The epidemiology of preterm labour - Why have advances not equated to reduced incidence?

Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, London, UK.
BJOG An International Journal of Obstetrics & Gynaecology (Impact Factor: 3.45). 01/2007; 113 Suppl 3(supplement 3):1-3. DOI: 10.1111/j.1471-0528.2006.01116.x
Source: PubMed


The major burden of preterm birth is in the developing world, where most of the increasing death and morbidity is secondary to infectious diseases such as malaria, HIV, tuberculosis, bacterial vaginosis and intestinal parasites. In some developing countries, the growth of medical care has outstripped the growth of preventive public health, with an associated increase in iatrogenic preterm births. In developed countries, more than one-third of preterm births are medically indicated because of conditions such as fulminating pre-eclampsia or severe intrauterine growth restriction. Neither of these conditions is currently preventable. One in five preterm births is associated with multiple pregnancy, and these have been greatly increased by assisted reproduction techniques. The use of tocolytics has proved disappointing perhaps because inflammation rather than spontaneous uterine activity is increasingly recognised as the final common pathway. Inappropriate antibiotics used late in pregnancy are ineffective and may have adverse effects. Currently, the most promising interventions are public health related and include reducing the transmission of communicable diseases, improvements in the management of diabetes and reduction in harmful behaviours such as smoking and drug abuse.

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    • "Black women have double the rates of PTB as white women and women with a previous preterm delivery have a 15–50% recurrence risk [8]. Increasing prevalence of assisted reproductive technology and multiple gestations [10], as well as maternal and fetal indications including hypertension, diabetes, and intrauterine growth restriction contribute to rates of PTB [11]. "
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