Daley, G. Q. et al. The ISSCR guidelines for human embryonic stem cell research. Science 315, 603-604

University of Toronto, Toronto, Ontario, Canada
Science (Impact Factor: 33.61). 03/2007; 315(5812):603-4. DOI: 10.1126/science.1139337
Source: PubMed


The International Society for Stem Cell Research describes major principles that should guide ethical stem cell research.

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    • "Our data reveal a hidden unity in vertebrate mesoderm induction and suggest that the streak is not a defining feature of amniote mesoderm formation. Because the streak is an important criterion in ethical debates surrounding the use and in vitro culture of human stem cells (Daley et al., 2007), the embryological definition and evolutionary significance of the streak deserve re-evaluation. "
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    ABSTRACT: Mesoderm is formed during gastrulation. This process takes place at the blastopore in lower vertebrates and in the primitive streak (streak) in amniotes. The evolutionary relationship between the blastopore and the streak is unresolved, and the morphogenetic and molecular changes leading to this shift in mesoderm formation during early amniote evolution are not well understood. Using the chick model, we present evidence that the streak is dispensable for mesoderm formation in amniotes. An anamniote-like circumblastoporal mode of gastrulation can be induced in chick and three other amniote species. The induction requires cooperative activation of the FGF and Wnt pathways, and the induced mesoderm field retains anamniote-like dorsoventral patterning. We propose that the amniote streak is homologous to the blastopore in lower vertebrates and evolved from the latter in two distinct steps: an initial pan-amniote posterior restriction of mesoderm-inducing signals; and a subsequent lineage-specific morphogenetic modification of the pre-ingression epiblast.
    Full-text · Article · May 2013 · Development
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    • "International Society for Stem Cell Research (ISSCR) (Daley et al. 2007) presume that moral and bioethical considerations are shared equally on a global level. To put into perspective the difficulties related to such recommendations in the context of a large developing country, this article emphasises some of the material aspects of the risk perception of human embryonic stem cell research, examining the readings by Chinese 2 This article has benefited from research support provided by the Netherlands Organisation of Science (NWO) and the ESRC (RES-350-27-002; RES-062-23--0215). "
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    ABSTRACT: The international development of human embryonic stem cell research has become closely tied to global bioethics, which places moral responsibility on stem cell researchers. This article argues that the development of bioethical regulation of human embryonic stem cell research is better understood by approaching the institutionalisation of bioethics in terms of risk perceptions of stem cell scientists. Eschewing approaches that understand bioethical risk as a mere matter of morality or as a social construct, this article emphasises the materiality and strategic reasoning of bioethical views on risks associated with human embryonic stem cell research. Such an approach allows the identification of forms of risk rooted in the everyday practice of Chinese human embryonic stem cell research, including moral risk (as a violation of cultural values), material risk (in relation to the distribution of material resources and wealth), political risk (in terms of the political economy of bioethics and public debate) and reputational risk (in terms of personal and national honour). Although this analysis builds on Tom Horlick-Jones's concept of risk signatures of new technologies, which emphasise the capacities of different technologies to engender and delimit the particular social and cultural interpretations of the risks they generate, the article reveals the existence of a certain global awareness among stem cell scientists of risk signatures. They display a creative and strategic awareness regarding the possible opportunities and constraints the risk signature of human embryonic stem cell research affords in their particular institutional context compared to those of others abroad and at home in different environments. The existence of this form of reflexivity requires recognition and methodological accommodation.
    Full-text · Article · Oct 2010 · Health Risk & Society
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    • "the broader social, ethical, and legal implications in addition to setting professional standards for research conduct and clinical application (Daley et al., 2007; ISSCR, 2006; ISSCR 2008a; Taylor, 2007; Hyun et al., 2008). The latter guidelines include a stand-alone appendix, a ''Patient Handbook on Stem Cell Therapies'' to directly address the concerns of patients (ISSCR, 2008b). "
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    ABSTRACT: A report by the International Society for Stem Cell Research (ISSCR)'s Task Force on Unproven Stem Cell Treatments outlines development of resources for patients, their families, and physicians seeking information on stem cell treatments.
    Full-text · Article · Jul 2010 · Cell stem cell
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