Role of Unsaturated Fatty Acid Biosynthesis in Virulence of Streptococcus mutans

Department of Microbiology and Immunology, Center for Oral Biology, Rochester, NY 14642, USA.
Infection and Immunity (Impact Factor: 3.73). 04/2007; 75(3):1537-9. DOI: 10.1128/IAI.01938-06
Source: PubMed


An insertionally inactivated fabM strain of Streptococcus mutans does not produce unsaturated membrane fatty acids and is acid sensitive (E. M. Fozo and R. G. Quivey, Jr., J. Bacteriol. 186:4152-4158, 2004). In this study, the strain was shown to be poorly transmissible from host to host. Animals directly infected with the fabM strain exhibited fewer and less severe carious lesions than those observed in the wild-type strain. Copyright © 2007, American Society for Microbiology. All Rights Reserved.

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Available from: Elizabeth M Fozo, Aug 28, 2014
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    • "Inactivation of the gene responsible for biosynthesis of monounsaturated fatty acids, fabM, resulted in a strain that was extremely sensitive to low pH and unable to maintain ΔpH (Fozo & Quivey, 2004a). Rats infected with the fabM mutant exhibited substantially reduced caries, as compared to the parent strain (Fozo et al., 2007). "
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