Article

Health of Children Born as a Result of In Vitro Fertilization

Health Services Research, National Research and Development Centre for Welfare and Health, Helsinki, Finland.
PEDIATRICS (Impact Factor: 5.47). 12/2006; 118(5):1819-27. DOI: 10.1542/peds.2006-0735
Source: PubMed

ABSTRACT

The purpose of this study was to use nationwide registries to examine the health of children up to 4 years of age who were born as a result of in vitro fertilization.
Children born after in vitro fertilization (N = 4559) from 1996 to 1999 were monitored until 2003. Two control groups were selected from the Finnish Medical Birth Register as follows: all other children (excluding children born after ovulation induction) from the same period (N = 190,398, for study of perinatal health and hospitalizations) and a random sample of those children (n = 26,877, for study of health-related benefits). Mortality rates and odds ratios for perinatal outcomes, hospitalizations, health-related benefits, and long-term medication use were calculated.
Although the health of most in vitro fertilization children was good, such children had more health problems than other children. A total of 35.7% of in vitro fertilization children and 2.2% of control children were multiple births, and the health of multiple births was worse than that of singletons. Perinatal outcomes of in vitro fertilization children were worse and hospital episodes were more common than among control children. Risks for cerebral palsy and psychological and developmental disorders were increased. Among in vitro fertilization singletons, worse results for perinatal outcomes and hospitalizations, but no increased risk for specific diseases, were found. The health of in vitro fertilization multiple births was comparable to the health of control multiple births.
Reducing the number of transferred embryos would improve the health of in vitro fertilization children. Additional studies are needed to explain the poorer health of in vitro fertilization singletons, as well as follow-up studies to examine the health of in vitro fertilization children from 4 years onward.

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Available from: Reija Klemetti, Jan 08, 2015
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    • "Infants produced by ART are also significantly more likely to be admitted to a neonatal intensive care unit, to be hospitalized and to stay in hospital longer than their naturally conceived counterparts.19 Recent studies have also shown an increase in the hospitalization of ART offspring in infancy and early childhood compared with spontaneously conceived children, as well as abnormal patterns of retinal vascularization and an increase in the incidence of undescended testicles in boys conceived by ICSI.7374757677 "
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    • "The only cohort study in which a significant positive association between IVF and ASDs has been found [odds ratio (OR): 1.68, 95% confidence interval (CI): 1.11 –2.53] was based on a Finnish cohort (Klemetti et al., 2006) but the definition of the outcome was even less precise than in the previously mentioned studies. In addition to ASDs, practically all childhood developmental and psychiatric disorders were included (Klemetti et al., 2006). "
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    Preview · Article · Jan 2013 · Human Reproduction
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    • "According with Klemetti et al., stillbirths are significantly more frequent among IVF-conceived children (7.2 cases per 1000 births), who also presented worse indicators of perinatal health; curiously, perinatal health of IVF multiples was comparable to that of naturally conceived multiples (Klemetti et al., 2006 "
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