Morphologic asymmetry of the human anterior cingulate cortex

Center for Neuropsychological Research, University of Trier, Germany.
NeuroImage (Impact Factor: 6.36). 03/2007; 34(3):888-95. DOI: 10.1016/j.neuroimage.2006.10.023
Source: PubMed


The anterior cingulate cortex (ACC) is thought to play a major role in executive processes. Studies assessing neuroanatomical attributes of this region report a high degree of morphological variability. Recent theories consider the fissurization of the cortex to be a product of gross mechanical processes related to cortical growth and local cytoarchitectural characteristics. Hence, local sulcal patterning and gray matter volume are supposed to be associated. ACC fissurization was quantified in left- and right-handers of both sexes by recording the presence and extension of the paracingulate sulcus (PCS). Differences between groups regarding local gray matter volume were assessed by means of optimized voxel-based morphometry (oVBM) including additional modulation. Overall, the PCS occurred more often and was more pronounced in the left as compared to the right anterior cingulate region, although hemispheric differences were less pronounced in male left- and female right-handers. These discrepancies between groups seem to stem from variations of cingulate morphology in the left rather than the right hemisphere. The pattern of relevant comparisons in the oVBM analysis indicated a similar interaction. Therefore, evidence was found for discrepancies between groups and hemispheres on the macrostructural level.

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Available from: Rene J Huster, Mar 21, 2014
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    • "For the examination of hemispheric iFC asymmetry, the processing method was the same as that of our previous study (Yan et al., 2009), which referenced two previous studies (Gong et al., 2005a; Huster et al., 2007). Specifically, we generated a new set of z-maps by LR-flipping the individual z-maps of the right hemispheric seeds (the right superior dACC and the right inferior dACC). "
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    ABSTRACT: We aimed to elucidate the dACC laterality in typically developing children and their sex/age-related differences with a sample of 84 right-handed children (6–16 years, 42 boys). We first replicated the previous finding observed in adults that gray matter density asymmetry in the dACC was region-specific: leftward (left>right) in its superior part, rightward (left<right) in its inferior part. Intrinsic connectivity analysis of these regions further revealed region-specific asymmetric connectivity profiles in dACC as well as their sex and age differences. Specifically, the superior dACC connectivity with frontoparietal network and the inferior dACC connectivity with visual network are rightward. The superior dACC connectivity with the default network (lateral temporal cortex) was more involved in the left hemisphere. In contrast, the inferior dACC connectivity with the default network (anterior medial prefrontal cortex) was more lateralized towards the right hemisphere. The superior dACC connectivity with lateral visual cortex was more distinct across two hemispheres in girls than that in boys. This connection in boys changed with age from right-prominent to left-prominent asymmetry whereas girls developed the connection from left-prominent to no asymmetry. These findings not only highlight the complexity and laterality of the dACC but also provided insights into dynamical structure–function relationships during the development.
    Full-text · Article · Oct 2015 · Developmental Cognitive Neuroscience
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    • "In addition, anatomical tracing studies performed in rhesus monkeys point out neurons in the ACC project to the ventral striatum (Selemon and Goldman-Rakic, 1985). Emerging evidences revealed that DA levels, gray matter volume for ACC and rs-FC strength with ACC in the right hemisphere were greater than the left (Afonso et al., 1993; Paus et al., 1996; Huster et al., 2007; Yan et al., 2009; Watanabe et al., 2015). Hence, functional connectivity with the right ACC might be sensitive to slight changes in DA levels, which our research indicates are regulated by the interaction of the BDNF and COMT genes. "
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    ABSTRACT: The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine in the ventral striatum, while catechol-O-methyltransferase (COMT) impacts dopamine availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the dopamine-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral ventral striatum (VST) and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-relationship in COMT Met carriers, while COMT Val homozygotes displayed a U-relationship. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
    Full-text · Article · Apr 2015 · Neuroscience
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    • "Finally, the sulcal pattern of the ACC, by affecting the white matter connectivity , might constrain the development of the connectivity of the ACC to other areas of the brain, enabling this structure and other prefrontal structures to take control over these areas (Posner, 2012), which could explain why this qualitative structural characteristic of the brain partially explained the IC efficiency during childhood. Alternatively, given that previous studies have demonstrated that the sulcal pattern of the ACC have likely an impact on ACC activation (Amiez et al., 2013; Artiges et al., 2006; Crosson et al., 1999; Paus et al., 1998) and on quantitative characteristics of the structure of the ACC (e.g., cortical thickness, gray and white matter volumes, and surface area, see Paus et al., 1996a,b; Fornito et al., 2006a,b; Huster et al., 2007; Fornito et al., 2008), the constrain of the sulcal pattern of the ACC on IC efficiency reported in the present study could be mediated by the effect of the sulcal pattern of the ACC on the level of activation and/or quantitative characteristics of the structure of this region. However, we note that IC efficiency at age 5 and at age 9 were not associated with asymmetries in the thickness and surface area of the ACC at age 5. "
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