Altered innate and adaptive immune responses in patients with hidradenitis suppurativa

4th Department of Internal Medicine, Univeraity of Athens, Medical School, University General Hospital Attikon, 1 Rimini Street, 124 64 Athens, Greece.
British Journal of Dermatology (Impact Factor: 4.28). 02/2007; 156(1):51-6. DOI: 10.1111/j.1365-2133.2006.07556.x
Source: PubMed


The clinical improvement of hidradenitis suppurativa reported in a small number of patients with antitumour necrosis factor (anti-TNF)-alpha therapies supports the hypothesis for an altered immune response in these patients.
To evaluate the state of the innate and adaptive immune responses in patients with hidradenitis suppurativa.
Fifty-three patients and six healthy controls were studied. Blood was sampled and subpopulations of lymphocytes were analysed by flow cytometry; monocytes were isolated and their function was evaluated from the concentrations of TNF-alpha and interleukin (IL)-6 in supernatants of cell cultures after triggering with endotoxins (lipopolysaccharides). TNF-alpha and IL-6 were estimated by an enzyme immunoassay.
CD3/CD8 lymphocytes were lower in patients with involvement of the perineum than in controls; patients with involvement of the breast had higher levels of natural killer (NK) cells than controls. A negative correlation was found between years lapsing since initial presentation of lesions of hidradenitis and the percentage of NK cells. Monocytes isolated from healthy volunteers were more active for the secretion of TNF-alpha and IL-6 than those of patients with hidradenitis suppurativa.
A reduction in the percentage of NK cells over time and a lower monocyte response to triggering by bacterial components is observed in patients with hidradenitis suppurativa. Further research is needed to clarify if these changes are connected to an autoimmune mechanism in the pathogenesis of hidradenitis suppurativa.

21 Reads
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The paper is directed to the subject of highway communication as related to enhancement of safety and services on the national road network. Included is a discussion of the transmission means by which an integrated multi-purpose system, having a relatively-high degree of efficiency in use of the radio spectrum, may be effectuated. Reference is made to the proceedings and preliminary report of the first National Conference on Highway Communication for Service and Safety at Denver in August, 1967. Issues raised by a petition to the FCC by the Automobile Manufacturers Association to establish a Highway Emergency Locating Plan (HELP) in the Citizens Radio Band are summarized. Potential advantages that appear to be presented by use of an integrated system of roadsidecable type and the various communication and control functions that such a system might provide are discussed. The concluding portion of the paper relates to the need to define what services are feasible and desired on a long-range basis; the need to outline and establish parameters relating to preferred types of systems; and the need to explore and determine means by which proposed systems can be financed, operated and maintained.
    Preview · Conference Paper · Jan 1968
  • Source

    Preview · Article · Jan 1981
  • [Show abstract] [Hide abstract]
    ABSTRACT: We measured the responses of a circumaural and a supraaural headphone on 14 subjects and a head and torso simulator (HATS) with a simplified ear simulator terminated in a resistance, which has been originally developed for the simulated in-situ measurements of hearing aids. The sound pressure at the earcanal entrance of the subjects and the HATS was picked up by the probe tube microphone. The headphones were excited by white noise and their frequency responses were calculated by cross spectrum method for FIR system identification. The measured headphone responses on the HATS agree with the average responses of the real ears below 6 kHz.
    No preview · Conference Paper · May 1986
Show more