Carmona-Saez P, Chagoyen M, Tirado F, Carazo JM, Pascual-Montano AGENECODIS: a web-based tool for finding significant concurrent annotations in gene lists. Genome Biol 8: R3

BioComputing Unit, National Center of Biotechnology (CNB-CSIC), C/Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain.
Genome biology (Impact Factor: 10.81). 02/2007; 8(1):R3. DOI: 10.1186/gb-2007-8-1-r3
Source: PubMed


We present GENECODIS, a web-based tool that integrates different sources of information to search for annotations that frequently co-occur in a set of genes and rank them by statistical significance. The analysis of concurrent annotations provides significant information for the biologic interpretation of high-throughput experiments and may outperform the results of standard methods for the functional analysis of gene lists. GENECODIS is publicly available at

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    • "and gene names corresponding to the identified proteins were added. A bioinformatic analysis was conducted using GeneCo- dis3 [18] [19] [20]. Gene names corresponding to the identified proteins were entered in GeneCodis3 to conduct Gene Ontology cellular component analysis. "
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    • "Current methods for overrepresentation analysis have become a de facto standard for molecular biological research [33]. A large number of gene set enrichment methods have been developed for analyzing gene set enrichment [6] [14] [15] [18] [23] [31] [32] [33]. Each of these methods employs a different test statistic and null hypnosis to estimate the amount of differential expression of genes. "
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