Augmentation of sertraline with prolonged exposure in the treatment of posttraumatic stress disorder

Duke University, Durham, North Carolina, United States
Journal of Traumatic Stress (Impact Factor: 2.72). 10/2006; 19(5):625-38. DOI: 10.1002/jts.20170
Source: PubMed


The present study was designed to determine whether augmenting sertraline with prolonged exposure (PE) would result in greater improvement than continuation with sertraline alone. Outpatient men and women with chronic PTSD completed 10 weeks of open label sertraline and then were randomly assigned to five additional weeks of sertraline alone (n = 31) or sertraline plus 10 sessions of twice-weekly PE (n = 34). Results indicated that sertraline led to a significant reduction in PTSD severity after 10 weeks but was associated with no further reductions after five more weeks. Participants who received PE showed further reduction in PTSD severity. This augmentation effect was observed only for participants who showed a partial response to medication.

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Available from: Shawn P Cahill
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    • "However, controlled studies investigating the efficacy of this combined treatment strategy are scarce. Rothbaum et al. (2006) examined the effect of adding prolonged exposure (PE; Foa & Rothbaum, 1998) for SSRI non-responders. PTSD patients were provided with 10 weeks of open-label sertraline and those who did not remit were then randomized to either receive five additional weeks of sertraline alone or with 10 sessions of twice weekly PE. "
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