Athar M, Back JH, Tang X et al.Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol 224:274-283

Department of Dermatology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street VC15-204, New York, NY 10032, USA.
Toxicology and Applied Pharmacology (Impact Factor: 3.71). 12/2007; 224(3):274-83. DOI: 10.1016/j.taap.2006.12.025
Source: PubMed


The search for novel and effective cancer chemopreventive agents has led to the identification of various naturally occurring compounds one of which is resveratrol (trans-3,4',5-trihydroxystilbene), a phytoalexin derived from the skin of grapes and other fruits. Resveratrol is known to have potent anti-inflammatory and antioxidant effects and to inhibit platelet aggregation and the growth of a variety of cancer cells. Its potential chemopreventive and chemotherapeutic activities have been demonstrated in all three stages of carcinogenesis (initiation, promotion, and progression), in both chemically and UVB-induced skin carcinogenesis in mice, as well as in various murine models of human cancers. Evidence from numerous in vitro and in vivo studies has confirmed its ability to modulate various targets and signaling pathways. This review discusses the current preclinical and mechanistic data available and assesses resveratrol's anticancer effects to support its potential as an anticancer agent in human populations.

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Available from: Mohammad Athar, Feb 11, 2015
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    • "Interestingly some natural products have shown synergistic effects with chemotherapeutic drugs and are also effective against multi drug resistance cancers (Athar et al., 2007; Gu et al., 2013; Liu and Chen, 2013). Boswellia ovalifoliolata (BO), an indigenous plant is mainly found in the areas of nilgiri hills of southern India. "
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    ABSTRACT: The present study was aimed at evaluation the apoptogenic potential of ethanolic extract of leaves from Boswellia ovalifoliolata (BL EthOH) and to explore the mechanism responsible for those activities implicated in Triple Negative Breast Cancer (TNBC) cells. BL EthOH was cytotoxic against TNBC cells like MDA-MB-231 and MDA-MB-453 with IC50 concentrations 67.48 ± 5.45 and 70.03 ± 4.76 μg/ml respectively. Apoptotic studies showed that BL EthOH was able to induce apoptosis and western blot studies demonstrated that BL EthOH significantly decreased the Phospho-NF-κB (ser536), PCNA, anti-apoptotic protein Bcl-2 expression and increased the expression of pro-apoptotic protein Bax, in MDA-MB-231 and MDA-MB-453 cell lines when compared with untreated cells. Besides, BL EthOH has synergistic chemosensitizing effects on TNBC cells and increased the cytotoxicity of doxorubicin and cisplatin.
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    • "Therefore, it will be also interesting to examine whether REV and its oligomers have the potential to be useful as therapeutic agents for the treatment of other types of IR-induced tissue damage. Interestingly, it has been reported that a variety of cancer cells, including gastric, colorectal, lung, breast, prostate, esophageal, and thyroid carcinomas, can be inhibited by REV and its oligomers [25, 26]. Therefore, REV and its oligomers have the potential to increase the therapeutic efficacy of radiotherapy, not only by reducing tissue injury but also by inhibiting tumor growth. "
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    ABSTRACT: Ionizing radiation (IR) is known not only to cause acute bone marrow (BM) suppression but also to lead to long-term residual hematopoietic injury. These effects have been attributed to IR inducing the generation of reactive oxygen species (ROS) in hematopoietic cells. In this study, we examined if isorhapontigenin and heyneanol-A, two analogues of resveratrol, could mitigate IR-induced BM suppression. The results of cell viability assays, clonogenic assays, and competitive repopulation assays revealed that treatment with these compounds could protect mice BM mononuclear cells (BMMNC), hematopoietic progenitor cells, and hematopoietic stem cells from IR-induced BM suppression. Moreover, the expression of genes related to the endogenous cellular antioxidant system in hematopoietic cells was analyzed. The expression and activity of SOD2 and GPX1 were found to be decreased in irradiated BMMNC, and the application of the resveratrol analogues could ameliorate this damage. Our results suggest that in comparison with resveratrol and isorhapontigenin, treatment with heyneanol-A can protect hematopoietic cells from IR-induced damage to a greater degree; the protective effects of these compounds are probably the result of their antioxidant properties.
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    • "Animal studies reporting beneficial effects of resveratrol in cancer have recently been published (Athar et al., 2007). "
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    ABSTRACT: The pleiotropic effects of resveratrol include anti-inflammatory, antioxidant and anti-cancer activities, and thus unique possibilities exist to explore mechanistic pathways of chemoprevention. The aim of this study was to investigate the role of miRNA alterations induced by resveratrol in the context of chemopreventive mechanisms against dextran sodium sulphate (DSS) induced colitis-associated tumorigenesis in the ApcMin/+ mouse. To that end, ApcMin/+ mice were exposed to 2% DSS to enhance intestinal inflammation and polyp development. Concurrently, mice received either vehicle or resveratrol treatment via oral gavage for five weeks. Interestingly, treatment of DSS-exposed mice with resveratrol resulted in decreased number and size of polyps, fewer histological signs of cell damage and decreased proliferating epithelial cells in intestinal mucosa compared to vehicle. Resveratrol treatment dramatically reversed the effects of DSS on the numbers of specific inflammatory CD4+ T cells, CD8+ T cells, B cells, natural killer T (NKT) cells and myeloid derived suppressor cells (MDSCs) in mesenteric lymph nodes. Resveratrol treatment also decreased IL-6 and TNF-α protein levels and reduced IL-6 and COX-2 mRNA expression. Microarray analysis revealed 104 microRNAs exhibiting greater than 1.5-fold differences in expression in the intestinal tissue of resveratrol treated mice. Among them, two microRNAs with anti-inflammatory properties, miRNA-101b and miRNA-455, were validated to be upregulated with resveratrol treatment by RT-PCR. Pathway analysis revealed that numerous differentially regulated miRNAs targeted mRNAs associated with inflammatory processes with known roles in intestinal tumorigenesis. These results suggest that resveratrol mediates anti-inflammatory properties and suppresses intestinal tumorigenesis through miRNA modulation.
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