Extract of Pelargonium sidoides (EPs® 7630) improves phagocytosis, oxidative burst, and intracellular killing of human peripheral blood phagocytes in vitro
Clinical data show that EPs® 7630, an aqueous ethanolic extract from the roots of Pelargonium sidoides, can be used for the treatment of upper respiratory tract infections (URTI). The biological effects of the preparation have not been fully investigated. The objective of this study was to examine the impact of EPs® 7630 on the activity of human peripheral blood phagocytes (PBP). A whole blood-based, flow cytometric assay was used to simultaneously assess phagocytosis and oxidative burst. EPs® 7630 was applied in therapeutically relevant concentrations between 0 and 30 ?g/ml. Compared with controls EPs® 7630 increased the number of phagocytosing PBP in a concentration-dependent manner, with a maximum enhancement of 56% at 2 min. The application of EPs® 7630 also led to a significant increase in the number of burst-active PBP for all time points observed beyond 2 min. Using a microbiological assay, intracellular killing was also enhanced by EPs® 7630. In conclusion, the positive effects of EPs® 7630 on phagocytosis, oxidative burst, and intracellular killing of yeast cells as test organisms are important components of the compound's biological activity. Our findings constitute a valuable contribution to understanding the clinical effects of EPs® 7630.
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