Baclofen-associated encephalopathy in a hemodialysis patient with hiccups

Servicio de Nefrología y Trasplante Renal, Hospital Clinic, Barcelona.
Nefrologia: publicacion oficial de la Sociedad Espanola Nefrologia (Impact Factor: 1.22). 02/2006; 26(4):486-8.
Source: PubMed


Baclofen is a centrally acting gamma-ammino butyric acid agonist that is used like muscular relaxant in disorders with spasticity and intractable hiccups. Although encouraging and safe results were provided 5 mg/day in hemodialysis patients, his pharmacokinetic and pharmacodinamic properties are not well known in end stage renal disease. We present here the case of a hemodialysis patient with intractable hiccups who developed baclofen-associated encephalopathy with this recommended dose.

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