Phosphatidylcholine treatment to induce lipolysis. J Cosmet Dermatol 4:308-313

Therapy-Clinic Center, Bad Leonfelden, Austria.
Journal of Cosmetic Dermatology (Impact Factor: 0.88). 01/2006; 4(4):308-13. DOI: 10.1111/j.1473-2165.2005.00211.x
Source: PubMed


The medicine Lipostabil N has been in widespread use in Europe since 2002 by doctors working in the field of esthetics to achieve a reduction in the volume of smaller fat deposits by means of injections into the subcutaneous fatty tissue. The lipases released from the adipocytes by means of phosphatidylcholine produce a local breakdown of fat that is then discharged over the liver and metabolized via beta-oxidation. The medicine has been authorized for intravenous use in the prophylaxis and therapy of fat embolisms and liver diseases.

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    • "Partial lipolysis performed with PPC and DCA injection is more efficient, effective, and non-invasive technique than the liposuction and dermolipectomy that were previously performed. Some doctors are currently using this technique for treating buffalo hump, lipoma, and xanthelasma related to human immunodeficiency virus and some private clinics are using it for local fat removal of the thighs, flanks, neck, and face [1-7]. "
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    ABSTRACT: Phosphatidylcholine (PPC) and deoxycholate (DCA) compound has been recently used for the purpose of partial lipolysis and is valued for its efficacy and lower invasiveness compared to liposuction and dermolipectomy used previously. In this article, the authors discuss the efficacy of the PPC dissolved in DCA via an experimental rat study model, along with suggesting a useful animal experimental model for the study of adipose tissue and lipolysis. Bilateral inguinal fat pads of an experimental rat were elevated with the deep inferior epigastric vessel as the sole vascular pedicle. Normal saline was injected on one side as a control group and a PPC and DCA compound was injected on the other side. After 4 days, the rats were euthanized for microscopic tissue examination. The pathology was scored by a semiquantitative system in 4 categories: normal fat amount, fat necrosis, inflammatory activity, and stage of fibrosis. A Wilcoxon signed-rank test powered by SPSS packet program was used for statistical analysis and to determine significance. Microscopic examination was performed on the obtained samples, and the experimental data of all four categories showed significant histologic differences compared to the control group. All of the data also showed statistical significance by the Wilcoxon signedrank test (P<0.01). In the inguinal fat pad rat model, the control group and the experimental group had a differed significantly in the amount of normal fat tissue, inflammation, necrosis, and fibrosis. We recommend the rat inguinal fat pad model used in this study, as it is likely to be useful in related research.
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    • "It has been suggested that SD, the detergent in the PPC formulation, is the active lipodissolving substance, and not PPC [25]. The main side effects of injection of PPC formulations are relatively minor, and include swelling, bruising, and sensitivity to touch under the skin in areas with the lipodissolution treatments [26]. However, since injection of SD causes focal necrosis and inflammation in human lipomas [25], it is entirely conceivable that the aforementioned side effects of PPC formulations are due to SD, not to PPC itself. "
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    ABSTRACT: Phosphatidylcholine (PPC) formulation is used for lipolytic injection, even though its mechanism of action is not well understood. The viability of 3T3-L1 pre-adipocytes and differentiated 3T3-L1 cells was measured after treatment of PPC alone, its vehicle sodium deoxycholate (SD), and a PPC formulation. Western blot analysis was performed to examine PPC-induced signaling pathways. PPC, SD, and PPC formulation significantly decreased 3T3-L1 cell viability in a concentration-dependent manner. PPC alone was not cytotoxic to CCD-25Sk human fibroblasts at concentrations <1 mg/ml, whereas SD and PPC formulation were cytotoxic. Western blot analysis demonstrated that PPC alone led to the phosphorylation of the stress signaling proteins, such as p38 mitogen-activated protein kinase and c-Jun N-terminal kinase, and activated caspase-9, -8, -3 as well as cleavage of poly(ADP-ribose) polymerase. However, SD did not activate the apoptotic pathways. Instead, SD and PPC formulation induced cell membrane lysis, which may lead to necrosis of cells. PPC results in apoptosis of 3T3-L1 cells.
    Full-text · Article · Dec 2011 · Journal of Biomedical Science
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    ABSTRACT: SUMMARY Primary presentation of classic Kaposi's sarcoma (KS) on penis is extremely infrequent; with only 51 cases reported so far. We report two patients with the histopathologic diagnosis of KS. The first was a 59 year old male patient with a 6x7mm nodule, tender to palpation, wine-red colored, on the ventral surface of the glans. He died few months later with diagnosis of lymphoma. The second was a 64 year old male patient with nodular lesions on the left lower extremity and red-violaceus macules on the body of the penis and the coronal sulcus. He had negative serology for HIV. In conclusion, classic KS with primary presentation on penis is an uncommon pathology, but should be considered when treating unspecific lesions on penis.
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