Sleep-disordered breathing and effects on ocular health

University of Waterloo, School of Optometry, Waterloo, Ont., Canada.
Canadian Journal of Ophthalmology (Impact Factor: 1.33). 05/2007; 42(2):238-43. DOI: 10.1139/I07-029
Source: PubMed


Sleep-disordered breathing may make the eye vulnerable due to the direct effect of hypoxia or it can involve pathways that lead to impaired autoregulation of optic nerve perfusion. In this review, we discuss our present understanding of the interactions that occur between sleep-disordered breathing and the eye, with particular attention to discussing possible links with glaucoma, nonarteritic anterior ischemic optic neuropathy, visual field defects, papilledema, and floppy eyelid syndrome. The importance of understanding these relationships is the positive benefits to ocular health that can derive when sleep-disordered breathing is diagnosed and treated.

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Available from: Colin M Shapiro, Jul 30, 2015
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    • "The pathophysiologic mechanism of NAION in OSAS patients is still unclear. However, direct damage of the optic nerve due to OSAS-induced hypoxia, altered vascular autoregulation and vascular compression may contribute to the development of this condition [14, 15, 17, 18]. "
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    ABSTRACT: Purpose To describe a case of bilateral and simultaneous central retinal vein occlusion (RVO) in a young patient diagnosed with obstructive sleep apnea syndrome (OSAS). Case Report A 38-year-old man with morbid obesity and daytime sleepiness presented with a history of bilateral vision loss. His visual acuity (VA) was hand movements, and fundus examination (FE) revealed bilateral central RVO. General medical examination revealed untreated hypertension and type II respiratory failure. Laboratory tests for thrombophilia showed increased hematocrit (59%) and high levels of fibrinogen and C-reactive protein. Other causes of congenital and acquired hypercoagulability were ruled out. Pathologic polysomnography led to the diagnosis of OSAS. The patient was treated with antihypertensive drugs and continuous positive air pressure. In addition, he received intravitreal ranibizumab. At 10 months after presentation, his VA was no light perception in the right eye and hand movements in the left eye. FE revealed bilateral retinal and optic nerve atrophy, and the occurrence of a nonarteritic anterior ischemic neuropathy in the right eye was considered.
    Full-text · Article · May 2014 · Case Reports in Ophthalmology
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    • "OSAS-related hypoxia, hypercapnia, and decreased oxygen saturation have been shown to increase the risk of systemic blood and pulmonary hypertension, arrhythmia, myocardial infarction, congestive heart failure and stroke [5] [6] [7] [8] [9]. There have been reports that OSAS is also associated with ophthalmic disorders, including glaucoma (and normal tension glaucoma ), visual field changes, optic disk swelling, non-arteritic anterior ischemic optic neuropathy, central serous choroidoretinopathy , and retinal vein occlusions [10] [11] [12] [13] [14] [15] [16] [17]. Previous studies of glaucoma and OSAS use various study designs, patient populations, methods, and AHI cut-offs in their analyses. "
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    ABSTRACT: Objective: To investigate the prevalence of glaucoma, visual field abnormalities, as well as changes in retinal nerve fiber layer in patients with obstructive sleep apnea syndrome (OSAS). Methods: In this cross-sectional study, 51 patients with OSAS were included. Based on apnea hypopnea index (AHI), there were 26, 6 and 19 cases of severe (AHI⩾30), moderate (15⩽AHI<30), and mild (5⩽AHI<15) OSAS, respectively. The control group was matched for age, sex and body mass index. Prevalence of glaucoma and ocular hypertension as well as the following values were assessed and compared between two groups: best-corrected visual acuity, intraocular pressure, central corneal thickness (CCT), cup:disk ratio, mean deviation (MD), pattern standard deviation, and retinal nerve fiber layer (RNFL) parameters using glaucoma diagnosis measurement (GDx). Results: Seven eyes (6.7%) had intraocular pressure (IOP)>21mmHg; of these, four eyes (3.9%) had glaucoma. No significant difference was detected in CCT between the two groups. IOP was significantly higher in the OSAS group before (p<0.001) and after (p<0.001) correcting for CCT. There was a significant difference between groups in MD and most GDx parameters including DISK (temporal-superior-nasal-inferior-temporal) average (p=0.002), superior average (p=0.05) and nerve fiber indicator (NFI) (p=0.03), where those in the patient group showed lower values. There was a significant positive correlation between AHI and both IOP and NFI. Conclusions: OSAS patients had a higher prevalence of glaucoma and ocular hypertension. OSAS patients also had higher IOP, worse visual field indices, and lower RNFL parameters compared with the control group.
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    No preview · Article · Feb 2009 · Drug Safety
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