Divided naevus of the eyelid, seven cases
University of Athens, Laikon General Hospital, 2nd Propedeutic Surgical Department, Greece.Journal of Plastic Reconstructive & Aesthetic Surgery (Impact Factor: 1.42). 02/2007; 60(3):260-5. DOI: 10.1016/j.bjps.2005.12.032
Divided naevus of the upper and lower lids is an infrequent congenital naevus of the human eyelids. It is also known as kissing naevus or split ocular naevus. The histological types of divided naevi may be melanocytic, cellular or compound. Until now about 30 such cases have been reported in the literature. In our clinic, in the last 20 years we have seen seven patients with divided naevus, four female and three male. Three patients, two children of 10 and 11 years and a 77-year-old nun, did not accept any treatment. The remaining four patients, three female and one male, accepted surgical treatment. None of them had received any treatment in the past. Three of these divided naevi were cellular and one was melanocytic. Treatment included a two stage reconstruction in three cases and a single stage procedure in one case. The lower eyelid was usually treated first, and upper eyelid full thickness grafts were mostly used. Lid shortening was common, particularly in the cellular naevi. The results were aesthetically and functionally good. No major complications were observed.
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ABSTRACT: A collection of nevomelanocytes in the epidermis, dermis or both areas is known as melanocytic nevus. Common acquired melanocytic nevi form the most common type of melanocytic nevi, which develop after birth, slowly enlarge, stabilize and persist or regress later in life. Aside from common acquired melanocytic nevi, there are several forms of less well-known melanocytic nevi, such as halo, Meyerson's, ancient, speckled lentiginous, Spitz, dysplastic and cockade nevi. Congenital nevi, blue nevi and dermal melanocytoses are rather uncommon variants of melanocytic nevi. In this article, these less well-known types of melanocytic nevi are reviewed.
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ABSTRACT: Giant congenital melanocytic nevus (GCMN) is an infrequently occurring congenital malformation. GCMN generally occurs in isolation but rare familial occurrence points to a genetic background. We present two cases of familial GCMN: one with two affected siblings and another with two affected double second cousins. Familial occurrence of GCMN reported in literature is reviewed and an overview of the embryology and proliferation given, illustrating the plethora of factors that might lead to GCMN formation. The pattern of inheritance is likely not Mendelian and discordance in identical twins and the segmental distribution of lesions suggest a post-zygotic mutation. A polygenic paradominant inheritance best explains the clinically observed transmission pattern. Candidate genes include those influencing neural crest development and melanocyte proliferation.
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