Intensive Insulin Therapy in Mixed Medical/Surgical Intensive Care Units: Benefit Versus Harm

Department of Intensive Care Medicine, University Hospital Gasthuisberg, University of Leuven, B-3000 Leuven, Belgium.
Diabetes (Impact Factor: 8.1). 11/2006; 55(11):3151-9. DOI: 10.2337/db06-0855
Source: PubMed


Intensive insulin therapy (IIT) improves the outcome of prolonged critically ill patients, but concerns remain regarding potential harm and the optimal blood glucose level. These questions were addressed using the pooled dataset of two randomized controlled trials. Independent of parenteral glucose load, IIT reduced mortality from 23.6 to 20.4% in the intention-to-treat group (n = 2,748; P = 0.04) and from 37.9 to 30.1% among long stayers (n = 1,389; P = 0.002), with no difference among short stayers (8.9 vs. 10.4%; n = 1,359; P = 0.4). Compared with blood glucose of 110-150 mg/dl, mortality was higher with blood glucose >150 mg/dl (odds ratio 1.38 [95% CI 1.10-1.75]; P = 0.007) and lower with <110 mg/dl (0.77 [0.61-0.96]; P = 0.02). Only patients with diabetes (n = 407) showed no survival benefit of IIT. Prevention of kidney injury and critical illness polyneuropathy required blood glucose strictly <110 mg/day, but this level carried the highest risk of hypoglycemia. Within 24 h of hypoglycemia, three patients in the conventional and one in the IIT group died (P = 0.0004) without difference in hospital mortality. No new neurological problems occurred in survivors who experienced hypoglycemia in intensive care units (ICUs). We conclude that IIT reduces mortality of all medical/surgical ICU patients, except those with a prior history of diabetes, and does not cause harm. A blood glucose target <110 mg/day was most effective but also carried the highest risk of hypoglycemia.

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Available from: Roger Bouillon, Nov 15, 2015
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    • "To assess the patient comprehensively, nurses must also identify unpleasant symptoms, such as delirium (Ely et al., 2001; Girard et al., 2010), depression (Idemoto, 2005; Li and Puntillo, 2006) and fatigue (Lerdal et al., 2009; Chen et al., 2010). The syndrome critical illness polyneuropathy/myopathy (CIP/CIM) (Van den Berghe et al., 2006; Hermans et al., 2007) may also influence nurses' assessments. In this study, we refer to CIP/CIM as an unpleasant symptom. "
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    ABSTRACT: To describe intensive care nurses' perceptions and assessments of unpleasant symptoms and signs in mechanically ventilated and sedated adult intensive care patients. Mechanically ventilated patients are unable to express themselves verbally and depend upon nurses to control their symptoms by understanding their unpleasant experiences, such as pain, anxiety or delirium and interpret the relevant signs. Nurses must have enough knowledge to adjust their analgesics and sedatives appropriately and to avoid under- or oversedation. A cross-sectional survey design. A study with a self-administrated questionnaire was undertaken in October 2007 to February 2008, with a convenience sample of 183 intensive care nurses in Norway. The questionnaire was completed by 86 (47%) nurses. Most perceived that critical illness polyneuropathy/myopathy occurred frequently. Half the nurses underestimated pain, anxiety and delirium. Signs such as a response to contact, cough reflex, wakefulness and muscle tone were considered most important in assessing oversedation. Agitation, facial grimacing, tube intolerance and wakefulness were considered most important in assessing undersedation. The Comfort Scale and Adoption of the Intensive Care Environment corresponded best to the signs identified by the nurses. The nurses underestimated unpleasant symptoms other than critical illness polyneuropathy/myopathy. A further mapping of patients' experiences should be conducted, with an emphasis on the more 'silent' distressing symptoms. Further tools to facilitate the communication of consciousness levels and the intolerance of unpleasant symptoms must be developed and implemented. A deeper understanding of unpleasant symptoms and signs focused in learning activities may help nurses to recognize patients' early problems and allow targeted interventions. A more active stimulus-response assessment of ICU patients is required to detect oversedation, critical illness polyneuropathy/myopathy and hypoactive delirium. Assessment tools should reflect both the patient's tolerance of various unpleasant symptoms and the level of consciousness.
    Full-text · Article · Jul 2013 · Nursing in Critical Care
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    • "Our findings support the results of previous studies that have focused on understanding the association between the presence of DM at ICU admission, glycaemia, and ICU mortality [7,8,16-19,31,32]. In all these studies, a stronger association between hyperglycaemia and ICU mortality was found in patients without DM, in comparison with patients with DM. "
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    ABSTRACT: Introduction: In critical illness, four measures of glycaemic control are associated with ICU mortality: mean glucose concentration, glucose variability, the incidence of hypoglycaemia (≤2.2 mmol/l) or low glucose (2.3 to 4.7 mmol/l). Underlying diabetes mellitus (DM) might affect these associations. Our objective was to study whether the association between these measures of glycaemic control and ICU mortality differs between patients without and with DM and to explore the cutoff value for detrimental low glucose in both cohorts. Methods: This retrospective database cohort study included patients admitted between January 2004 and June 2011 to a 24-bed medical/surgical ICU in a teaching hospital. We analysed glucose and outcome data from 10,320 patients: 8,682 without DM and 1,638 with DM. The cohorts were subdivided into quintiles of mean glucose and quartiles of glucose variability. Multivariable regression models were used to examine the independent association between the four measures of glycaemic control and ICU mortality, and for defining the cutoff value for detrimental low glucose. Results: Regarding mean glucose, a U-shaped relation was observed in the non-DM cohort with an increased ICU mortality in the lowest and highest glucose quintiles (odds ratio=1.4 and 1.8, P<0.001). No clear pattern was found in the DM cohort. Glucose variability was related to ICU mortality only in the non-DM cohort, with highest ICU mortality in the upper variability quartile (odds ratio=1.7, P<0.001). Hypoglycaemia was associated with ICU mortality in both cohorts (odds ratio non-DM=2.5, P<0.001; odds ratio DM=4.2, P=0.001), while low-glucose concentrations up to 4.9 mmol/l were associated with an increased risk of ICU mortality in the non-DM cohort and up to 3.5 mmol/l in the DM cohort. Conclusion: Mean glucose and high glucose variability are related to ICU mortality in the non-DM cohort but not in the DM cohort. Hypoglycaemia (≤2.2 mmol/l) was associated with ICU mortality in both. The cutoff value for detrimental low glucose is higher in the non-DM cohort (4.9 mmol/l) than in the DM cohort (3.5 mmol/l). While hypoglycaemia (≤2.2 mmol/l) should be avoided in both groups, DM patients seem to tolerate a wider glucose range than non-DM patients.
    Full-text · Article · Mar 2013 · Critical Care
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    • "These pathophysiologic changes have their impact on the course of anesthesia and surgery specially cardiac surgery and cardiopulmonary bypass [3]. Studies showed that a fraction of nondiabetic patients were found to have glucose intolerance due to the stressful situation of anesthesia and cardiopulmonary bypass [4] [5]. Recent studies showed that although tight euglycemic control has its beneficial effect on reducing neurological and infectious complications yet this was offset by the possibility of hypoglycemia which is more dangerous in case of general anesthesia in the short term view [6]. "
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    ABSTRACT: Background Blood glucose control is an important factor in improving outcome of diabetic patients undergoing cardiac surgery.Objective Is to estimate the relation between blood glucose control and perioperative outcomes in these patients.Study designProspective cohort study.Methods One hundred diabetic patients undergoing cardiac surgery, were divided equally into group I (control group) in whom no tight glycemic control was done and group II (study group) in which tight glycemic control was done. Patients in the study group received intra-operatively an infusion of rapidly acting insulin according to a modified protocol to keep blood glucose level between 80 and 110 mg/dl and continued in the ICU until complete recovery from anesthesia. Patients in the control group followed the same protocol of insulin infusion only if their peri-operative blood glucose level exceeded 180 mg/dl.ResultsThere was a rise of blood glucose level in the control group patients till the end of operations (mean level = 227 mg/dl). Mean blood glucose level before CPB was comparable in the two groups, but was significantly different after that until extubation. We reported three cases of delayed recovery in the control group compared to one case in the study group. We also recorded four cases of cardiac problems in group I compared to one case in group II (P = 0.044). There was statistically significant difference between groups regarding renal, neurological and surgical post-operative complications.Conclusion Tight glycemic control is recommended for better patient’s outcome after cardiac anesthesia.
    Preview · Article · Jan 2013 · Egyptian Journal of Anaesthesia
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