Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation

ArticleinTrends in cell biology 16(12):607-9 · January 2007with12 Reads
Impact Factor: 12.01 · DOI: 10.1016/j.tcb.2006.10.004 · Source: PubMed


    During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is involved in detaching fully formed coated pits from the membrane, and also propose a new role for dynamin earlier in the process at the point of invagination.