Isolation and characterisation of impurities in adapalene

ArticleinJournal of Pharmaceutical and Biomedical Analysis 43(3):1161-3 · March 2007with36 Reads
Impact Factor: 2.98 · DOI: 10.1016/j.jpba.2006.09.035 · Source: PubMed


    Three impurities of structure 2-4 were isolated and characterised during the optimisation of a synthetic procedure to adapalene. Impurity 1 was a by-product of the Friedel-Crafts reaction of adamantanol with 4-bromoanisole. Impurities 3 and 4 were due to side reactions of the final Negishi coupling.