Copious Pre-Ejaculation: Small Glands--Major Headaches

Division of Andrology, University of Illinois, Chicago, USA.
Journal of Andrology (Impact Factor: 2.47). 12/2006; 28(3):374-5. DOI: 10.2164/jandrol.107.002576
Source: PubMed


Note: Postings to Androlog have been lightly edited before publication. Pre-ejaculate is a clear mucoid fluid produced by accessory sex glands and expressed on sexual stimula- tion into the urethra. The organs that produce this fluid are Cowper glands, the glands of Littre, and possibly the glands of Morgagni. Pre-ejaculate volume may range in normal men from a few drops to more than 5 mL. Pre- ejaculate functions naturally as a chemical neutralizer to the urine's residual acidity in the urethra and thus provides the basic pH of the semen, allowing for safe passage of sperm (Chughtai et al, 2005). Investigators have accumulated a significant body of knowledge about the chemical composition of pre- ejaculate and have compared sex gland secretions for different age groups. An abundance of researchers have studied the presence of human immunodeficiency (HIV) and other sexually transmitted diseases in the pre- ejaculate fluid. Reports in the literature also have discussed the presence or absence of sperm in the pre- ejaculate and whether or not it is safe to practice withdrawal (coitus interruptus) as a means of contracep- tion. However, a relative paucity of research exists describing normal amounts of pre-ejaculate and the possible social-sexual consequences that excessive fluid might render. The majority of reports describing exces- sive pre-ejaculate include anecdotal evidence, personal communications, and speculation based on knowledge of the physiology of the reproductive system. Yet excessive pre-ejaculate is a documented fact, and several experts in the field recently discussed this problem.

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