Revised Response Criteria for Malignant Lymphoma

University of Cologne, Köln, North Rhine-Westphalia, Germany
Journal of Clinical Oncology (Impact Factor: 18.43). 03/2007; 25(5):579-86. DOI: 10.1200/JCO.2006.09.2403
Source: PubMed


Standardized response criteria are needed to interpret and compare clinical trials and for approval of new therapeutic agents by regulatory agencies.
The International Working Group response criteria (Cheson et al, J Clin Oncol 17:1244, 1999) were widely adopted, but required reassessment because of identified limitations and the increased use of [18F]fluorodeoxyglucose-positron emission tomography (PET), immunohistochemistry (IHC), and flow cytometry. The International Harmonization Project was convened to provide updated recommendations.
New guidelines are presented incorporating PET, IHC, and flow cytometry for definitions of response in non-Hodgkin's and Hodgkin's lymphoma. Standardized definitions of end points are provided.
We hope that these guidelines will be adopted widely by study groups, pharmaceutical and biotechnology companies, and regulatory agencies to facilitate the development of new and more effective therapies to improve the outcome of patients with lymphoma.


Available from: Malik Juweid, Sep 17, 2015
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    • "All lesion assessments, whether by physical examination or radiologic methods, were repeated by the same methods at least 4 weeks following the initial observation of an objective response for response confirmation. Responses were recorded based on Response Evaluation Criteria in Solid Tumors,version 1.0 (RECIST 1.0), and Revised Response Criteria for Malignant Lymphoma [38, 39]. "
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    • "Associations between miRNA expression and BAGS, REGS, and ABC/GCB were investigated using ANOVA, Pearson's correlation, and/or Student's t tests. The impact of expression of miR-34a on overall survival (OS) and progression-free survival (PFS), as defined by Cheson et al. [19] , was evaluated with Kaplan–Meier estimates , log-rank tests, and Cox proportional hazards regression analyses. The impact of overexpression of miR-34a by lentiviral transduction in response to doxorubicin was evaluated with Student's t test. "
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    • "Compliance to national guidelines was also reported by the ten largest haematology/oncology centres in Sweden, although we cannot formally exclude that individual physicians used other strategies. Finally, we included patients with CR determined by either conventional or PET/CT-based response criteria (Cheson et al, 1999Cheson et al, , 2007). PET/CT restaging was used in 70% of the Danish patients and 86% of the Swedish patients (P < 0Á01) but patients with PET/CT-based CR had similar OS as patients with CR by conventional response (Fig 4 and Table SI). "
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