Bullous pemphigoid (BP) induced by radiotherapy

Maastricht University, Maestricht, Limburg, Netherlands
Radiotherapy and Oncology (Impact Factor: 4.36). 02/2007; 82(1):105. DOI: 10.1016/j.radonc.2006.11.013
Source: PubMed


The report of two patients who developed Bullous pemphigoid (BP) during radiotherapy (RT) of breast cancer is presented. The possible mechanisms and the risk factors were taken into concern during the development of BP. A patient diagnosed with breast cancer underwent breast sparing surgery. Gradually she developed a rash on both inner sides of her arms, which was imparted as an allergic reaction to her medication. Later irradiation for the right breast and periclavicular region was applied. As a result erythematosquamous conflating plaques with excoriations and blister formation confined to the radiation field developed after the 10th fraction. Later a skin biopsy specimen confirmed the diagnosis of BP. It can be concluded that both the patients developed a grade 1 radiation dermatitis independent of the BP and onset of BP. BP may therefore be considered as an early side effect of RT.

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