Article

Resting State Cortical Connectivity Reflected in EEG Coherence in Individuals With Autism

University of Washington Autism Center, Seattle, Washington 98195, USA.
Biological Psychiatry (Impact Factor: 10.26). 09/2007; 62(3):270-3. DOI: 10.1016/j.biopsych.2006.11.012
Source: PubMed

ABSTRACT

Theoretical conceptions of autism spectrum disorder (ASD) and experimental studies of cerebral blood flow suggest abnormalities in connections among distributed neural systems in ASD.
Functional connectivity was assessed with electroencephalographic coherence between pairs of electrodes in a high-density electrode array in narrow frequency bands among 18 adults with ASD and 18 control adults in an eyes closed resting state.
In the theta (3-6 Hz) frequency range, locally elevated coherence was evident for the ASD group, especially within left hemisphere frontal and temporal regions. In the lower alpha range (8-10 Hz), globally reduced coherence was evident for the ASD group within frontal regions and between frontal and all other scalp regions. The ASD group exhibited significantly greater relative power between 3 and 6 Hz and 13-17 Hz and significantly less relative power between 9 and 10 Hz.
Robust patterns of over- and under-connectivity are apparent at distinct spatial and temporal scales in ASD subjects in the eyes closed resting state.

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    • "To date, prior studies have only examined resting state EEG coherence in individuals with ASD (Murias et al. 2007; Coben et al. 2008; Mathewson et al 2012). To our knowledge, this is the first study to examine EEG coherence during joint attention in adolescents with ASD. "
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    ABSTRACT: Although prior studies have demonstrated reduced resting state EEG coherence in adults with autism spectrum disorder (ASD), no studies have explored the nature of EEG coherence during joint attention. We examined the EEG coherence of the joint attention network in adolescents with and without ASD during congruent and incongruent joint attention perception and an eyes-open resting condition. Across conditions, adolescents with ASD showed reduced right hemisphere temporal-central alpha coherence compared to typically developing adolescents. Greater right temporal-central alpha coherence during joint attention was positively associated with social cognitive performance in typical development but not in ASD. These results suggest that, in addition to a resting state, EEG coherence during joint attention perception is reduced in ASD.
    Full-text · Article · Dec 2015 · Journal of Autism and Developmental Disorders
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    • "Similar to the MRI studies, there have been mixed results with some children with ASD demonstrating reduced coherences (Khan et al., 2013; Coben et al., 2008), while others have shown increases in coherences (Murias et al., 2007; Orekhova et al., 2014; Dominguez et al., 2013) or mixed patterns (Barttfeld et al., 2011; Leveille et al., 2010; Duffy and Als, 2012). While it is not known why there are discrepancies in both the MRI and electrophysiology studies, the great variability in cohorts studied, age of subjects, state examined, patient number, and approach to data analysis likely all contribute to the lack of consensus. "
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    ABSTRACT: Background: While there is increasing evidence of altered brain connectivity in autism, the degree and direction of these alterations in connectivity and their uniqueness to autism has not been established. The aim of the present study was to compare connectivity in children with autism to that of typically developing controls and children with developmental delay without autism. Methods: We assessed EEG spectral power, coherence, phase lag, Pearson and partial correlations, and epileptiform activity during the awake, slow wave sleep, and REM sleep states in 137 children aged 2 to 6. years with autism (n = 87), developmental delay without autism (n = 21), or typical development (n = 29). Findings: We found that brain connectivity, as measured by coherence, phase lag, and Pearson and partial correlations distinguished children with autism from both neurotypical and developmentally delayed children. In general, children with autism had increased coherence which was most prominent during slow wave sleep. Interpretation: Functional connectivity is distinctly different in children with autism compared to samples with typical development and developmental delay without autism. Differences in connectivity in autism are state and region related. In this study, children with autism were characterized by a dynamically evolving pattern of altered connectivity.
    Full-text · Article · Nov 2015 · EBioMedicine
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    • "Now, more studies pay more attention to Autism Spectrum Disorders (ASD) (Matsuura et al. 2008; Mirman et al. 2012) and Attention Deficit Hyperactivity Disorder (ADHD) (Duch and Dobosz 2011) patients. Previous studies showed that ASD persons had weak functional connections between the frontal lobe and the rest of the cortex (Murias et al. 2007), and a different brain structure in the prefrontal, striatal, cerebellar and thalamic circuits was found in ADHD individuals compared to controls (Krain and Castellanos 2006). Gamma-band oscillatory synchronization plays a key role in brain network integration and attention selection (Engel et al. 2001; Jensen et al. 2007). "

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