue remodeling. These diverse areas of IBD microvascular biology represent therapeutic targets that are currently undergoing investigation.