Article

A Critical Review of Complementary Therapies for Cancer-Related Fatigue

Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
Integrative Cancer Therapies (Impact Factor: 2.36). 04/2007; 6(1):8-13. DOI: 10.1177/1534735406298143
Source: PubMed

ABSTRACT

To review the available literature on the use of complementary and alternative medicine (CAM) treatments for cancer-related fatigue with an aim to develop directions for future research.
PubMed, EMBASE, CINAHL, PsycINFO, and SPORTDiscus were searched for relevant studies. Original clinical trials reporting on the use of CAM treatments for cancer-related fatigue were abstracted and critically reviewed.
CAM interventions tested for cancer-related fatigue include acupuncture, aromatherapy, adenosine triphosphate infusions, energy conservation and activity management, healing touch, hypnosis, lectin-standardized mistletoe extract, levocarnitine, massage, mindfulness-based stress reduction, polarity therapy, relaxation, sleep promotion, support group, and Tibetan yoga. Several of these interventions seem promising in initial studies.
Currently, insufficient data exist to recommend any specific CAM modality for cancer-related fatigue. Therefore, potentially effective CAM interventions ready for further study in large, randomized clinical trials (eg, acupuncture, massage, levocarnitine, and the use of mistletoe) should be pursued. Other interventions should be tested in well-designed feasibility and phase II trials.

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    • "In developing countries, more than 5 billion people live in extreme poverty and a large number among them are suffering and trying to get safe water and basic medicines (WHO, 1995). In these peculiar environments, the population has no other alternative than to rely on traditional medical practitioners and medicinal plants for primary health care (WHO, 1995; Sood et al., 2007) and more than 80% of the rural population depends on plants (Okoro et al., 2010). Today, there is no doubt that complimentary medicines have wide acceptability and are attractting attention from scientific community world-wide (Newal et al., 1986). "
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    ABSTRACT: Crude ethanolic extract of Avicennia marina leaves was tested against seven allergenic fungi viz., Alternaria alternata, Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Cladosporium herbarum, Penicillium notatum and Saccharomyces cerevisiae using five different solvents: dimethyl sulphoxide (DMSO), distilled water (DW), chloroform, ethanol and acetone at 2000, 4000 and 6000 ppm doses. Dose dependent tendency in the increase or decrease in the growth of fungi was observed. Two synthetic drugs miconazole and amphotericin-B were used as positive control.
    Full-text · Article · Oct 2011 · AFRICAN JOURNAL OF BIOTECHNOLOGY
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    • "In developing countries, more than 5 billion people live in extreme poverty and a large number among them are suffering and trying to get safe water and basic medicines (WHO, 1995). In these peculiar environments, the population has no other alternative than to rely on traditional medical practitioners and medicinal plants for primary health care (WHO, 1995; Sood et al., 2007) and more than 80% of the rural population depends on plants (Okoro et al., 2010). Today, there is no doubt that complimentary medicines have wide acceptability and are attractting attention from scientific community world-wide (Newal et al., 1986). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Crude ethanolic extract of Avicennia marina leaves was tested against seven allergenic fungi viz., Alternaria alternata, Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Cladosporium herbarum, Penicillium notatum and Saccharomyces cerevisiae using five different solvents: dimethyl sulphoxide (DMSO), distilled water (DW), chloroform, ethanol and acetone at 2000, 4000 and 6000 ppm doses. Dose dependent tendency in the increase or decrease in the growth of fungi was observed. Two synthetic drugs miconazole and amphotericin-B were used as positive control. Miconazole was 100% effective against A. alternata, C. herbatum, P. notatum and S. cerevisiae with the concentrations of 95.00 ± 1.62, 78.00 ± 4.99, 100.00 ± 0.69 and 110.00 ± 2.33 (µg/ml of SDA medium), respectively. Amphotericin-B completely controlled the growth of A. flavus, A. fumigatus and A. niger in the concentration of 24.00 ± 17.00, 30.00 ± 15.66 and 18.00 ± 18.34 (µg/ml of SDA medium), respectively. Distilled water and DMSO were considered to be the most effective solvents preventing 83.00 ± 4.73% growth of A. niger, 80.33 ± 5.60% A. flavus, 78.58 ± 3.18% A. alternata, 72.91 ± 7.96% P. notatum, 65.25 ± 3.55% C. herbarum, 63.25 ± 4.52% A. fumigatus and 48.5 ± 7.89% S. cerevisiae. Statistically, the results were compared with negative control and found to be highly significant (p<0.01).
    Full-text · Article · Oct 2011
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    • "Fatigue is undertreated [5, 6], prevents a “normal” life [9], and could have a greater impact on the quality of life than pain or depression, which are symptoms also observed frequently in cancer patients [5]. Excellent reviews addressing fatigue in cancer patients and its associated problems have been published recently [10–12]. "
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    ABSTRACT: Fatigue is a symptom with a relevant impact on the daily lives of cancer patients and is gaining importance as an outcome measure. The Perform Questionnaire (PQ) is a new scale originally developed among Spanish-speaking patients for the assessment of perception and beliefs about fatigue in cancer patients. An observational longitudinal multicenter study was carried out on cancer patients with fatigue. Fatigue-specific measures (FACT-F), generic health-related quality-of-life measures (NHP), and PQ were gathered at baseline and 3 months later. Feasibility, reliability (internal consistency and test-retest), validity, sensitivity to change, and minimally important differences were analysed. Four hundred thirty-seven patients were included in the study: 60.5% were women, the mean age was 59.1 years, the mean time from diagnosis was 2.2 years, 33.6% of patients had breast cancer, and 29.1% had anaemia (haemoglobin (Hb) <11 g/dL). Low levels of missing items and ceiling/floor effects (<10%) were found. The overall Cronbach's alpha and intraclass correlation coefficient were 0.94 and 0.83, respectively. The PQ score was associated with fatigue intensity, the need for a caregiver, and the Hb level. Its association was stronger with the FACT-F than with non-specific health measures (NHP). The PQ showed good sensitivity to change for improved and worsening health status. A minimally important difference of 3.5 was estimated in patients whose Hb level had improved by at least 1 g/dL. The PQ measured the attitudes and beliefs about fatigue among cancer patients in clinical practice and showed good psychometric properties among Spanish-speaking patients.
    Full-text · Article · May 2011 · Supportive Care in Cancer
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