Perspectives on current directions in the neurobiology of addiction disorders relevant to genetic risk factors

ArticleinCNS spectrums 11(11):855-62 · December 2006with1 Read
Impact Factor: 2.71 · Source: PubMed

    Abstract

    There is a significant heritability of drug addiction disorders, but potential genes that may underlie such vulnerability have not been clearly identified. Common neurobiological candidates for drug abuse include genes related to dopamine, opioid neuropeptide, and glutamate transmission that play important roles in drug reward and inhibitory control. This article provides an overview of genetic polymorphisms linked to these neurobiological systems, particularly in relation to psychostimulant- and opioid-addiction vulnerability.