Neurocognitive and neuroimaging correlates of pediatric traumatic brain injury: A diffusion tensor imaging (DTI) study

Hennepin County Medical Center, Minneapolis, Minnesota, United States
Archives of Clinical Neuropsychology (Impact Factor: 1.99). 07/2007; 22(5):555-68. DOI: 10.1016/j.acn.2007.03.004
Source: PubMed


This study examined the sensitivity of diffusion tensor imaging (DTI) to microstructural white matter (WM) damage in mild and moderate pediatric traumatic brain injury (TBI). Fourteen children with TBI and 14 controls ages 10-18 had DTI scans and neurocognitive evaluations at 6-12 months post-injury. Groups did not differ in intelligence, but children with TBI showed slower processing speed, working memory and executive deficits, and greater behavioral dysregulation. The TBI group had lower fractional anisotropy (FA) in three WM regions: inferior frontal, superior frontal, and supracallosal. There were no group differences in corpus callosum. FA in the frontal and supracallosal regions was correlated with executive functioning. Supracallosal FA was also correlated with motor speed. Behavior ratings showed correlations with supracallosal FA. Parent-reported executive deficits were inversely correlated with FA. Results suggest that DTI measures are sensitive to long-term WM changes and associated with cognitive functioning following pediatric TBI.

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Available from: Jeffrey R Wozniak, Mar 23, 2015
    • "Ecological assessment of flexibility using the BRIEF questionnaire supports these results, with at least half of the group performing in the clinical range, and overall elevated mean scores, rated by parents as well as teachers. This is consistent with case reports and group studies in the literature, reporting flexibility deficits following childhood focal or more diffuse frontal brain lesions (Power, Catroppa, Coleman, Ditchfield, & Anderson, 2007; Wozniak et al., 2007). Specific working memory deficits are also evident in our study, measured with the WMI of the Wechsler Scales. "
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    • "Over time, this damage to axons results in the development of gaps between fibres which were previously tightly packed. It is reported that this change facilitates water diffusion in the directions perpendicular to the axons, which in turn decreases FA observed in DAI [13, 18]. When comparing the right-side structures in our patient with those of age-matched controls, decreased FA values were observed in the cerebral peduncle, the posterior limb of the internal capsule, and the corona radiata. "
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