Article

Peri-implantation glucocorticoid administration for assisted reproductive technology cycles

Utrecht University, Utrecht, Utrecht, Netherlands
Cochrane database of systematic reviews (Online) (Impact Factor: 6.03). 02/2007; 1(1):CD005996. DOI: 10.1002/14651858.CD005996.pub2
Source: PubMed

ABSTRACT

Glucocorticoids are a class of steroid hormones, with potent anti-inflammatory and immunosuppressive properties. In order to improve embryo implantation in in-vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) cycles, the use of glucocorticoids has been advocated to improve the intra-uterine environment. This review investigates whether the administration of glucocorticoids around the time of implantation improves clinical outcomes in women undergoing IVF or ICSI, compared to no glucocorticoid administration. The review of trials found no evidence that glucocorticoids helps to improve birth rates. However, there is some evidence of increased pregnancy rates among women undergoing IVF (rather than ICSI). More research is needed to elucidate the possible role of this therapy in well defined patient subgroups.

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    • "Boomsma et al. [50] proposed that glucocorticoids could improve fertilization by acting as immune modulators to reduce the uterine NK cell count and normalize the cytokine expression profile in the endometrium by suppressing endometrial inflammation. They showed that use of glucocorticoids in women undergoing IVF was associated with a borderline statistically significant improvement in pregnancy rates. "
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    ABSTRACT: Reproductive changes such as impaired fertility and adverse pregnancy outcomes have been related to female asthma. We recently found that time to pregnancy is prolonged in asthmatic females especially in women with moderate to severe asthma and in those above 30 years of age. Despite their reproductive difficulties the asthmatics ultimately conceived just as many biological children as healthy throughout their reproductive lives. This knowledge therefore raises questions about how asthma affects fertility pathophysiologically. The purpose of this review is to describe the existing knowledge in this field and suggest hypotheses of causal relationships, which may form the basis for future studies in this field. The aim is, in particular, in the literature to examine whether there is any evidence to suggest that the systemic inflammation that characterizes asthma, can affect fertility. The issue is potentially clinically important for asthmatic, infertile individuals and society because treatment of the general systemic inflammation associated with the asthmatic disease combined with hormone stimulation might be the optimal target for an effective infertility therapy, possibly decreasing the need for in vitro fertilization.
    Full-text · Article · Mar 2014
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    • "Similarly, in the presence of ACA (anti-cardiolipin antibodies ), the use of heparin and aspirin showed no benefit (Stern et al., 2003). Attempts of administering steroids (Boomsma et al., 2007) or low-dose aspirin (Gelbaya et al., 2007) were also negative. "
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    ABSTRACT: Background: The American Society for Reproductive Medicine (ASRM) and the European Society of Human Reproduction and Embryology (ESHRE) are the two largest societies in the world whose members comprise the major experts and professionals working in the field of reproductive medicine and embryology. These societies have never before had a joint scientific meeting. Method(s): A 3-day meeting was planned and took place in March of 2012. The goal was to present and debate key topics, as well as modes of practice in reproductive medicine and to discuss recent developments in the field. Result(s): Presentations by members of ASRM and ESHRE were of three types: 'state of the art' lectures, 'back-to-back' presentations of two points of view and debates. Conclusion(s): For the first time, ASRM and ESHRE held a joint meeting where a special emphasis was given to presentations on the hottest topics in the field. Although different opinions and approaches sometimes exist on the two sides of the Atlantic, an appreciation and acceptance of these differences was evident, and there was more commonality than divergence of opinion.
    Full-text · Article · Oct 2012 · Fertility and sterility
    • "Similarly, in the presence of ACA (anti-cardiolipin antibodies), the use of heparin and aspirin showed no benefit (Stern et al., 2003). Attempts of administering steroids (Boomsma et al., 2007) or low-dose aspirin (Gelbaya et al., 2007) were also negative. "
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    ABSTRACT: BACKGROUND The American Society for Reproductive Medicine (ASRM) and the European Society of Human Reproduction and Embryology (ESHRE) are the two largest societies in the world whose members comprise the major experts and professionals working in the field of reproductive medicine and embryology. These societies have never before had a joint scientific meeting. METHODSA 3-day meeting was planned and took place in March of 2012. The goal was to present and debate key topics, as well as modes of practice in reproductive medicine and to discuss recent developments in the field. RESULTSPresentations by members of ASRM and ESHRE were of three types: 'state of the art' lectures, 'back-to-back' presentations of two points of view and debates. CONCLUSIONS For the first time, ASRM and ESHRE held a joint meeting where a special emphasis was given to presentations on the hottest topics in the field. Although different opinions and approaches sometimes exist on the two sides of the Atlantic, an appreciation and acceptance of these differences was evident, and there was more commonality than divergence of opinion.
    No preview · Article · Oct 2012 · Human Reproduction
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