Preferential aggregation of obsessive-compulsive spectrum disorders in schizophrenia patients with obsessive-compulsive disorder

Department of Statistics and Operations Research, Tel Aviv University, Tell Afif, Tel Aviv, Israel
Canadian journal of psychiatry. Revue canadienne de psychiatrie (Impact Factor: 2.55). 11/2006; 51(12):746-54.
Source: PubMed


To validate a complex association between schizophrenia and obsessive-compulsive disorder (OCD).
We used the Structured Clinical Interview for DSM-IV Axis I disorders to compare the rate of OCD spectrum and additional Axis I disorders in 100 patients who met criteria for both schizophrenia and OCD, non-OCD schizophrenia (n = 100), and OCD (n = 35).
There was a robust between-group difference in the number of patients with one or more OCD spectrum disorders (schizo-obsessive n = 30, compared with schizophrenia n = 8; P = 0.001), that is, higher rates of body dysmorphic (8% compared with 0%) and tic (16% compared with 4%) disorders. No difference was revealed in affective, anxiety, and substance use disorders. We found comparable rates of OCD spectrum disorders in the schizo-obsessive and OCD groups (30% and 42.8%, respectively; P = 0.32).
Preferential aggregation of OCD spectrum disorders in the schizo-obsessive group supports this unique clinical association. Whether a schizo-obsessive interface represents comorbidity or a specific subtype of schizophrenia warrants further investigation.

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    • "Furthermore, OCS and OCD seem to be frequent also in the UHR (ultra high risk syndrome); indeed, a recent investigation found a prevalence of OCD of 14–20% in a sample of UHR youth (Niedman et al., 2009). Compared with schizophrenic patients, schizo-obsessive patients show a different pattern of comorbidity, with a preferential aggregation of OCD–spectrum disorders, namely body dysmorphic disorder, eating disorders, and tic disorders, but not major depressive, substance abuse, or anxiety disorders (Poyurosky et al., 2006). A fairly large number of studies have assessed, as a primary or a secondary aim, the impact of OCS or OCD on the severity of psychotic symptoms, and on the general outcome in schizophrenic patients. "
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    ABSTRACT: Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder affecting approximately 1-3% of the population. OCD is probably an etiologically heterogeneous condition. Individuals with OCD frequently have additional psychiatric disorders concomitantly or at some time during their lifetime. Recently, some authors proposed an OCD sub-classification based on comorbidity. An important issue in assessing comorbidity is the fact that the non-response to treatment often involves the presence of comorbid conditions. Non-responsive patients are more likely to meet criteria for comorbid axis I or axis II disorders and the presence of a specific comorbid condition could be a distinguishing feature in OCD, with influence on the treatment adequacy and outcome.
    Full-text · Article · Dec 2011 · Frontiers in Psychiatry
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    • "A metaanalysis revealed that the presence of obsessive-compulsive symptoms is associated with higher global, positive and negative schizophrenia symptom severity [15]. Compared with schizophrenia patients, schizo-obsessive patients show a different pattern of comorbidity, with a preferential aggregation of OCD-spectrum disorders, namely body dysmorphic disorder, eating disorders and tic disorders, but not of major depressive, substance abuse or anxiety disorders [16]. Important differences are also found in first-degree relatives of schizophrenia patients with and without obsessive-compulsive symptoms. "
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    ABSTRACT: Although obsessive-compulsive symptoms are not considered primary features, they are prevalent, independent of psychosis, and substantially modify clinical characteristics, course, treatment and prognosis of schizophrenia. The authors highlight the clinical significance of obsessive-compulsive symptoms in schizophrenia, provide diagnostic criteria for "schizo-obsessive" patients and address future directions for research.
    Full-text · Article · Oct 2011 · Comprehensive psychiatry
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