Lung Function Growth in Children with Long-Term Exposure to Air Pollutants in Mexico City

Instituto Nacional de Salud Publica, 655 Avenida Universidad, Col. Santa Maria Ahuacatitlán, Cuernavaca, Morelos 62508, México.
American Journal of Respiratory and Critical Care Medicine (Impact Factor: 13). 09/2007; 176(4):377-84. DOI: 10.1164/rccm.200510-1678OC
Source: PubMed


Although short-term exposure to air pollution has been associated with acute, reversible lung function decrements, the impact of long-term exposure has not been well established.
To evaluate the association between long-term exposure to ozone (O(3)), particulate matter less than 10 mum in diameter (PM(10)), and nitrogen dioxide (NO(2)) and lung function growth in Mexico City schoolchildren.
A dynamic cohort of 3,170 children aged 8 years at baseline was followed from April 23, 1996, through May 19, 1999. The children attended 39 randomly selected elementary schools located near 10 air quality monitoring stations and were visited every 6 months. Statistical analyses were performed using general linear mixed models.
After adjusting for acute exposure and other potential confounding factors, deficits in FVC and FEV(1) growth over the 3-year follow-up period were significantly associated with exposure to O(3), PM(10), and NO(2). In multipollutant models, an interquartile range (IQR) increase in mean O(3) concentration (IQR, 11.3 ppb) was associated with an annual deficit in FEV(1) of 12 ml in girls and 4 ml in boys, an IQR range (IQR, 36.4 microg/m(3)) increase in PM(10) with an annual deficit in FEV(1) of 11 ml in girls and 15 ml in boys, and an IQR range (IQR, 12.0 ppb) increase in NO(2) with an annual deficit in FEV(1) of 30 ml in girls and 25 ml in boys.
We conclude that long-term exposure to O(3), PM(10), and NO(2) is associated with a deficit in FVC and FEV(1) growth among schoolchildren living in Mexico City.

Download full-text


Available from: Teresa Fortoul
    • "Health of School Children Exposed to Rail Yard–Generated Air Pollution:The ENRRICH Study al., 2002), while researchers in a study conducted in Mexico City found no clear gender differences (Rojas-Martinez et al., 2007). The inland region of Southern California may provide a unique opportunity for health research examining this issue, given the perennially poor air quality experienced by San Bernardino County' s residents, combined with the existence of several local major freight rail yards. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Studies about environmental burdens often explore overall community risk. Increasing evidence suggests, however, differential burdens by gender and age. The purpose of the authors’ research was to determine if gender-related difference exists among children in a region plagued with poor air quality and if increased exposure to pollutants from a major goods movement rail yard influences the relationship. Using a cross-sectional study design, the authors provided respiratory screening for children at two elementary schools. Compared to females, males were at significantly greater odds of exhibiting elevated fractional exhaled nitric oxide (FeNO) but less likely to exhibit reduced lung volume. Even in an area of overall poor air quality, the authors found that male children were a vulnerable subpopulation for greater elevated FeNO, while females were at increased risk for reduced lung capacity. Understanding differential burdens in vulnerable subpopulations is critical to providing timely and responsive strategies targeted towards health-based prevention and intervention activities.
    No preview · Article · Jan 2016 · Journal of environmental health
  • Source
    • "In a cohort study of nearly 5000 school age children from 13 California communities, in which proximity to a major road (defined as within 75 m) was associated with an increased risk for lifetime asthma[49], this risk decreased to background rates at 150–200 m from the major roads. It has also been observed that children residing in close proximity to major roads in Mexico City and in Ciudad Juarez, Mexico, had evidence of increased airway inflammation and reduced lung volumes[31,50]. Close proximity to major roadways—a commonly used indicator of exposure to primary traffic-related emissions—has also been associated with acute cardiovascular events. In a study of 691 survivors of myocardial infarction, recent exposure (within 1–2 h) to traffic was associated with a 2–3-fold increase in the OR for having acute myocardial infarction[51]. "

    Full-text · Article · Dec 2015 · Nutrients
  • Source
    • "There is a strong evidence that especially increased air pollution with particulate matter (PM 10 and PM 2.5 ), and ozone (O 3 ), precipitates respiratory symptoms [1] [2] [3] [4] [5], and consequently emergency room visits and hospital admissions due to these symptoms [6] [7] [8] [9] [10]. Among the most susceptible population subgroups are children [3] [7] [11] [12] [13] [14] [15] [16] [17]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Aiming at assessing the feasibility of linkage of existing health and environmental data in Slovenia in the case of the Koper Municipality in identifying the grounded need for public health action, the objective of the study was to assess the association between consultations on the primary health care level due to asthma and daily ozone concentrations. An ecological time-trend study with a single day as a unit of observation was performed in 2012. Periods from April 1 through October 31 were observed in 2010 and 2011. The study population was children, aged 0-12 years, who visited the Community Health Centre Koper for asthma. Logistic regression was used in analysis. The results showed statistically significant association between daily occurrence of at least one consultation for asthma and ozone daily maximum 8-hr average concentration 70 μg/m 3 or exceeded, lag 4 days (OR=4.77; p=0.042). There is an evidence of association between increased ozone levels and daily occurrence of any consultation for asthma in Koper Municipality. The study opened many challenges for future research. If they are resolved, evidence-based approach to public health activities in the field of environmental health in the region and in Slovenia would be strongly improved on this basis thereof.
    Full-text · Article · Dec 2014
Show more