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The global economic burden of alcohol: A review and some suggestions

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Economic arguments for acting for health are increasingly important for policymakers, yet to date there has been no consideration of the likely economic burden of alcohol on the global level. A review of existing cost estimates was conducted, with each study disaggregated into different cost areas and the methodology of each element evaluated. The range of figures produced from more robust studies was then applied tentatively on the global level. The reviewed studies suggested a range of estimates of 1.3-3.3% of total health costs, 6.4-14.4% of total public order and safety costs, 0.3 - 1.4 per thousand of GDP for criminal damage costs, 1.0-1.7 per thousand of GDP for drink-driving costs, and 2.7-10.9 per thousand of GDP for work-place costs (absenteeism, unemployment and premature mortality). On a global level, this suggests costs in the range of US dollars 210-665 billion in 2002. These figures cannot be understood without considering simultaneously six key problems: (i) the methods used by each study; (ii) who pays these costs; (iii) the 'economic benefits' of premature deaths; (iv) establishing causality; (v) omitted costs; and (vi) the applicability of developed country estimates to developing countries. Alcohol exerts a considerable economic burden worldwide, although the exact level of this burden is a matter of debate and further research. Policymakers should consider economic issues alongside evidence of the cost-effectiveness of particular policy options in improving health, such as in the WHO's CHOICE project.
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This is a post-peer-review, pre-copy edited version of an article published in Drug and
Alcohol Review. The definitive publisher-authenticated version of
The global economic burden of alcohol: a review and some suggestions
(Baumberg 2006). Drug and Alcohol Review, 25(6):537-552.
is available online at
http://informahealthcare.com/doi/abs/10.1080/09595230600944479
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The global economic burden of alcohol: a review and some
suggestions
Ben Baumberg
1
1
Institute of Alcohol Studies, London, UK
Abstract
Background: economic arguments for acting for health are increasingly important for
policymakers, yet to date there has been no consideration of the likely economic burden
of alcohol on the global level. Method: a review of existing cost estimates was
conducted, with each study disaggregated into different cost areas and the methodology
of each element evaluated. The range of figures produced from more robust studies was
then tentatively applied on the global level. Results: the reviewed studies suggested a
range of estimates of 1.3-3.3% of total health costs, 6.4-14.4% of total public order and
safety costs, 0.3-1.4 ‰ of GDP for criminal damage costs, 1.0-1.7 ‰ of GDP for drink-
driving costs, and 2.7-10.9 ‰ of GDP for workplace costs (absenteeism, unemployment
and premature mortality). On a global level, this suggests costs in the range of $210-
$665bn in 2002. Discussion: these figures cannot be understood without simultaneously
considering six key problems: (i) the methods used by each study; (ii) who pays these
costs; (iii) the ‘economic benefits’ of premature deaths; (iv) establishing causality; (v)
omitted costs; and (vi) the applicability of developed country estimates to developing
countries. Conclusion: alcohol exerts a considerable economic burden worldwide,
although the exact level of this burden is a matter of debate and further research.
Policymakers should consider economic issues alongside evidence of the cost-
effectiveness of particular policy options in improving health, such as in the WHO’s
CHOICE project.
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Introduction
However much those working in the public health field may prefer otherwise, the
importance of ‘economic’ arguments
1
when trying to persuade policymakers to act for
health cannot be understated. As Markos Kyprianou, the Commissioner for Health and
Social Protection in the European Commission, has recently put it, “this evidence
provides a powerful argument for European governments to invest in the health of their
populations, not only because better health is a desirable objective in its own right, but
also because it is an important determinant of economic growth and competitiveness”
(1:5).
This is no less true in the alcohol field than in any other field of public health. The recent
resolution on alcohol in the World Health Assembly noted that WHO members are
“concerned about the economic loss to society resulting from harmful alcohol
consumption” (WHA 58.26). Single figure estimates are also useful for comparing the
size of different health issues, often tobacco, alcohol and illicit drugs (2), and are a
platform on which to build economic analyses of particular policy options (see Chisholm
et al, this issue). Finally, the data demands in these analyses acts as a spur to filling gaps
in the evidence base (3), in particular for the costs omitted in cost-effectiveness analyses
(a point to which we will return in the conclusion).
Unsurprisingly then, there are numerous social cost estimates for different social issues at
the European level (4-6). Amongst these are a series of estimates of the social cost of
alcohol in Europe, originally within the European Alcohol Action Plan 2000-5 (see also
7), but also two increasingly sophisticated aggregate level estimates (8, 9), culminating in
a WHO decision to initiate a detailed study of the social cost of alcohol in each of the
countries of Europe.
1
‘Economic’ is here narrowly defined as arguments involving the money economy, rather than the broader
sense that encompasses changes in Quality of Life (which is therefore much closer to a public health
approach); this point is developed below in footnote 21.
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However, to date there have been no estimates of the likely economic burden at the
global level. This paper attempts to fill this gap by using a review of existing social cost
studies – conducted for the most recent European estimate – to tentatively outline the
international economic burden due to alcohol. As well bringing previous reviews up-to-
date, this review also disaggregates existing studies to look at individual cost areas,
which gives a much clearer picture of how estimates compare to each other.
At the same time, though, the review also highlights the assumptions on which these
estimates are based, many of which appear both problematic in themselves and are
misinterpreted by policymakers in practice. Furthermore, virtually all of these studies
have been conducted within developed countries, and neither the exact estimates nor the
assumptions within them may be appropriate in developing countries. The paper
therefore goes on to critically review the estimates of economic burden, focusing on five
key problems that need to be addressed. The paper concludes with some suggestions as
to the likely size of the global economic burden due to alcohol, and finally places these
estimates within the wider context of economic evaluations.
Methods
2
Theoretical background
The point of departure for nearly all social cost studies is an unreal ‘what if?’ question –
‘what if alcohol disappeared from the world today?’ Behind this unreal scenario lies an
even bigger assumption – that in this hypothetical world, all of the spending and time
spent drinking alcohol is redirected to something that does not burden society in any way.
Thankfully the utility of these studies does not depend upon the plausibility of this
situation, with this imaginative thinking instead being a way of creating a summary
measure of how much (and in what areas) alcohol burdens human society materially.
2
A number of methodological considerations are not discussed here for both readability and space.
However, readers with unanswered questions should refer to Anderson and Baumberg (2006) or contact the
present author.
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Social cost studies also involve a number of other assumptions, some shared between all
studies and others varying between them, of which it is beyond the scope of this article to
cover in full.
3
It is however worth being aware that these studies generally estimate the
economic burden of all past and current drinking on a particular year (prevalence-based),
rather than the burden of new alcohol-related problems on all future years (incidence-
based).
The review also divides between ‘tangible’ and ‘intangible’ costs (see Table 1).
‘Tangible’ costs are those costs that are already in monetary form, such as spending on
healthcare (direct costs), or production losses (indirect costs). ‘Intangible’ costs are those
that do not exist in a monetary form, such as pain, suffering or loss of life itself. The
question of whether intangible costs count as an ‘economic cost’ is discussed below in
footnote 21, and their importance for understanding economic contributions to alcohol
policy is discussed in the conclusion.
Finding and selecting source studies
This paper is based on a review of costing studies undertaken since 1990 (earlier studies
are generally weaker and have been reviewed elsewhere (10)). An initial list of studies
was obtained from PubMed, ETOH and the Web of Science, checked against the WHO’s
Global Status Report on Alcohol 2004 (11) and a search of the Internet through
google.com.
4
These were supplemented by studies from four previous reviews (10),(12-
14) as well as those provided by the European Alcohol Policy Network (APN;
www.eurocare.org/btg/).
5
These studies were selected if they included a new estimate of
the social cost in at least one cost area (the full list of studies included is shown in Table
3
Interested readers can also find further discussion elsewhere (56).(17, 28, 106)
4
The following search terms were used: alcohol*, combined with economic*, cost*, or burden*.
5
Data in languages other than English, French, German or Spanish were translated by the relevant APN
member, using a standard form to extract relevant information only. In two cases the studies were not
publicly available; for transparency purposes, the English summaries have been made available on the APN
website.
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1). Due to data limitations, it was not possible to include studies for either West
Germany (e.g. 15) or sub-national regions (13, 16).
Method of analysis
To overcome problems of methodological inconsistency and coverage of different cost
areas, each study was divided into separate cost areas.
6
For each one, costs were then
expressed as the percentage of an appropriate common metric (or GDP if none were
available) – healthcare costs, for example, were expressed as a percentage of total
healthcare expenditure. The methods used in different studies were also compared using
a checklist of methods and transparency, based as far as possible on the WHO Guidelines
for Estimating the Costs of Substance Abuse (17) and shown in Tables 2-5.
[Tables 2-7 from about here]
Results
The results of the review are shown in Tables 2-7. Each table presents the results for a
particular cost area, expressed as a share of a common metric (‘total health costs’ for
health, ‘total public and order and safety costs’ for crime, but GDP in all other cases).
The tables also include additional information on the method used by the authors in
producing the estimate, with studies meeting all of these criteria shown in bold. This
review is therefore ‘systematic’ in the sense that it examines a common set of
methodological criteria within each cost area – but it is also ‘opportunistic’ in the choice
of these criteria, which are only partially based on good practice guidelines (e.g. 17) and
partially based on the limited extent of the information given in the studies.
It should be noted that there is still substantial methodological variation between studies
that appear similar in the tables, to the extent that it is impossible to attribute variations in
6
All transfers between individuals – whether deliberate or stolen – were also removed (17, 107), as have
the health costs of violent crime (due to the risk of double-counting (28)) and non-market costs such as
household work (as these cannot strictly be compared to GDP (17)).
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costs to genuine differences in levels of harm. For example, differences in health costs
may reflect the use of different estimates of relative risk for the same condition, while
differences in premature mortality costs may reflect the use of different assumptions as to
future productivity increases (even the linked studies from Canada use assumptions on
productivity growth that differ by 2%).
A global estimate
While the figures presented in Tables 1-7 are interesting for the purposes of comparison,
the easiest way to comprehend what these figures mean is to apply them globally, based
on the common metric used in the review.
7
Clearly this will be a tentative estimate
subject to several qualifications, which are covered in detail in the discussion section of
this paper. Nevertheless, presenting these implied figures from the review gives a first
crude indication of the likely global economic burden of alcohol, representing both
information in itself for policymakers and a platform for future work.
The most sensible basis for a global estimate is to restrict the estimates to results from the
best studies, i.e. those highlighted in bold in Tables 2-7. If these are applied on a global
basis, then we can estimate that the global economic burden of alcohol is between
$210bn and $650bn in 2002.
8
This is made up of $40-105bn for health, $55-210bn for
premature mortality, $30-65bn for absenteeism, $0-80bn for unemployment, $30-85bn
for criminal justice systems (police, prisons, courts) and $15-50bn for criminal damage.
This is equivalent to 0.6-2.0% of global GDP (for the countries included) – or more
simply, somewhere between the total GDP of Austria and India.
One small refinement can be made to these extremely crude figures, by using the existing
estimates of the global health burden caused by alcohol (see Rehm, this volume). If we
7
Crime costs are expressed as a % of GDP given the lack of available data on ‘public order and safety’
expenditure as presented in Table 6.
8
GDP figures taken from the UN Statistical Division 1/2/2006; health spending as % of GDP figures taken
from the World Health Report 2005, published by the WHO. All figures are stated to the nearest $5bn to
avoid giving a misleading imprecision of precision.
Page 8 of 38
adjust for the difference in health burden between the countries where cost studies have
been conducted (all very low child and adult mortality) and other countries worldwide,
then the estimate for the global burden of alcohol on health costs becomes $50-120bn
(compared to $40-105bn for the initial method above). The WHO figures further
suggest that developed countries may have a slightly higher share of homicides and road
traffic deaths due to alcohol than elsewhere.
9
Discussion
While this review allows a tentative first estimate of the global economic burden of
alcohol, it cannot be understood without considering six further points that are discussed
below in turn: (i) the methods used by each study; (ii) who pays these costs; (iii) the
‘economic benefits’ of premature deaths; (iv) establishing causality; (v) omitted costs;
and (vi) the applicability of developed-country estimates to developing countries.
The methods used by each study
The present estimate is a distinct improvement on previous review-based estimates (7, 8)
as it accounts for the different cost types included in different studies, and examines how
robust the methods are within each cost type and within each study. Nevertheless, there
are substantial outstanding concerns as to the accuracy of individual studies, as data
limitations are often only surmountable through extrapolations from other data sources
(for example, assuming that the alcohol-attributable share of outpatient health costs is
equal to that of inpatient health costs). Epidemiological data may be similarly
extrapolated from one country to another and from mortality to morbidity. Such
extrapolations may be an inevitability in social cost studies given their onerous data
demands, but it does mean that no estimate can be seen to be precise.
9
For homicide: 31 (developed countries) vs. 32% (developing) of deaths for males and 31% vs. 22% for
females. For road traffic accidents: 41% of deaths in men aged 15-29 compared to 30% in other regions.
‘Developed countries’ defined as countries with very low child and adult mortality; ‘developing countries’
refers to all other countries. Average figures are obtained by scaling the reported alcohol-attributable
fraction for homicide (Rehm et al 2004) by the numbers of homicides in each region (see
http://www.who.int/healthinfo/bod/en/index.html)
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A more theoretical concern is that the review can only follow the data and assumptions
used by primary researchers, the most contentious of which relates to the method of
placing a value on premature death. Studies most commonly assume full employment,
where prematurely deceased workers are not replaced by those who are unemployed.
However, even by the late-1990s it had been widely noted that this could lead to a large
over-estimation of costs, and alternative methods were being recommended (18).
The most common of these – known as the ‘friction cost’ method – has been to assume
that workers who die are replaced at work by a previously unemployed person (19),
which produces a much lower cost of alcohol to society (20, 21). This in turn has been
critiqued for being over-sensitive to macroeconomic variables that are difficult to predict
(22), and more importantly for making unwarranted assumptions that lead to the friction
cost method being an underestimate (see 23, 24). For example, the ‘friction cost’
generally misses the cost of people who cannot be replaced by currently unemployed
people and the likely chains of vacancies that arise by replacing workers with people
employed elsewhere, as well as the cost of training up new workers (23, 25). In practice,
then, the ‘true cost’ is likely to lie between the two estimates – but it is difficult to be
more precise as to exactly where the cost lies.
Who pays these costs?
Perhaps more important than the level of costs per se is whether it is drinkers, other
individuals, government or businesses that pay them. Politicians often see external costs
those that the drinker imposes on other people, such as taxpayer-funded healthcare
costs in the UK – as a reason to intervene in markets, as people do not (often) take these
into account themselves. On the other hand, private costs – those that are paid by the
drinker or their family, such as private healthcare in the US – may be seen as a matter of
individual choice, given that rational individuals only do something if the (private) gains
are more than the (private) costs (26).
As well as this basic division of costs, there are situations that are ‘private’ in a simple
view but may nevertheless be persuasive in justifying government regulation. One of
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these is harm within the household (e.g. child neglect), which is treated as private in
mainstream economics but often seen as requiring intervention in wider society. Indeed,
it seems clear that due to alcohol-related harm within the family, the proper unit of
analysis should be the individual rather than the household.
Another politically important situation is where people cannot make rational decisions,
such as where they are addicted, or if they do not have good information on the costs and
benefits of how much they drink (17, 27). Some researchers have argued that private
decisions made in these conditions should also be included in the total social cost figure –
typically by putting a certain share of total consumption as ‘abusive’ (28, 29). Clearly
this decision adds substantial amounts to the total figure – the total estimated social cost
of alcohol in the EU of €125bn (9) compares to €125bn spent on beer alone in the EU
(30), which using the assumptions of Collins and Lapsley in Australia
10
would imply an
additional cost of €25bn. One consequence of including these costs, however, is that a
poor information campaign – which would increase knowledge of the risks of alcohol
without changing behaviour – would substantially reduce costs without affecting harm,
which would seem to be a slightly counterproductive result of an ineffective policy.
Studies that look only at external costs are rare, and are generally adjustments to existing
major social cost estimates (31-33). These suffer from the exclusion of ‘transfer costs’ in
most studies – where money is moved from one group to another (e.g. from government
to the unemployed), rather than being lost – which are likely to be significant in external
cost studies. The most revealing study that looks at who pays the costs comes from
Australia (28), where the highest costs for business and government were workforce
labour, road accidents and crime.
11
Together these accounted for nearly two-thirds of the
total cost, even after considering the enormous private cost of ‘resources used in abusive
10
This assumption is that 20% of all alcohol consumed was drunk by addicted drinkers and should
therefore be included in the social cost. This excludes the cost of drinking when the drinker does not have
complete information on the risks of alcohol.
11
It should be noted that health costs in the Collins and Lapsley studies are relatively low compared to
other studies as they take into account the ‘savings’ of premature deaths; see below.
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consumption’. Other research also suggests that only around one-half of those injured in
these accidents are the drink-drivers themselves (9), which means that much of the cost is
borne by the ‘innocent victims’ of these accidents.
The ‘economic benefits’ of premature deaths
One of the stranger aspects of social cost studies is that they tend to look at present costs
without looking at future savings. For example, in a world without alcohol, a person
dying of alcohol-attributable liver cirrhosis at age 50 may otherwise have contracted
Alzheimer’s disease at age 80. This may partly explain the inconsistent and otherwise
puzzling finding (34) that healthcare costs for abstainers and heavy drinkers are both
much higher than for lighter drinkers (e.g. 35), although this may also reflect
methodological weaknesses (36) and relatively short follow-ups.
12
.
The ‘real’ health burden therefore depends on whether alcohol-related disease is cheaper
to treat than all the diseases that people would otherwise have got in an alcohol-free
world. This means that there is a lower social cost of conditions that kill people quickly,
as opposed to conditions that lead to long periods of illness requiring expensive treatment
(37). In the one study that has investigated this for alcohol, an overall healthcare cost
was found, but this was a much lower value than found in the conventional
methodology.
13
Does this mean that conventional health cost estimates should be discarded as
meaningless? I would argue that this would be an overreaction, for two reasons. Firstly,
12
More theoretically though, there are two reasons why we may not expect individual-level studies to
match the social cost results. Firstly, there may well be systematic biases in how individuals react to
healthcare, with some research suggesting that relatively heavy drinkers may have shorter stays in hospital
as they cannot carry on with their drinking (36). Such biases are particularly important for outpatient
service use, where variations in care-seeking behaviour are likely to explain at least part of the negative
relationship between alcohol use and outpatient service utilization (see summary in 35).
13
Ironically, Collins and Lapsley also found that the health benefits of alcohol increase the total healthcare
burden. This is presumably because cardiovascular disease leads to death relatively more than long-term
disability, and so preventing cardiovascular disease leads to an increase in health costs.
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cost studies for all social issues use the same methodology, so that any change must be
made across the board rather than in a single study. Secondly, these estimates are still
meaningful, in that it is accurate to say that an estimated $50-120bn was spent treating
conditions caused by alcohol in 2002. It is unarguable, however, that the figures should
be presented clearly to avoid the all-too-common misunderstandings among
policymakers.
It should finally be noted that a parallel finding can be found for the productivity cost of
premature death, if we take into account the resources that people would otherwise have
used up if they had stayed alive (e.g. pensions). Two studies have estimated this for
alcohol, in both cases finding that it reduced the cost of premature mortality by about
30% (28, 38). However, the implication of these analyses is that an individual’s
expected production is less than their expected consumption from the age of 55 (39),
which is politically troubling, and whose implications are discussed in more detail in the
conclusion.
Establishing causality
The difficulty in dividing between what is due to alcohol from what is merely associated
with it is a common one in research on alcohol, and there is clearly insufficient space to
discuss the issue fully in this paper (for an introduction, see the brief review in 40). It is
nevertheless essential to consider the issue of causality in social cost studies, if only
because it is often brushed over in both the studies themselves and previous reviews.
The most illuminating way of showing these points briefly is to look at a single case
study, that of lowered productivity.
While there is agreement between drinkers (41) and employers (42) that drinking can
lead to lowered productivity at the workplace, there are substantial difficulties in valuing
this precisely. Most of the existing effort has been made by economists looking at the
issue of wages and alcohol, based on the assumption that – in a perfect labour market –
lower productivity or attendance due to alcohol will result in lower wages. Such
assumptions underlie estimates in several countries (e.g. 21, 43, 44), although several of
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these (45) simply imported a US estimate (46) into their own country due to a lack of
other data.
14
Yet while this US study looked at the wage penalty in people who have
suffered from alcohol dependence, nearly all studies also show that light drinkers have
higher wages than abstainers (Russia in 47, the US in 48, Australia in 49, the Netherlands
in 50).
The key question here, then, is whether these results show ‘genuine’ costs and benefits of
alcohol, or simply reflect systematic biases in the methods used (51 p360).
Firstly, income could influence alcohol consumption, in that people with more money can
buy more alcohol. Some researchers have claimed that looking only at alcohol use
disorders (rather than consumption levels) reduces this bias, because individuals do not
‘choose’ to suffer from these in the same way that they can choose to change how much
they drink (46).
15
Secondly though, and more problematically, both drinking levels and
wages may be jointly influenced by some other factor, such as how much risk someone is
willing to take in their decisions. There has been a tendency to ignore this problem,
however, presumably because the spurious relationship will be in the ‘right’ direction and
therefore allow a cost burden to be estimated.
These problems are relatively common in economic analyses, and economists have
developed complex tools to deal with them.
16
Yet the unavoidable conclusion from this
14
Even this US evidence is not altogether convincing – a wage penalty was only found for men who had
ever suffered from alcohol dependence (but not alcohol abuse, and not for women at all). The estimate also
assumes that education is a mechanism through which ever-being alcohol dependent can affect wages (i.e.
it uses a reduced-form model). Harwood et al justify this using research that suggests those reporting
youthful alcohol abuse have less education than would be expected from their background, although more
recent research contradicts this (108). If this assumption is dropped, then Harwood et al find no significant
effect in any group.
15
Although the risk of suffering from an alcohol abuse disorder increases at higher levels (and more
detrimental patterns) of consumption, there are more intervening variables (such as genetic vulnerability)
that create a more uncertain probability than found for the level of consumption.
16
Many studies use called an ‘instrumental variables’ technique by looking at the association between
wages and variables that are correlated with alcohol use but not with wages (e.g. alcohol tax changes).
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research is that these tools are simply not good enough to produce unbiased estimates of
the effect of alcohol. For a start, the estimates from this method are often implausibly
large (50), to the extent that the National Bureau of Economic Research concluded that
“it is unlikely that previous studies…have produced credible estimates of the effect of
alcohol use on labor market outcomes” (51:370). A more recent study documents these
flaws even more convincingly by looking at the same people over several years, thereby
controlling for all the differences between drinkers and non-drinkers that do not change
over time (52). This found no significant effect of alcohol use at the 5% level on wages
in either men or women, for any level of consumption or for binge-drinking.
Does this mean that there is no relationship between alcohol use and productivity or
absenteeism (51)?
17
While some researchers would seemingly answer yes (53), it is
unclear on further reflection why anyone ever expected wages to have a ‘genuine’
relationship with levels of alcohol use. At a basic level, worker productivity may not be
easily visible to an employer, and even if it is visible then wages may take some time to
reflect changes in productivity (21). More importantly, in a workplace culture where
drinking is accepted, there may even be a workplace penalty where drinking is expected,
such as for the cantineras in Texas who see drinking as a workplace duty (54). Non-
drinking could equally damage prospects where intra- and inter-firm networking is based
on socialising over drinks, as suggested by the £250 per employee spent on alcohol by
UK advertising firms (55).
This case study provides two lessons for future research. Researchers should be careful
in using a proxy variable instead of the measure they are actually interesting in, but more
importantly, the ever-present risk of spurious relationships requires imagination in
research design rather analysis – a point that echoes a call made 15 years ago (27, 56).
Other than better use of natural experiments, an interesting example is a small US study
that looked at the same individuals over four weeks, and found that the relative risk of
17
Similar results have also been found for drinking and unemployment, in that alcohol use disorders are
associated with higher unemployment, light alcohol consumption is sometimes associated with lower
unemployment, and complex methods often produce implausible results (51).
Page 15 of 38
being absent was 10-times greater for individuals on the day after drinking. Although
this study had other methodological weaknesses,
18
it demonstrates how creative
approaches can produce more persuasive results than more expensive and sophisticated
number-crunching.
Omitted costs
Alcohol touches upon many areas of human life, and few studies can claim to covert
these comprehensively. This may be unimportant, however, if the omitted costs are
merely those that are likely to be relatively insignificant. For example, the cost of fires
that occur because people are drunk is only 1% of the total cost in all of the four countries
where this has been estimated (21, 45, 46, 57). It is therefore unfortunate that many of
the frequently omitted cost areas fall into the groups of either ‘miscellaneous productivity
costs’ or ‘other crime costs’, which are both likely to be responsible for a substantial
burden.
‘Miscellaneous productivity losses’ includes many areas where the effect of alcohol is
costed but the impact on people’s ability to work is ignored. For example, the labour loss
due to all workplace accidents accounts for most of the estimated €55bn total cost for the
EU15 (6). Other parallel areas include lost working time from travel delays due to drink-
driving accidents (58, 59), and from people imprisoned due to alcohol-attributable crime
(28, 46, 57) as well as their victims (42, 60). More fundamentally, traditional methods
systematically miss out the work done by people outside the labour force, such as caring,
housework and voluntary work (see Table 3). More recent studies find ways of giving a
value to this work, generally finding that it significantly adds to the total burden of
alcohol (21, 38, 46, 61).
18
For example, alcohol consumption was reported retrospectively at two-week intervals, and the study did
not ask about the quantity of alcohol consumed (or any other features) of the drinking occasion. Such
weaknesses were enough for a systematic review to classify the study as of ‘low quality’, although it should
be noted that only one study worldwide met their definition of even ‘medium quality’ (109).
Page 16 of 38
Most of the crime costs’ considered above concentrate only on the cost of crime in terms
of the criminal justice system, and occasionally also look at the value of criminal damage.
However, the study from the UK Prime Minister’s Strategy Unit was able to build upon
an existing estimate of the ‘cost of crime’ to look at the money spent by private citizens
and companies on preventing crime in advance (burglar alarms, security guards). This
added up to a burden that was equivalent to the total value of criminal damage and only
slightly lower than the cost of police, courts and prisons, demonstrating that the omission
of these costs leads to a serious underestimate of the cost of alcohol-attributable crime
(42).
19
From a global perspective, though, perhaps the most worrying omission is one that has
never been included in a social cost study – the burden of sexually transmitted diseases
(STDs), particularly the enormous burden of HIV/AIDS (62). Certainly there is almost
universal evidence that alcohol is associated with risky sex (e.g. unprotected sex, multiple
sex worker partners) (e.g. 63, 64), which is in turn a risk factor for STDs (65-69). As
discussed at length above, though, the difficulty lies in teasing out the causal link from a
multitude of simple associational data. On the one hand, there are clear theoretical
reasons for seeing this link as ‘genuine’, given the pathways through which drinkers
themselves suggest alcohol genuinely affects sexual risk taking, including reduced
inhibitions and providing a socially acceptable excuse for not using condoms (70, 71).
This is bolstered by experimental evidence that shows how judgement and risk-taking are
affected by drinking in a laboratory setting (72).
On the other hand, there has been a greater problem in demonstrating a link between
risky drinking and actual STD outcomes. A recent systematic review looking at STDs
(but excluding HIV/AIDS) found that there are substantial problems in saying
confidently that there is a causal role of problem drinking (73). Studies looking at the
dose-response relationship have found inconsistent results, and insufficient effort has
19
The same study also valued stolen property as a cost to society, but this has been removed from the
current comparison as it was felt to count as a ‘transfer’ rather than a ‘loss’.
Page 17 of 38
been given to ruling out alternative explanations of an association. Moreover – and
despite the claims of Cook and Clark – the association between problem drinking and
STDs in these studies is simply inconsistent.
20
In contrast, though, a recent National
Bureau of Economic Research paper found that higher alcohol taxes were associated with
lower gonorrhoea rates among young adults in the US, although the results for HIV rates
are less clear (74).
Overall, the implication for future economic studies is that more attention should be paid
to STDs, particularly where the economic burden of HIV/AIDS is high. Despite the need
for further research, there is at least as much evidence for a relationship between STDs
and alcohol use as there is for lowered productivity at the workplace, and the NIAAA in
the US has concluded that “decreasing alcohol use in people who have HIV or who are
at risk for becoming infected reduces the spread of HIV and the diseases associated with
it” (75). Even if the causal relationship is much less than the associational one – such as
for condom use, where a recent meta-analysis suggested that drinking may only be
important for condom use at first intercourse (76) – this may still lead to a considerable
cost, especially considering the effect this may have on long-term equilibrium points.
Are the costs applicable in developing countries?
Perhaps the most difficult question to answer is whether the costs identified in the
countries in Table 1 will be equally applicable in developing countries, as persuasive
cases can be made for both higher and lower costs being likely. Lower costs may arise
due to limited Government spending on e.g. health systems or crime, or a greater number
of potentially employable people to replace those dying or becoming unemployed due to
the effects of alcohol. It can also be argued that “where the God of Productivity has few
20
Cook and Clark argue that “problem drinking is clearly associated with an increased risk of STDs” (73
p159), given that 8 of 11 studies found a significantly increased risk of at least 1 STD among problem
drinkers compared to non-drinkers. However, this conceals the fact that many studies performed multiple
tests separately (e.g. for men and women, for different measure of alcohol use, or for different STDs) – if
we instead look across the full 22 contrasts among problem drinkers, we find that over half were non-
significant, and that 2 further contrasts were insignificant in multivariate analyses.
Page 18 of 38
followers, the negative impact of alcohol on production will not be perceived as a
problem” (77 p103).
Conversely, additional burdens on health systems in developing countries may not be
able to be absorbed in increased spending, and may instead lead to otherwise preventable
deaths. In parallel, individuals with key skills may be effectively irreplaceable in the
workforce, leading to much more economic damage than in richer countries (78).
Workplace-related accidents are also likely to be more common in developing countries
where ‘the extrusion of drinking from the workplace’ (79) is yet to occur, and a variety of
harms may be more likely in the absence of a well-developed treatment system for
alcohol dependents (assuming such treatment is cost-effective). Finally, and as suggested
by the health cost estimate above, the burden of alcohol on human health is greater in
developing countries. Coming down definitively on either side of this argument is
impossible given the current research base, as it is likely that the net effect involves a
balancing of these factors against each other.
There is, however, a further burden that should be considered, although it could never be
included as a ‘social cost’ in the conventional sense – ‘reduced economic development’
(as the World Health Assembly resolution phrased it). Money spent on alcohol can lead
to household impoverishment (80, 81) and the diversion of money away from investment
in economic development (82); it has also been suggested that the move to more
expensive and often international beverages may lead to worsening nutrition in women
and children (83). Clearly there are also development benefits from increasing and
internationalizing alcohol consumption – for example, in employment, government tax
revenues, and technology transfer (84). Yet these can be overstated (78, 85), especially
considering that modernization of brewing and distilling may lead to a reduction in the
number of jobs as productivity increased. And clearly, the economic burdens discussed
throughout this paper must also be taken into account.
Conclusions
Page 19 of 38
Having presented a review and some tentative estimates of the global economic burden
due to alcohol, followed by a discussion of the problems in such studies, there remains
three final points to be made in this conclusion. The first is to draw attention to the limits
of any discussion on the economic burden so-defined, which can only ever quantify a
fraction of the true ‘cost’ of alcohol-related harm. This becomes especially clear when
looking at the ‘cost savings’ from people who die prematurely, which has resulted in a
claim by Philip Morris that tobacco deaths in the Czech Republic save the country money
(86). Such a morally disastrous conclusion can be avoided by putting a value on pain,
suffering and human life itself, although the exact value of these ‘intangible costs’ will
always be contentious. Even so, the various values that have been placed on healthy
human life suggest that these intangible costs are between one- and seven-times the value
of the ‘real money’ costs in the EU (see 9). In other words, there is more to health than
economic arguments alone.
21
Second, few of these studies have evaluated the benefits of alcohol. We can get an idea
of the likely size of these for health costs, using a study in Switzerland that explicitly
compared different methods and alternative scenarios (38). This showed that the health
costs were about 30% lower if health benefits are taken into account relative to a situation
of no consumption – but that the net costs relative to light drinking were only 11% lower
than the gross costs relative to no drinking at all (a much more sensible definition of ‘the
full net social cost’). No studies have quantified other social benefits of alcohol (see 9),
although it should be noted that the size of the alcoholic drinks industry is not an estimate
21
As an aside, it should be noted that ‘health economics’ as a discipline deals substantially with matters
other than production losses, such as Quality of Life and leisure time. The difference between public health
and economic approaches is therefore merely a matter of whether money is used as a metric that enables
otherwise incommensurate areas (work impairment, premature mortality et al) to be combined in analyses.
However, ‘economics’ in popular and policy usage tends to refer to the narrower set of concerns that have
here been labelled ‘economic arguments’ in this article, as seen in e.g. the economic impact assessment for
the prospective European Commission Communication on alcohol (RAND Europe, to be published later in
2006). Many thanks to an anonymous reviewer for stressing the need to clarify this point.
Page 20 of 38
of the social benefit of alcohol, as many of the resources employed in making and selling
these drinks would be used for other purposes (17, 42, 87).
Finally, the main thrust of this article has been to show that alcohol exerts a substantial
economic burden, and that this burden is likely to apply (to some extent) across the
world. This in itself is an important adjunct to the ongoing global debate about acting on
alcohol, although it must clearly take a ‘back seat’ compared to health and welfare
justifications for reducing alcohol-related harm. Yet it can only be a first step in
economic contributions to policymaking, as further research should quantify the share of
costs that can be avoided, the policy investments that should be made to avoid them, and
should then monitor how effective the policies have been in reducing costs (88). In this
vein, the WHO’s CHOICE project (see Chisholm et al, this volume) is an important aid
for policymakers – yet this paper also clearly understates the case for acting on alcohol,
given that it looks only at health outcomes rather than the full burden outlined here.
Further analyses should therefore work towards an elusive goal: a comparative analysis
of the full costs and benefits of different policies that work to reduce the harm done by
psychoactive substances.
Acknowledgements
Many thanks to Christine Godfrey for helpful comments at various stages of the work,
and to Peter Anderson for support during the Alcohol in Europe project (which provided
the foundation for the work in this paper). Thanks also to the anonymous reviewer for
helpful comments for this final version of the paper.
Conflict of interest
I declare that I have no conflict of interest relating to the material presented in this paper.
Page 21 of 38
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Page 31 of 38
Page 32 of 38
Table 1 – Overall comparison of social cost studies included in the review
Year of Cost
Total tangible
costs
Total cost per
capita (inc.
intangibles)
Year of Cost
Total tangible
costs
Total cost per
capita (inc.
intangibles)
% of
GDP
PP € 2003
% of
GDP
PP € 2003
Australia (28, 89) 1998/9 0.9–1.0 286–315 * N’lands
(90) 1996 0.3 78
* Belgium (91) 1999 2.4 586 New Zealand (29) 1990 4.7 4289
Canada (2) 1992 0.9–1.3 195–265 New Zealand (92) 1991 1.4–2.4 234–386
Canada (21) 2002 0.7–1.7 180-451
New Zealand(59) 1996 - -
Denmark 1996 0.9 218 Norway (93) 2001 1.2–2.1 447–729
Eng. & Wales (42) 2001 1.5–1.7 456–497 Portugal (43) 1995 0.5 73
Finland (57) 1990 1.3–1.8 482–823 Scotland (94) 2001/
2
0.7 296–360
France (95, 96) 1997 1.2–1.4 256–300 Slovak R. (97) 1994 3.1 292
France (98)
1996 - - Slovenia (99) 2002 0.3 50
Germany (61) 1995 1.1 253 Spain (100) 1998 0.7 129
Ireland (101) 2003 1.6 447 Sweden (102) 1998 5.5 1,194
Italy (103) 1994 0.7–0.8 134–153 Switzerland (38) 1998 0.5–0.7 435–482
Japan (44) 1993 1.9 381 USA (46, 104) 1992 2.3 666–731
Latvia (105) 1999 1.8 113 USA (60) 1985 1.7 447
N’lands (45)
2000 0.7 171
USA (58) 1995 - -
Figures may differ from reported headline figures as ranges may be taken from sensitivity analyse; * =
Industry-funded study;
† =
Total cost is inflated to 2003 prices and adjusted for purchasing power;
=
DUI costs only
Page 33 of 38
Table 2 – Review of health costs (selection of most methodologically sound studies)
Cost
% of total
health spend
Accidents,
homicide
& suicide
1
AAF
method
2
Treatment
separate
3
Canada (2)
1.3–1.6 Y Y Y
Canada (21)
2.3 Y Y Y
Denmark
3.4 Y
England &Wales (27)
2.8–3.3 Y Y Y
Finland (29)
0.9–1.4 Y Y
France (31, 32)
2.4 Y
Germany (36)
2.3 Y Y Y
Italy (40)
1.7–1.9 Y
Japan (42)
4.9
Latvia (105)
Y
Netherlands (46)
0.3 Y
* Netherlands (21)
0.7 Y
New Zealand (24)
1.3 Y Y
Norway (26)
0.7–1.3 Y Y
Portugal (28)
0.5 Y
Scotland (30)
1.4 Y Y
Spain (37)
2.4 Y
Switzerland (41)
1.4 Y Y Y
USA (4, 43)
1.5 Y Y Y
1
Indicates whether studies included accidents, homicide and suicide (studies omitting these will produce
noticeably lower results).
2
‘AAF method’ = use of the Alcohol Attributable Fraction (AAF) method (17), where international
epidemiological evidence on relative risk is combined with national surveys on prevalence. Those studies
not using this method either restrict themselves to conditions defined as attributable to alcohol, or are little
more than ‘guesstimates’.
3
‘Treatment separate’ indicates whether the study values specialist addiction treatment separately to the
main figure. Often it is unclear whether these costs are incorporated within the headline health cost, or
whether there was insufficient data to evaluate these.
Page 34 of 38
Table 3 – Review of premature mortality costs using the human capital method
Cost ( (per
thousand) of GDP Details of method
Workplace
Non-
workplace
Discount
rate (%)
1
Gross or
net costs
AAF
method
Suicide and
accidents
Canada (2)
2.4-2.6 10 Gross Y Y
3.9 6 Gross Y Y
5.4 4 Gross Y Y
Canada (21)
1.6 5 Gross Y Y
Denmark (20)
1.7 - 3.25 Gross Y Y
England & Wales
(Leontaridi}
2.6-2.8 - 3.5* Gross Y Y
Finland (57)
6.5 - 10 Gross Y
10.3 - 4 Gross Y
France (96)
4.4-6.5 - 6 Gross Y Y
Germany (61)
3.7 0.2 2 Gross Y Y
New Zealand (92)
0.3 - 10 Gross Y Y
0.6 - 5 Gross Y Y
Norway (93)
1.6-9.3 - 3.5* Gross Y
Switzerland (38)
1.4 0.8 6 Net Y Y
2.0 1.2 2 Net Y Y
2.6 1.6 0 Net Y Y
US (46)
4.9 6 Gross Y Y
6.3 5 Gross Y Y
7.2 3 Gross Y Y
1
The discount rate is a way of turning future costs into present-day values (as the same amount of money is
more valuable now than in 10 years). The WHO’s Guidelines (17) suggested that all studies should include
estimates using rates of 5% and 10% to aid comparison; only studies with rates of 4-6% are highlighted in
bold to aid comparison.
* Reduced to 3% after 30 years.
Page 35 of 38
Table 4 – Review of absenteeism costs
Cost ( (per
thousand) of
GDP
Method
1
Groups/
conditions
included
Australia
0.1 Hospitalization See discussion of method in
text (demographic model)
England & Wales (27)
1.4
Employee survey
Alcohol dependents
2.0 All drinkers (injury only)
and alcohol dependents
France (31, 32)
0.4-0.5 Hospitalization Excludes accidents and
suicide (see Table 2)
Germany (36)
0.8 Hospitalization & treatment
Long-term absences directly
attributable to alcohol, plus
occupational disability
Italy (40)
1.7-1.8 Hospitalization ‘Alcoholics’ plus all in
alcohol-related accidents
Japan (42)
0.1 Hospitalization & treatment No further detail
New Zealand (92)
0.2 Hospitalization
Assumes alcohol abusers
will be 25% less efficient
than general population
Norway (26)
1.0-1.1 Employee survey No further detail
Slovenia
0.1 Hospitalization No further detail
1
‘Hospitalization’ refers to estimates based on the number of days spent in hospital for alcohol-attributable
conditions as a lower bound for the total alcohol-attributable absenteeism. ‘Employee survey’ refers to
primary research on how levels of absenteeism link to alcohol use disorders in the individual.
Page 36 of 38
Table 5 – Review of unemployment costs (all transparent studies)
Cost ( (per
thousand) of
GDP
Excess
unemployment
in which
group?
Other details
England & Wales (27)
2.0 Alcohol abusers and alcohol
dependents – men only Based on MacDonald and
Shields (2004
2.4 Alcohol abusers and alcohol
dependents – both genders
Netherlands (45)
2.4 ‘Problem drinkers’ Assumes ½ of this is due to
confounding
Norway (93)
0.6 Those suffering from
alcohol use disorders
Based on MacDonald and
Shields (2004)
Scotland (94)
1.3 Alcohol dependents
Uses national data on
employment rates in alcohol
dependents v. others
Switzerland (38)
0.6 Heavy alcohol users (>4
glasses/day f, >6 glass m)
USA (46)
0.0
1
Alcohol abusers and alcohol
dependents
Multivariate regression
analysis
1
Harwood et al did attempt to estimate the effect of alcohol use disorders on unemployment, but found no
influence of any of their alcohol measures on any of their employment measures.
Page 37 of 38
Table 6 – Review of crime costs
Cost (% of total
‘public order &
safety’ spend)
Cost (‰ (per
thousand) of GD
Criminal damage
( (per thousand) of
GDP
Crimes covered
Source data
Control for
causality
1
Australia
8.4-15.9 1.4-2.7 - All Arrestee and
prisoner surveys
Arrestee/prisoner
attributions
Belgium (91)
1.4 0.2 - * * *
Canada (2)
10.5-12.3 1.9-2.3 - Violence and
property offences,
alcohol-defined
crime
? ?
Canada (21)
14.4 2.7 - Arrestee and
prisoner surveys
Arrestee/prisoner
attributions
England &Wales
(27)
10.6 2.1 1.6 All
Victim surveys,
supplemented by
arrestee research
None
Finland (29)
12.7-13.9 1.7-1.9 0.6 All Unclear Unclear
Netherlands (46)
1.4 0.2 0.7 * * *
* Netherlands (21)
3.7 0.2 0.7 * * *
New Zealand (24)
25.0 –
51.6 3.2-6.5 - All Brown (1986) Unclear
Norway (26)
1.9 0.2 - All Unclear None
Scotland (30)
14.4 3.0 - All
Flat rate for all
offences from
arrestee survey
None
USA (60)
9.2 0.9 0.4 Violence and
property offences,
alcohol-defined
crime
Harwood et al
(1984)
Interviews with
prisoners
USA (4, 43)
6.4 1.0 -
Update of
Harwood et al
(1984)
Interviews with
prisoners
* These three estimates are based on a single source (90), which appears to produce implausible estimates
when compared to other research in the Netherlands (see discussion in 9).
1
Some studies reduce the figure of association between alcohol and crime by e.g. asking prisoners whether
they feel they committed a crime because they were drunk (see discussion in 9).
Page 38 of 38
Table 7 – Review of drink-driving costs
1
Cost
( (per
thou) of GDP
Australia
1.2
Belgium
6.2
Canada (2)
0.7
Canada (21)
0.7
Denmark
1.2
France (31, 32)
1.4-2.1
Germany (36)
0.4
Japan (42)
<0.1
Latvia (105)
1.7
New Zealand (59)
1.7
Norway (26)
<0.1
Portugal (28)
0.7
Switzerland (41)
0.3
USA (60)
0.6
USA (58)
1.0
USA (4, 43)
1.2
1
Studies typically referred to other cost estimates for all road-traffic accidents, of which a proportion was
attributed to alcohol. Given that this made detailed methodological comparison problematic, only the two
studies (both conducted by the same lead author) that focused entirely on drink-driving (and are also the
most transparent and sophisticated) are highlighted in bold.
... Alcohol consumption can impair work performance that results in absenteeism (i.e., absence from work) and presenteeism (i.e., reduced work performance) [1]. In 2002, it was estimated that the cost of absenteeism was 30-65 billion USD globally, which was around 10-14% of global economic burden from alcohol [2]. Studies from Sweden and Norway found that a 13% increase in sickness absence from work was associated with 1 L increase in pure alcohol consumed [3,4]. ...
... Most studies on the cost of alcohol-related impaired work performance estimated the cost based solely on absenteeism [1,2,10]. Nevertheless, as mentioned earlier, Sullivan et al. demonstrated that presenteeism accounted for a greater portion of productivity loss of drinking employees. ...
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Introduction Alcohol's harm to others (AHTO) in workplaces has received little attention. A few studies from high‐income countries have estimated the cost of AHTO in workplaces, while data from the low‐ and middle‐income countries are lacking. This study aimed to estimate the cost of AHTO in workplaces and to explore factors associated with the cost of AHTO in workplaces. Methods Data were taken from 1392 employed respondents who participated in a survey conducted in Thailand from September 2012 to March 2013. The cost of extra work hours was estimated from the hourly wage and extra hours of work. The hourly wage was computed by converting monthly income to weekly income and dividing weekly income by weekly working hours. The gamma regression with log link was used to determine factors associated with the cost of extra working hours. Results The past‐year prevalence of harm from co‐workers' drinking was 17.8% among the employed population. The prevalence of working extra hours was 6.1%. On average, an affected worker worked 16.0 extra hours due to co‐workers' drinking. In total, 28.8 million hours of extra work was attributed to co‐workers' drinking in 1 year. The cost of these extra work hours was 1.8 billion Thai baht (57.8 million USD). Age, education and type of employment were associated with the cost of working extra hours. Discussion and Conclusions The burden of alcohol in workplaces extends beyond drinking workers. Our findings indicate that alcohol imposes a significant cost on co‐workers of drinkers.
... There are likely to be large global costs incurred from alcoholrelated productivity losses, however, there are considerable challenges of accurately estimating costs, primarily because of the heterogeneity between methodological approaches and data. 51,52 One review of 12 countries including Europe, Australia, Japan, South Korea, Thailand and the US, indicated 16 of the 22 studies showed productivity loss-related costs represented between 23% and 96% of the total costs incurred, translating to the largest proportion of all costs and in nearly half of the studies this cost accounted for the highest proportion of indirect costs (which include productivity loss, premature mortality and 'other' indirect costs) ( Figure 5.7). 51 For instance, in Japan, this was equivalent to nearly 80% of a l e s C a n a d a T h a i l a n d N e t h e r l a n d s S c o t l a n d G e r m a n y A u s t r a l i a A u s t r a l i a A u s t r a l i a C a n a d a F r a n c e F i n l a n d the total indirect cost and accounted for both absenteeism and presenteeism. ...
... Another review indicated indirect costs were likely to represent between 2.7% and 10.0% of total, global GDP. 52 Table 5.1 provides a summary from a global review of monetary loss associated with lost productivity from alcohol-related illness. 29 This review highlighted that a 25% increase in the US beer tax would prevent 4.6 million workdays lost annually due to workplace injury, equivalent to a reduction of costs from lost productivity of USD 905 million (2020 value). ...
... Occupational therapists are well-versed in the negative consequences of unemployment and will thus recognise the adverse effects on health and wellness [17][18][19][20] . Bartley 21 highlighted the effect that a spell of unemployment can have on subsequent employment patterns. ...
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Background: Not all occupations are undertaken entirely by choice. Numerous personal, cultural, economic and social factors influence participation in occupation. In low and middle-income countries, such as South Africa, disparate socio-economic factors might necessitate participation in occupations considered to be 'less desirable'. In this article the occupation of street vending is explored and discussed, with an emphasis on livelihood creation and the meaning and purpose derived from this occupation. Street vending is considered for its potential as a vocational occupation for people facing disabling conditions. Methods: A collective case study was done comprising six participants who were selected through maximum variation sampling. Data was collected using semi-structured interviews and participant observation. Data analysis took the form of an inductive content analysis. Results: Occupational therapists need a comprehensive understanding of occupations before making judgements about these, especially when such occupations are not considered mainstream. One such occupation, namely street vending, predominates in the informal economy of South Africa. Findings revealed that, despite hardships associated with this occupation, street vendors adapt to social, political and economic challenges in their context. Recommendations: A comprehensive approach is needed when appraising the suitability of occupations; one that focuses on the transformative value of occupations in livelihood creation, rather than focusing narrowly on their therapeutic use or potential to contribute to personal meaning. Occupational therapists should adopt a multi-dimensional approach by considering vocational occupations within their social, cultural and political context, whilst keeping the functional requirement in mind and matching these dimensions with impairment or disability if prevalent. Key words: street vending; livelihood creation; informal economy; occupation; occupational justice
... Alcohol-associated cardiovascular complications [3], a collective term covering a broad spectrum of conditions, represent significant morbidity and mortality on a global scale. Given the substantial burden, the financial impact of alcohol and cardiovascular disease (CVD) on the global healthcare system is substantial [4][5][6]. ...
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Background and Aims: The burden of alcohol-related complications is high and rising. However, there are notable deficiencies in comprehensive epidemiological study focusing on cardiovascular complications from alcohol, especially among young and middle-aged adults. We thus aimed to determine the burden of these conditions in young and middle-aged adults globally. Methods and Results: We used data from the Global Burden of Disease Study 2019 and analysed the mortality and disability-adjusted life years of alcohol-associated cardiovascular complications in young and middle-aged adults. The findings were classified by sex, region, country, and Sociodemographic Index (SDI). The highest age-standardized death rates (ASDR) were observed in stroke 0.84 (95% UI 0.60–1.09), followed by alcoholic cardiomyopathy 0.57 (95% UI 0.47–0.66) per 100,000 population. The overall burden of alcohol-associated cardiovascular complications decreased globally but increased in atrial fibrillation and hypertensive heart disease. Regionally, most regions underwent a decrease in ASDR, but an increase was observed in Southeast Asia (+2.82%), Western Pacific (+1.48%), low-middle (+1.81%), and middle SDI (+0.75%) countries. Nevertheless, the ASDR and ASDALYs were highest in Europe. Conclusions: The impact of alcohol-associated atrial fibrillation and hypertensive heart disease has increased over the last decades. Regarding region, the burden in Europe and the rising burden in Asia, require immediate public health policy to lessen these cardiovascular complications from alcohol in young and middle-aged adults.
... olduğu tahmin edilmektedir (WHO, 2014). Buna alkolle ilişkili sağlık sorunlarına harcanan 40-105 milyar dolar, suç ve şiddet için 30-85 milyar dolar ve işsizlik için yaklaşık 0-80 milyar dolar dahildir (Baumberg, 2006). Günlük 1 ila 1.5 litre alkol tüketiminin yol açtığı sağlık sorunları ve yaralanmalar, her yıl toplam sağlık harcamalarının yaklaşık %2.4'ünü temsil eden tıbbi maliyetlere neden olmaktadır. ...
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... According to WHO alcohol-attributable fractions are responsible for 6.9% of all deaths in Poland. Also, alcohol-related incidents were estimated to be responsible for 1.3-3.3% of total health costs [13]. Moreover, alcohol intake was found to be associated with 52.3% [14] of violence in the emergency room, which is not only a danger to other patients but also may have significant psychological consequences for staff members such as burnout [15]. ...
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INTRODUCTION: The COVID-19 (Coronavirus infectious disease 2019) pandemic has caused global behavioural changes due to the need to remain in quarantine by large groups of the population. Earlier work on the effects of other epidemics on the human psyche has revealed a possible increase in the number of people who abuse alcohol as a method of coping with mental stress. Despite this, the studies on the COVID-19 pandemic have not shown a clear correlation between lockdowns and quarantines and an increase in alcohol consumption. This study focused on examining the impact of the pandemic on the number of alcohol-related attendances in the Emergency Department in Poznan (Poland). MATERIAL AND METHODS: The periods of one year before the pandemic (control trial) and the first year of the COVID-19 pandemic (study group) were analysed retrospectively using the data of ED patients who were under the documented influence of alcohol. Total number, alcohol concentration, waiting time for a medical examination, the patient’s aggressive behaviour, length of stay in the ED, the need for additional examinations, suturing wounds or endotracheal intubation were analysed. RESULTS: 954 patients were identified, which constituted 2.9% of all patients admitted to the ED during this period (the total number of patients admitted was 33510). During the control period, the total number of ED admissions was 30388 and 794 (2.6%) of them were in the control group. The median body alcohol concentration was 2.6%%. It has been shown that during the pandemic more women and fewer men under the influence of alcohol were admitted to the ED (212 (22.2%) females and 742 (77.8%) males) than in the pre-pandemic period [135 (17.0%) females and 659 (83.0%) males]. Additional examinations were performed less frequently (84.1% vs. 73.9%; p = 0.00000) and patients were admitted to other departments more often (25.7% vs. 40.9%; p = 0.00000). Other examined parameters did not change significantly. CONCLUSIONS: The study shows an increase in the number of patients under the influence of alcohol during the pandemic presenting to the ED and a noticeable change in management patterns’ variables such as shorter LOW, fewer performed laboratory tests and more admissions to wards. However, this data requires further analysis and comparison with studies from other centres to draw more general conclusions.
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Objective Alcohol use disorders confer a significant burden of disease and economic cost worldwide. However, the utilisation of pharmacotherapies to manage alcohol use disorder is poor. We aimed to conduct a systematic review of economic evaluation studies of alcohol use disorder pharmacotherapies. Methods A search was conducted in Embase, Medline, CINAHL, PsychINFO and EconLit (August 2019, updated September 2022). Full economic evaluations using pharmacotherapy to treat alcohol use disorders were included. Included studies were stratified by medication and summarised descriptively. The Consensus on Health Economic Criteria list was used to assess the methodological quality. Results A total of 1139 studies were retrieved, of which 15 met the inclusion criteria. All studies were conducted in high-income countries. Four studies analysed nalmefene, four studies assessed acamprosate, three for naltrexone and four for stand-alone and/or combinations of naltrexone and acamprosate. There were 21 interventions synthesised from 15 studies as some studies evaluated multiple interventions and comparators. More than half of the included studies (73%) reported pharmacotherapy as dominant (less costly and more effective than comparators). From healthcare payer perspectives, five studies found that pharmacotherapy added to psychosocial support was dominant or cost-effective, accruing additional benefits at a higher cost but under accepted willingness to pay thresholds. Three analyses from a societal perspective found pharmacotherapy added to psychosocial support was a dominant or cost-effective strategy. Quality scores ranged from 63% to 95%. Conclusion Pharmacotherapy added to psychosocial support was cost-effective from both healthcare and societal perspectives, emphasising an increased role for pharmacotherapy to reduce the burden of alcohol use disorders.
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Alcohol misuse represents a universal public health concern that spans multiple demographics. As such, understanding shared, biological indicators of alcohol-related risk is vital to implementing targeted prevention and intervention efforts. Self-report measures of subjective response to alcohol (SR) capture both psychological and pharmacological effects of alcohol and robustly predict patterns of alcohol use, negative consequences, and the development of alcohol use disorders. Importantly, several biological markers of alcohol’s sedating effects, including cortisol, have been identified and complement subjective response assessments. However, biological markers of alcohol’s stimulating effects are less understood. Studies have implicated alcohol-induced changes in heart rate as a viable marker, but heart rate measurements are susceptible to measurement error. Salivary α-amylase, a reliable indicator of sympathetic nervous system activation, represents a promising alternative biomarker of alcohol-induced stimulation. Using data from a large, placebo-controlled alcohol administration study (N = 448), the present study examined the extent to which α-amylase is a viable marker of alcohol-induced stimulation. To test this, a measurement model was estimated in which baseline and ascending limb subjective stimulation latent variables were created using two validated measures of subjective response. Ascending self-reports of stimulation and levels of α-amylase were then regressed onto beverage conditions and allowed to correlate with each other. Findings indicated that α-amylase is sensitive to acute alcohol consumption and is positively, but not statistically reliably, related to the ascending limb stimulant SR. Future studies should consider including salivary α-amylase as a noninvasive physiological indicator of alcohol’s stimulating effects.
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Importance: Past studies have identified associations between brain macrostructure and alcohol use behaviors. However, identifying directional associations between these phenotypes is difficult due to the limitations of observational studies. Objective: To use mendelian randomization (MR) to identify directional associations between brain structure and alcohol use and elucidate the transcriptomic and cellular underpinnings of identified associations. Design, setting, and participants: The main source data comprised summary statistics from population-based and case-control genome-wide association studies (GWAS) of neuroimaging, behavioral, and clinical phenotypes (N = 763 874). Using these data, bidirectional and multivariable MR was performed analyzing associations between brain macrostructure and alcohol use. Downstream transcriptome-wide association studies (TWAS) and cell-type enrichment analyses investigated the biology underlying identified associations. The study approach was data driven and did not test any a priori hypotheses. Data were analyzed August 2021 to May 2022. Main outcomes and measures: Brain structure phenotypes (global cortical thickness [GCT] and global cortical surface area [GCSA] in 33 709 individuals and left-right subcortical volumes in 19 629 individuals) and alcohol use behaviors (alcoholic drinks per week [DPW] in 537 349 individuals, binge drinking frequency in 143 685 individuals, and alcohol use disorder in 8845 individuals vs 20 657 control individuals [total of 29 502]). Results: The main bidirectional MR analyses were performed in samples totaling 763 874 individuals, among whom more than 94% were of European ancestry, 52% to 54% were female, and the mean cohort ages were 40 to 63 years. Negative associations were identified between genetically predicted GCT and binge drinking (β, -2.52; 95% CI, -4.13 to -0.91) and DPW (β, -0.88; 95% CI, -1.37 to -0.40) at a false discovery rate (FDR) of 0.05. These associations remained significant in multivariable MR models that accounted for neuropsychiatric phenotypes, substance use, trauma, and neurodegeneration. TWAS of GCT and alcohol use behaviors identified 5 genes at the 17q21.31 locus oppositely associated with GCT and binge drinking or DPW (FDR = 0.05). Cell-type enrichment analyses implicated glutamatergic cortical neurons in alcohol use behaviors. Conclusions and relevance: The findings in this study show that the associations between GCT and alcohol use may reflect a predispositional influence of GCT and that 17q21.31 genes and glutamatergic cortical neurons may play a role in this association. While replication studies are needed, these findings should enhance the understanding of associations between brain structure and alcohol use.
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There is no doubt that smoking is damaging global health on an unprecedented scale. However, there is continuing debate on the economics of tobacco control, including the costs and consequences of tobacco control policies. This book aims to fill the analytic gap around this debate This book brings together a set of critical reviews of the current status of knowledge on tobacco control. While the focus is on the needs of low-income and middle- income countries, the analyses are relevant globally. The book examines tobacco use and its consequences including new analyses of welfare issues in tobacco consumption, poverty and tobacco, and the rationale for government involvement. It provides an evidence-based review of policies to reduce demand including taxation, information, and regulation. It critically reviews supply-side issues such as trade and industry and farming issues, including new analyses on smuggling. It also discusses the impact of tobacco control programs on economies, including issues such as employment, tax revenue and welfare losses. It provides new evidence on the effectiveness and cost-effectiveness of control interventions. Finally, it outlines broad areas for national and international action, including future research directions. A statistical annex will contain information on where the reader can find data on tobacco consumption, prices, trade, employment and other items. The book is directed at academic economists and epidemiologists as well as technical staff within governments and international agencies. Students of economics, epidemiology and public policy will find this an excellent comprehensive introduction to economics of tobacco control.
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Recent time-series analyses provide further support to the idea of a north–south gradient in Western Europe in alcohol's role in homicide. Differences in drunken comportment have long been hypothesized as part of the explanation. Five items about expectations about alcohol's role in violence, and the potential excuse-value of intoxication, were asked of 1,000 adults in an RDD survey in each of six countries: Finland, Sweden, the United Kingdom, Germany, France and Italy. The results were not in the expected direction. Finnish respondents were more likely than others to value not showing any effects after drinking. Italian, French and British respondents were the most likely to believe that getting drunk leads to violence. Italian, German and British respondents were most likely to believe that friends should forgive and forget after drunken anger, and Italians and British were the most likely to excuse behavior because of drunkenness. The results are discussed, and the interplay of the items, and within-population variations in responses to them, are explored comparatively in the six national samples.
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The present article identifies the theoretical areas in substance abuse estimation that have not been sufficiently addressed. Those include issues relating to the definition of social costs, a more comprehensive labour market analysis, the social benefits of drug consumption and the distributional impacts of substance abuse. Examples are presented of types of cost estimates, how the results of estimates can be interpreted and the policy use of each type of cost. Data requirements are identified and the process of proceeding from aggregate estimates to disaggregated evaluation is reviewed. Issues of attribution are considered, and the importance of calculation of avoidable costs of substance abuse is explained. General issues are reviewed with regard to benefit-cost analysis and evaluation criteria applicable to substance abuse. The article presents as a case study the economic evaluation of Quit Victoria. It uses the calculations of the social costs of tobacco to provide the basis of benefit-cost evaluation of Quit Victoria. The study resulted in a positive benefit-cost ratio under all assumptions. The article concludes with a review of the issues to be addressed in the economic evaluation of a medically supervised injecting room that is being undertaken in New South Wales, Australia. It emphasizes the importance of estimating social costs in project appraisal and public policy-making.