Jones-Caballero M, Chren MM, Soler B et al.Quality of life in mild to moderate acne: relationship to clinical severity and factors influencing change with treatment. J Eur Acad Dermatol Venereol 21:219-226

University of California, San Francisco, San Francisco, California, United States
Journal of the European Academy of Dermatology and Venereology (Impact Factor: 2.83). 03/2007; 21(2):219-26. DOI: 10.1111/j.1468-3083.2006.01907.x
Source: PubMed


Because of its effects on quality of life, acne vulgaris is more than a merely physiological or cosmetic entity.
To describe the influence of mild to moderate acne on patients' quality of life, measured using Skindex-29, and to correlate changes in Skindex-29 scores with changes in objective and subjective indices in clinical severity after treatment with topical 4% erythromycin 0.2% zinc. Also, to evaluate efficacy and side-effects of the treatment.
Observational, prospective study of 1878 patients cared for by 252 clinicians in Spain. Data included epidemiological information and responses to Skindex-29, a subjective change and objective severity index.
Baseline Skindex scale scores were worse in women, older patients, and those with more severe clinical disease. Skindex was sensitive to changes in objective severity but changes in Skindex scale scores were also related to other factors. Patients who reported their skin condition to be 'the same' or 'worse' at the end of the study had significantly worse baseline scores on the 'symptoms' and 'emotions' scales but 'functioning' scores were not worse than for those who reported their condition had improved.
The effects of acne vulgaris on quality of life and changes in quality of life after treatment are not only explainable by objective severity of acne. Patients' and clinicians' judgements about acne severity are different.

Download full-text


Available from: Begoña Soler, May 22, 2015
  • Source
    • "Lasek and Chren DLQI 1998 USA [24] Jones-Caballero et al. Skindex-29 2007 Spain [25] "
    [Show abstract] [Hide abstract]
    ABSTRACT: Background. Acne vulgaris is a common skin disease that can adversely affect the quality of life of patients. Objective. The aim of this study was to determine the quality of life in patients with acne vulgaris. Methods. This study was carried out on 70 patients with acne vulgaris (28 males, 42 females). All the patients filled out two Persian versions of questionnaires: short form 36 (SF-36) and Dermatology Life Quality Index (DLQI). The obtained data were analyzed by using SPSS software (version 17). Results. The scores for physical functioning, social functioning, and bodily pain domains in patients were over 70%, but the scores for role physical, general health, vitality, role emotional, and mental health in patients were under 70%. Scores on the DLQI in patients with acne vulgaris ranged from 0 to 22 (mean ± SD, 8.18 ± 4.83). After comparing mean score of DLQI with respect to gender and age, it was found that the difference between the two groups was not statistically significant. Conclusion. Acne vulgaris has a significant effect on the quality of life. There was not any significant gender or age related difference in QOL.
    Full-text · Article · Nov 2013 · Dermatology Research and Practice
  • Source
    • "This is the first trial to evaluate the QOL of pregnant women with striae gravidarum, and so no comparison of results among studies or calculation of an adequate sample size could be conducted. The sample size was based on those in the previous studies which used Skindex-29 [23-26]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Striae gravidarum is a physiological skin change that many pregnant women experience during pregnancy. The striae are often accompanied by a reddish purple color during pregnancy, and then lose pigmentation and become atrophic in the long term after pregnancy. Striae gravidarum seems to be undesirable to many pregnant women. However, the impact of striae gravidarum on pregnant women who experience it has not been clarified. The aim of this study was to evaluate the impact of striae gravidarum on the generic and dermatology-specific quality of life (QOL) of pregnant women. A cross-sectional study was conducted at three private clinics in a typical urban area in Japan. We recruited 447 pregnant women at 36 weeks of gestation; One hundred and ninety-nine pregnant women at 36 weeks of gestation participated in the study and 179, consisting of 94 primiparae and 85 multiparae, were analyzed. We used and assessed Davey’s score for striae gravidarum, World Health Organization Quality of Life assessment questionnaire for generic QOL, and Skindex-29 for dermatology-specific QOL. The prevalence of striae gravidarum was 39.1% (27.7% in primiparae, and 51.8% in multiparae). Although there were no differences in generic QOL scores between the presence and absence of striae gravidarum and with their severity, the whole group of pregnant women and the multiparae group showed significant differences in scores on emotion of Skindex-29 between the presence and absence of striae gravidarum (p = 0.012 and p = 0.011). Pregnant women with severe striae gravidarum showed significantly higher scores on emotion of Skindex-29 compared with those with absent or mild striae gravidarum (p < 0.001 and p = 0.005). There was no difference in generic QOL of pregnant women between the presence and absence of striae gravidarum, although the occurrence and severity of striae gravidarum influenced their dermatology-specific QOL. Multiparae women were especially impaired by striae gravidarum and it is considered important to prevent or reduce the severity of striae gravidarum of the multiparae group.
    Full-text · Article · Aug 2012 · BMC Research Notes
  • Source
    • "Moreover, when acne was compared with other diseases, acne patients reported levels of social, psychological and emotional problems that were as great as those reported by patients with chronic disabling asthma, epilepsy, diabetes, back pain or arthritis. Therefore, acne is not a trivial disease in comparison with other chronic conditions [2]. There is generally a linear relationship between the clinical severity of acne and impairment of HRQoL, although impairment is also dependent upon a person’s ‘coping ability’. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Acne is a very common condition and has a substantial impact on patients' quality of life. This study was carried out to determine the impact of acne and its clinical severity on health related quality of life in a group of patients attending private clinic in Erbil city, Iraq. A cross-sectional study was conducted between July 1st, 2011 and November 1st, 2011. A convenience sample of 510 patients attending private clinic in Erbil city was taken. Verbal informed consent was obtained from all participants. The Cardiff acne disability index (CADI) was used in this study. The sample included 510 patients (173 males and 337 females); their mean ± SD age was 20.08 ± 4.23 years (ranged from 11 to 36 years) with a male: female ratio of 0.41:1. The mean ± SD ages of males and females were 18.62 ± 3.19 and 20.83 ± 4.49 years, respectively (P < 0.001). Results revealed that there is significant association between age and quality of life impairment (P < 0.001), and it revealed that quality of life was more impaired (47.2%) among female than that (37.6%) among male patients (P = 0.038). There was significant association between grading of acne and QOL impairment (P < 0.0001). Acne negatively affects quality of life, females were more affected than the males, age group 21-25 more than the other age groups and the greater the grade "severity" of acne, the greater the level of impairment of quality of life.
    Full-text · Article · Jun 2012 · Health and Quality of Life Outcomes
Show more