Article

Evaluation of hypothalamic-specific autoimmunity in patients with narcolepsy

Neurology Service, Hospital Clinic de Barcelona and Institut d'Investigació Biomédica August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Sleep (Impact Factor: 4.59). 02/2007; 30(1):27-8.
Source: PubMed

ABSTRACT

An autoimmune-mediated mechanism is considered the most probable etiology for narcolepsy. However, this hypothesis remains unproven. Since narcolepsy is characterized by dysfunction of the hypothalamic hypocretinergic (orexinergic) system, we evaluated the presence of hypothalamic-specific antibodies in sera and CSF of 25 hypocretin-deficient and 6 non-deficient narcoleptic patients by immunohistochemistry and analyzing a screening of a rat cDNA expression hypothalamic library. There was no hypothalamic-specific reactivity in serum or CSF by inmmunohistochemistry. The screening of the hypothalmic library detected some reactive clones but not a common reactivity. Our study did not find any evidence of hypothalamic-specific autoimmunity in narcolepsy.

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Available from: JE Martínez-Rodríguez, Apr 10, 2014
    • "In search for evidence for an autoimmune attack, several research groups (including our own) attempted to find autoantibodies against hypocretin neurons. Unfortunately, up to now none of them was convincingly successful (Overeem et al., 2006; Knudsen et al., 2007; Martínez-Rodríguez et al., 2007; Dauvilliers et al., 2013). However, in 2010, three independent groups reported elevated levels of antibodies against a protein that is produced in hypocretin neurons, Tribbles homolog 2 (TRB2) (Cvetkovic-Lopes et al., 2010; Kawashima et al., 2010; Toyoda et al., 2010). "
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