Article

Two years follow-up study of gold beads in dogs with hip-joint arthritis

Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway.
Acta Veterinaria Scandinavica (Impact Factor: 1.38). 02/2007; 49(1):9. DOI: 10.1186/1751-0147-49-9
Source: PubMed

ABSTRACT

Seventy-eight dogs with pain from hip dysplasia participated in a six-month placebo-controlled, double-blinded clinical trial of gold bead implantation. In the present, non-blinded study, 73 of these dogs were followed for an additional 18 months to evaluate the long-term pain-relieving effect of gold bead implantation. The recently-published results of the six month period revealed that 30 of the 36 dogs (83%) in the gold implantation group showed significant improvement (p = 0.02), included improved mobility and reduction in the signs of pain, compared to the placebo group (60% improvement).
In the long-term two-year follow-up study, 66 of the 73 dogs had gold implantation and seven dogs continued as a control group. The 32 dogs in the original placebo group had gold beads implanted and were followed for a further 18 months. A certified veterinary acupuncturist used the same procedure to insert the gold beads as in the blinded study, and the owners completed the same type of detailed questionnaires. As in the blinded study, one investigator was responsible for all the assessments of each dog. The present study revealed that the pain-relieving effect of gold bead implantation observed in the blinded study continued throughout the two-year follow-up period.

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    • "The anti-inflammatory activity of colloidal gold can be greatly increased by using the liposomes to target the inflamed joints, showing also the beneficial effect of reduced cartilage destruction [177]. Also the implantation of gold beads near arthritic hip joints has been found to relieve pain in dogs [178]. The latest gold rush is likely to revolutionize the field of biosensing and chemical sensing, by allowing to develop new technologies that can help identifying chemical or biological strains with high accuracy, by using highly environmentally sensitive nature of plasmon resonance as well as other optical effects (such as surface-enhanced Raman or fluorescence) associated with gold and other noble metal particles [14] [15]. "
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    ABSTRACT: The different methods for preparing gold nanoparticles will be referred, namely the traditional deposition-precipitation and co-precipitation techniques, variations of impregnation, reductive deposition, vapour-phase methods, ion exchange and colloidal gold. Also a brief history of the use of gold in medicine throughout the ages will be told. More recent uses of gold in cancer treatment and (bio)medical applications, to target tumors and provide detection, drug carriers, gene silencing, radiotherapy, etc, will also be referred.
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    • "It is known that acupuncture is practical, and apparently safe with minimal side effects when used for pain control (Cassu et al. 2008). Furthermore, this technique is effective for treating chronic pain (Jaeger et al. 2007; Joaquim et al. 2010) and comparable to NSAIDs and opioids for treating acute pain in dogs and cats (Cassu et al. 2008; Gakiya et al. 2011; Sousa et al. 2012). "
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    ABSTRACT: To correlate the demographic data of Brazilian veterinarians with their use of, attitudes towards, knowledge of and preference for continuing education regarding use of analgesics in small animal practice. Prospective survey. The questionnaire was composed of sections pertaining to demographics, personal data, use of analgesics in general and specific procedures, analgesia used, and attitudes towards the assessment and relief of pain. The descriptive statistics with frequency analysis was performed using sas for Windows 9.1.3. Chi-square for simple comparisons test was used. Questionnaires were obtained from 1298 small animal veterinarians. Women and younger graduates attributed higher pain scores than men and older graduates but the frequency and duration of analgesic treatment did not differ between genders. The most commonly used opioids were tramadol (79%) and morphine (51%). NSAIDs of choice were meloxicam (81%) and ketoprofen (70%). Cats received lower pain scores for laparotomy, orchiectomy and dental procedures than dogs. Practical experience (64%) and national (47%) and regional meetings (43%) were the main sources of information for identifying and treating pain in small animals. Although the number of Brazilian veterinarians believed that their knowledge in the area was lower than in other countries, the focus in pain management was similar or higher than in other countries, showing a good attitude in pain relief in animals.
    Full-text · Article · Jan 2014 · Veterinary Anaesthesia and Analgesia
    • "The anti-inflammatory activity of colloidal gold can be greatly increased by using the liposomes to target the inflamed joints, showing also the beneficial effect of reduced cartilage destruction [177]. Also the implantation of gold beads near arthritic hip joints has been found to relieve pain in dogs [178]. The latest gold rush is likely to revolutionize the field of biosensing and chemical sensing, by allowing to develop new technologies that can help identifying chemical or biological strains with high accuracy, by using highly environmentally sensitive nature of plasmon resonance as well as other optical effects (such as surface-enhanced Raman or fluorescence) associated with gold and other noble metal particles [14] [15]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: The different methods for preparing gold nanoparticles will be referred, namely the traditional deposition-precipitation and co-precipitation techniques, variations of impregnation, reductive deposition, vapour-phase methods, ion exchange and colloidal gold. Also a brief history of the use of gold in medicine throughout the ages will be told. More recent uses of gold in cancer treatment and (bio)medical applications, to target tumors and provide detection, drug carriers, gene silencing, radiotherapy, etc, will also be referred.
    No preview · Article · Jan 2014
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