Article

Effects of personal particulate matter on peak expiratory flow rate of asthmatic children

Feng Chia University, 臺中市, Taiwan, Taiwan
Science of The Total Environment (Impact Factor: 4.1). 09/2007; 382(1):43-51. DOI: 10.1016/j.scitotenv.2007.04.016
Source: PubMed

ABSTRACT

Many researches have shown that the particulate matter (PM) of air pollution could affect the pulmonary functions, especially for susceptible groups such as asthmatic children, where PM might decrease the lung function to different extents. To assess the effects of PM on health, most studies use data from ambient air monitoring sites to represent personal exposure levels. However, the data gathered from these fixed sites might introduce certain statistical uncertainties. The objectives of this study are to evaluate the effects of various size ranges of PM on peak expiratory flow rate (PEFR) of asthmatic children, and to compare the model performance of using different PM measurements (personal exposures versus fixed-site monitoring) in evaluation. Thirty asthmatic children, aged 6 to 12 years, who live near the fixed monitoring site in Sin-Chung City, Taipei County, Taiwan, were recruited for the study. Personal exposures to PM(1), PM(2.5), and PM(10) were measured continuously using a portable particle monitor (GRIMM Mode 1.108, Germany). In addition, an activity diary and questionnaires were used to investigate possible confounding factors in their home environments. The peak expiratory flow rate of each participant was monitored daily in the morning and in the evening for two weeks. Results showed several trends, although not necessarily statistically significant, between personal PM exposures and PEFR measurements in asthmatic children. In general, notable findings tend to implicate that not only fine particles (PM(2.5)) but also coarse particles (PM(2.5-10)) are likely to contribute to the exacerbation of asthmatic conditions. Stronger lagged effect and cumulative effect of PM on the decrements in morning PEFR were also found in the study. Finally, results of linear mixed-effect model analysis suggested that personal PM data was more suitable for the assessment of change in children's PEFR than ambient monitoring data.

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    • "A limited ability to assess lagged effects over several days could be one explanation for the missing association as most other studies report lagged effects. However, a study from Taiwan in asthmatic children also found no significant associations for the PEF rate and different measures of air pollutants from personal measurements or a fixed monitoring site (Tang et al., 2007). Most studies on UFP particles and respiratory diseases are panel studies, and only one study on hospital admission for respiratory diseases has been carried out so far (Andersen et al., 2008). "
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