Flow cytometric analysis of CD4+ T cell receptor zeta chain deficiency in patients with systemic lupus erythematosus.

Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, Poland.
Advances in Medical Sciences (Impact Factor: 1.11). 02/2006; 51:181-3.
Source: PubMed

ABSTRACT

It has been reported that a dysfunction of T lymphocytes can be responsible for alteration in immune system in patients with systemic lupus erythematosus (SLE).
Using flow cytometric analysis, we determined the abnormalities of T cell receptor zeta (TCR zeta) chain contents in CD4+ T cells of SLE patients.
We observed a decrease in mean fluorescence intensity of TCR zeta in CD4+ T cells of patients with SLE. The multiple analysis did not show a correlation between gender, age, disease specific manifestation, treatment, duration and TCR zeta mean fluorescence intensity in CD4+ T cells.
High prevalence of TCR zeta chain deficiency in CD4+ T cells confirms the significance of this signaling molecule in SLE pathogenesis.

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