A Common Progenitor at the Heart of Development

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Cell (Impact Factor: 32.24). 01/2007; 127(6):1101-4. DOI: 10.1016/j.cell.2006.11.031
Source: PubMed


Formation of the heart requires the coordinated functions of cardiac myocytes, smooth muscle cells, endothelial cells, and connective tissue elements. Several recent studies now reveal that these different cell types arise from a common progenitor (Kattman et al., 2006; Moretti et al., 2006; Wu et al., 2006). These findings raise interesting questions about the lineage relationships of cardiovascular progenitor cell populations and suggest possibilities for cardiac repair in both congenital and acquired heart disease.

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    • "The heart represents one of the first functional organs to form during development (Garry and Olson, 2006). Retrospective clonal analysis, in which cardiac progenitors are labeled randomly during cardiac development, has suggested that heart morphogenesis involves two distinct groups of cardiac progenitors called first and second heart field (FHF and SHF, respectively ) (Buckingham et al., 2005). "
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    • "Embryonic stem cells (ESCs), described on humans by Thompson [27] are the prototypical stem cells. They unambiguously fulfill all requirements of stem cells: clonality, self renewal and multipotentiality [28]. ES are able to differentiate into any adult cells and can efficiently generate both functional beating mature CMCs and vasculature; however, their therapeutic use is hampered by associated teratoma formation and the need for an allogeneic source [29]. "
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